Evolution of enzyme levels in metabolic pathways: A theoretical approach. Part 1

Coton, Charlotte; Talbot, G.; Louarn, Maud Le; Dillmann, Christine; Vienne, Dominique de

doi:10.1016/j.jtbi.2022.111015

Cited by 4 publications

(1 citation statement)

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“…Perspective: towards a general framework about metabolic pathway plasticity and evolution Apart from enzyme replacement and changes in enzyme order, there are several other additional possible mechanisms leading to metabolic pathway drift such as gene expression increase instead of gene duplication (Xu et al, 2017), variation in subcellular localization (Rıó Baŕtulos et al, 2018;Conart et al, 2023), changes in rate-limiting enzymes (Orlenko et al, 2016) or regulatory plasticity (Coton et al, 2022;Coton et al, 2023). However, before going into exploration of other possible mechanisms, it is necessary to fully understand how enzyme replacement and changes in enzyme order occur.…”

Section: The Laminariales Kelp/endophytic Ectocarpales Interaction In...mentioning

confidence: 99%

Empirical evidence for metabolic drift in plant and algal lipid biosynthesis pathways

Zonnequin,

Belcour,

Delage

et al. 2024

Front. Plant Sci.

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Metabolic pathway drift has been formulated as a general principle to help in the interpretation of comparative analyses between biosynthesis pathways. Indeed, such analyses often indicate substantial differences, even in widespread pathways that are sometimes believed to be conserved. Here, our purpose is to check how much this interpretation fits to empirical data gathered in the field of plant and algal biosynthesis pathways. After examining several examples representative of the diversity of lipid biosynthesis pathways, we explain why it is important to compare closely related species to gain a better understanding of this phenomenon. Furthermore, this comparative approach brings us to the question of how much biotic interactions are responsible for shaping this metabolic plasticity. We end up introducing some model systems that may be promising for further exploration of this question.

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Section: The Laminariales Kelp/endophytic Ectocarpales Interaction In...mentioning

confidence: 99%

Empirical evidence for metabolic drift in plant and algal lipid biosynthesis pathways

Zonnequin,

Belcour,

Delage

et al. 2024

Front. Plant Sci.

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show abstract

The genotype–phenotype relationship and evolutionary genetics in the light of the Metabolic Control Analysis

de Vienne,

Coton,

Dillmann

2023

Biosystems

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Evolution of enzyme levels in metabolic pathways: A theoretical approach. Part 2

Coton

Dillmann

Vienne

2023

Journal of Theoretical Biology

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Evolution of enzyme levels in metabolic pathways: A theoretical approach. Part 1

Cited by 4 publications

References 70 publications

Empirical evidence for metabolic drift in plant and algal lipid biosynthesis pathways

Empirical evidence for metabolic drift in plant and algal lipid biosynthesis pathways

The genotype–phenotype relationship and evolutionary genetics in the light of the Metabolic Control Analysis

Evolution of enzyme levels in metabolic pathways: A theoretical approach. Part 2

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