Evolution of guanylate binding protein genes shows a remarkable variability within bats (Chiroptera)
Ana Pinheiro,
J. Ricardo Borges,
João Vasco Côrte-Real
et al.
Abstract:BackgroundGBPs (guanylate binding proteins), an evolutionary ancient protein family, play a key role in the host’s innate immune response against bacterial, parasitic and viral infections. In Humans, seven GBP genes have been described (GBP1-7). Despite the interest these proteins have received over the last years, evolutionary studies have only been performed in primates, Tupaia and rodents. These have shown a pattern of gene gain and loss in each family, indicative of the birth-and-death evolution process.Re… Show more
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