Evolution of pH-sensitive transcription termination in
Escherichia coli
during adaptation to repeated long-term starvation
Sarah B. Worthan,
Robert D. P. McCarthy,
Mildred Delaleau
et al.
Abstract:Fluctuating environments that consist of regular cycles of co-occurring stress are a common challenge faced by cellular populations. For a population to thrive in constantly changing conditions, an ability to coordinate a rapid cellular response is essential. Here, we identify a mutation conferring an arginine-to-histidine (Arg to His) substitution in the transcription terminator Rho. The
rho
R109H mutation frequently arose in
Escherichia coli
populations experim… Show more
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