• Irradiation-induced precipitates were observed after ion irradiation for both irradiation temperatures at 300 °C and 430 °C. • A probable mechanism for the distribution of vanadium-rich � precipitates is the heterogeneous nucleation. • The nucleation of precipitates is dominated by the Radiation Induced Segregation (RIS) phenomenon at 430 °C. • The influence of rising the irradiation temperature from 300 °C to 430 °C appears very modest for -type loops in Ti6-4.