Evolution Of Moderate Chronic Kidney Disease In The Elderly

Abstract

Recently, there is an increased interest in the detection of Chronic Kidney Disease (CKD) in the general population, especially . A classification of CKD, based on several stages of the estimated glomerular filtration rate (eGFR), has been established from almost 10 years. In our study we monitored eighthy patients older than 65 years, clinically and biochemically, during one year. A number of 80 clinically stable patients, with a median age of 74 years, recruited between october and december 2010, were followed up during one year. We separated them in two groups: Group 1: 40 patients with serum creatinine < = 1,2 mg/dl (range 0,7- 1,2) and with no proteinuria; and Group 2: 40 patients with serum creatinine > 1.2 mg/dl (range 1,2-3,5) and with proteinuria < 3,5 g/24 hours. We measured serum creatinine and eGFR at the time of recruitment and after one year of follow up using abreviated MDRD equation. Statistical comparisons were made using the general lineal model for repeated measures of the SPSS 11.0 program. The most frequent comorbidities were cardio-vascular(> 75%) and infections (25%). 13.75% of the patients died during the follow up, especially from group 2. Only 25% of group 2 patients needed erithropoietin (EPO) treatment. Estimated GFR and proteinuria remained relatively stable at the end of one year in patients from group 1, but survivors from group 2 registered a median decrease of 9 mL/min.