Evolution of DELLA function and signaling in land plants

Phokas, Alexandros; Coates, Juliet C.

doi:10.1111/ede.12365

Cited by 31 publications

(37 citation statements)

References 99 publications

(237 reference statements)

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“…auxin, JA and gibberellin, are mediated via SCF-26S proteasome-mediated degradation of negative regulators, such as Aux/IAA, JAZ and DELLA proteins, respectively (Shan et al, 2012). These repressors are pivotal in orchestrating complexity, specificity and sensitivity of signaling input and output of their corresponding pathways (Howe et al, 2018;Phokas and Coates, 2021;Salehin et al, 2015). The degradation of Aux/ IAA and DELLA proteins depends on both sequence variants and posttranslational modifications (Calder on Villalobos et al, 2012;Fu et al, 2002;Itoh et al, 2005;Sato and Yamamoto, 2008;Winkler et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Ectopic expression of OsJAZ6, which interacts with OsJAZ1, alters JA signaling and spikelet development in rice

et al. 2021

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Jasmonates (JAs) are key phytohormones that regulate plant responses and development. JASMONATE-ZIM DOMAIN (JAZ) proteins safeguard JA signaling by repressing JA-responsive gene expression in the absence of JA. However, the interaction and cooperative roles of JAZ repressors remain unclear during plant development. Here, we found that OsJAZ6 interacts with OsJAZ1 depending on a single amino acid in the so-called ZIM domain of OsJAZ6 in rice JA signaling transduction and JA-regulated rice spikelet development. In vivo protein distribution analysis revealed that the OsJAZ6 content is efficiently regulated during spikelet development, and biochemical and genetic evidence showed that OsJAZ6 is more sensitive to JAmediated degradation than OsJAZ1. Through over-and mis-expression experiments, we further showed that the protein stability and levels of OsJAZ6 orchestrate the output of JA signaling during rice spikelet development. A possible mechanism, which outlines how OsJAZ repressors interact and function synergistically in specifying JA signaling output through degradation titration, is also discussed.

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Section: Discussionmentioning

confidence: 99%

Ectopic expression of OsJAZ6, which interacts with OsJAZ1, alters JA signaling and spikelet development in rice

et al. 2021

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“…This is, in turn, an attractive explanation of the observed insensitivity of er/erl1/erl2 mutant to the application of exogenous gibberellin. DELLA proteins are involved in the sequestration of various transcription factors and chromatin remodeling complexes (Phokas and Coates, 2021). In this study, we extend the existing knowledge on DELLA functioning by providing evidence for the existence of the DELLA-SWI3B regulatory module and explaining why some GA-deficient mutant lines with impaired SWI/SNF chromatin remodeling complex do not accumulate DELLA proteins (Figure 5G).…”

Section: Discussionmentioning

confidence: 99%

A Non-Canonical Function of Arabidopsis ERECTA Proteins in Gibberellin Signaling

Sarnowska¹,

Kubala

Cwiek

et al. 2021

Preprint

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The Arabidopsis ERECTA family (ERf) of leucine-rich repeat receptor-like kinases (LRR-RLKs), comprising ERECTA (ER), ERECTA-LIKE 1 (ERL1) and ERECTA-LIKE 2 (ERL2), control epidermal patterning, inflorescence architecture, stomata development, and hormonal signaling. Here we show that the er/erl1/erl2 triple mutant exhibits impaired gibberellin (GA) biosynthesis and perception alongside broad transcriptional changes. ERf proteins interact in the nucleus, via kinase domains, with the SWI3B subunit of the SWI/SNF chromatin remodeling complex (CRCs). The er/erl1/erl2 triple mutant exhibits reduced SWI3B protein level and affected nucleosomal chromatin structure. The ER kinase phosphorylates SWI3B in vitro, and the inactivation of all ERf proteins leads to the decreased phosphorylation of SWI3B protein in vivo. Correlation between DELLA overaccumulation and SWI3B proteasomal degradation together with the physical interaction of SWI3B with DELLA proteins explain the lack of RGA accumulation in the GA- and SWI3B-deficient erf mutant plants. Co-localization of ER and SWI3B on GID1 (GIBBERELLIN INSENSITIVE DWARF 1) DELLA target gene promoter regions and abolished SWI3B binding to GID1 promoters in er/erl1/erl2 plants supports the conclusion that ERf-SWI/SNF CRC interaction is important for transcriptional control of GA receptors. Thus, the involvement of ERf proteins in transcriptional control of gene expression, and observed similar features for human HER2 (Epidermal Growth Family Receptor-member), indicate an exciting target for further studies of evolutionarily conserved non-canonical functions of eukaryotic membrane receptors.ONE SENTENCE SUMMARYERECTA leucine-rich receptor-like kinase and SWI3B subunit of SWI/SNF chromatin remodeling complex cooperate in direct transcriptional control of GID1 genes in Arabidopsis.

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“…The GAmediated plant responses are usually regulated by the SCF SLY1/GID2 complex, which is known to sense the GA signal and to recruit DELLA followed by ubiquitination and then degradation of DELLA, through the ubiquitin-26S proteasome, to activate the GA pathway [22,46]. Sequences of DELLA proteins from different plant species are relatively conserved, suggesting that their functions are similar [47,48]. DELLA proteins contain two conserved domains.…”

Section: Discussionmentioning

confidence: 99%

Geminivirus C4 proteins inhibit GA signaling via prevention of NbGAI degradation, to promote viral infection and symptom development in N. benthamiana

Guo

Lang

et al. 2021

Preprint

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Phytohormone gibberellin (GA) is an important plant signaling molecule that regulates plant growth and defense against abiotic and biotic stresses. To date, the molecular mechanism of the plant responses to viral infection mediated by GA is still undetermined. DELLA is a repressor of GA signaling and is recognized by the F-box protein, a component of the SCF SLY1/GID2 complex. The recognized DELLA is degraded by the ubiquitin-26S proteasome, leading to the activation of the GA signaling. Here, we report that ageratum leaf curl Sichuan virus (ALCScV)-infected N. benthamiana plants showed dwarfing symptom and abnormal flower development. The infection of ALCScV alters the expressions of GA pathway-related genes and decreases the content of endogenous GA significantly in N. benthamiana. Further, ALCScV-encoded C4 protein interacts with the DELLA protein NbGAI, and interferes with the interaction between NbGAI and NbGID2 to prevent the degradation of NbGAI, leading to the inhibition of the GA signaling pathway. Silencing of NbGAI or exogenous GA 3 treatment significantly reduces viral accumulation and disease symptoms in N. benthamiana plants. The same results were proved by the experiments with C4 protein encoded by tobacco curly shoot virus (TbCSV). Therefore, we propose a novel mechanism of geminivirus C4 proteins controling virus infection and disease symptom development through interfering GA signaling pathway.

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Evolution of DELLA function and signaling in land plants

Cited by 31 publications

References 99 publications

Ectopic expression of OsJAZ6, which interacts with OsJAZ1, alters JA signaling and spikelet development in rice

Ectopic expression of OsJAZ6, which interacts with OsJAZ1, alters JA signaling and spikelet development in rice

A Non-Canonical Function of Arabidopsis ERECTA Proteins in Gibberellin Signaling

Geminivirus C4 proteins inhibit GA signaling via prevention of NbGAI degradation, to promote viral infection and symptom development in N. benthamiana

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