Evolution of Elective Intracranial Aneurysm Treatment

Lauzier, David C.; Cler, Samuel J.; Vellimana, Ananth K.; Osbun, Joshua W.; Chatterjee, Arindam; Derdeyn, Colin P.; Cross, DeWitte T.; Moran, Christopher J.; Kansagra, Akash P.

doi:10.1016/j.wneu.2022.08.133

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…Historically, cerebrovascular lesions were treated with open surgical resection or repair when intervention was necessary. 220 However, for bAVMs, IAs, and dAVFs, endovascular treatment comprises the majority of modern intervention, while CCMs continue to be treated surgically or with stereotactic radiosurgery. Coiling is a common treatment for IAs, and is sometimes used in dAVFs depending on morphological features.…”

Section: Therapeutic Targeting Of Macrophagesmentioning

confidence: 99%

Peripheral macrophages in the development and progression of structural cerebrovascular pathologies

Lauzier,

Srienc,

Vellimana

et al. 2023

J Cereb Blood Flow Metab

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The human cerebrovascular system is responsible for maintaining neural function through oxygenation, nutrient supply, filtration of toxins, and additional specialized tasks. While the cerebrovascular system has resilience imparted by elaborate redundant collateral circulation from supportive tertiary structures, it is not infallible, and is susceptible to developing structural vascular abnormalities. The causes of this class of structural cerebrovascular diseases can be broadly categorized as 1) intrinsic developmental diseases resulting from genetic or other underlying aberrations (arteriovenous malformations and cavernous malformations) or 2) extrinsic acquired diseases that cause compensatory mechanisms to drive vascular remodeling (aneurysms and arteriovenous fistulae). Cerebrovascular diseases of both types pose significant risks to patients, in some cases leading to death or disability. The drivers of such diseases are extensive, yet inflammation is intimately tied to all of their progressions. Central to this inflammatory hypothesis is the role of peripheral macrophages; targeting this critical cell type may lead to diagnostic and therapeutic advancement in this area. Here, we comprehensively review the role that peripheral macrophages play in cerebrovascular pathogenesis, provide a schema through which macrophage behavior can be understood in cerebrovascular pathologies, and describe emerging diagnostic and therapeutic avenues in this area.

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Section: Therapeutic Targeting Of Macrophagesmentioning

confidence: 99%

Peripheral macrophages in the development and progression of structural cerebrovascular pathologies

Lauzier,

Srienc,

Vellimana

et al. 2023

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

“… Representation of device selection for elective aneurysm treatments at our center over a 20-year period, which demonstrates a rapid adoption of flow diversion following its arrival and early signs of a similar trend with the WEB device. Figure adapted from prior work ( 6 ). …”

Section: Introductionmentioning

confidence: 99%