Evolution of Bcl-2 Anthogenes (BAG) as the Regulators of Cell Death in Wild and Cultivated Oryza Species

Bansal, Ruchi; Kumawat, Surbhi; Dhiman, Pallavi; Sudhakaran, Sreeja; Rana, Nitika; Jaswal, Rajdeep; Singh, Akshay; Sonah, Humira; Sharma, Tilak Raj; Deshmukh, Rupesh

doi:10.1007/s00344-021-10552-7

Cited by 3 publications

(3 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, the involvement of tomato BAGs in fruit ripening, environmental stress, and dark-induced leaf senescence was reported ( Ding et al., 2020 ; He et al., 2021 ; Irfan et al., 2021 ; Ding et al., 2022 ; Jiang et al., 2022 ). The evolution of rice BAGs and their roles in cell death were studied ( Bansal et al., 2022 ). Here, we focus on the major advances of plant BAGs on their structures, biological functions, and molecular mechanisms of plant growth and stress response, in order to provide valuable information for further directions in this field and important cues for crop bioengineering.…”

Section: Introductionmentioning

confidence: 99%

“…The transformation of onion epidermal cells further proved that BAG6 might be localized in the nucleus ( Fu et al., 2019 ). In rice, the homologous protein OInBAG6 is located in the cytosol and nucleus ( Bansal et al., 2022 ). In tomato, SlBAG2 and SlBAG5b reside on the cell membrane and are located in the nucleus ( He et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Functional insights of plant bcl-2–associated ahanogene (BAG) proteins: Multi-taskers in diverse cellular signal transduction pathways

et al. 2023

View full text Add to dashboard Cite

Bcl-2-associated athanogene (BAG) gene family is a highly conserved molecular chaperone cofactor in evolution from yeast to humans and plants playing important roles in a variety of signal pathways. Plant BAG proteins have special structures, especially those containing CaM-binding IQ motifs which are unique to plants. While early studies focused more on the structure and physiological function of plant BAGs, recent studies have revealed many novel functional mechanisms involved in multiple cellular processes. How to achieve signal specificity has become an interesting topic of plant BAG research. In this review, we have provided a historic view of plant BAG research and summarized recent advances in the establishment of BAG as essential components in normal plant growth, environmental stress response, and plant immunity. Based on the relationship between BAG proteins and their newly interacting proteins, this review highlights the functional mechanisms of various cellular signals mediated by plant BAGs. Future work needs to focus on the post-translational modification of BAG proteins, and on understanding how specificity is achieved among BAG signaling pathways.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional insights of plant bcl-2–associated ahanogene (BAG) proteins: Multi-taskers in diverse cellular signal transduction pathways

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Multicopper oxidases were reported to be involved in the maintenance of P homeostasis in rice under P-deficiency stress (Cao et al, 2016 ). Similarly, Bcl-2-associated anthogenes (BAGs) are known to be involved in stress responses and modulate programmed cell death by controlling the rate of transcription both in plants and in animals (Doukhanina et al, 2006 ; Bansal et al, 2022 ). In addition, studies suggest that P homeostasis is also regulated through post-transcriptional mechanisms involving non-coding RNAs such as miR827, miR399, and IPS1 (Franco-Zorrilla et al, 2007 ; Chiou and Lin, 2011 ) as well as post-translational modifications (Park et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Pup1 QTL Regulates Gene Expression Through Epigenetic Modification of DNA Under Phosphate Starvation Stress in Rice

Kumar

Seem

Kumar³

et al. 2022

Front. Plant Sci.

View full text Add to dashboard Cite

Cytosine methylation, epigenetic DNA modification, is well known to regulate gene expression. Among the epigenetic modifications, 5-methylcytosine (5-mC) has been one of the extensively studied epigenetic changes responsible for regulating gene expression in animals and plants. Though a dramatic change in 5-mC content is observed at the genome level, the variation in gene expression is generally less than that it is expected. Only less is understood about the significance of 5-mC in gene regulation under P-starvation stress in plants. Using whole-genome bisulfite sequencing of a pair of rice [Pusa-44 and its near-isogenic line (NIL)-23 harboring Pup1 QTL] genotypes, we could decipher the role of Pup1 on DNA (de)methylation-mediated regulation of gene expression under P-starvation stress. We observed 13–15% of total cytosines to be methylated in the rice genome, which increased significantly under the stress. The number of differentially methylated regions (DMRs) for hypomethylation (6,068) was higher than those (5,279) for hypermethylated DMRs under the stress, particularly in root of NIL-23. Hypomethylation in CHH context caused upregulated expression of 489 genes in shoot and 382 genes in root of NIL-23 under the stress, wherein 387 genes in shoot and 240 genes in root were upregulated exclusively in NIL-23. Many of the genes for DNA methylation, a few for DNA demethylation, and RNA-directed DNA methylation were upregulated in root of NIL-23 under the stress. Methylation or demethylation of DNA in genic regions differentially affected gene expression. Correlation analysis for the distribution of DMRs and gene expression indicated the regulation of gene mainly through (de)methylation of promoter. Many of the P-responsive genes were hypomethylated or upregulated in roots of NIL-23 under the stress. Hypermethylation of gene body in CG, CHG, and CHH contexts caused up- or downregulated expression of transcription factors (TFs), P transporters, phosphoesterases, retrotransposon proteins, and other proteins. Our integrated transcriptome and methylome analyses revealed an important role of the Pup1 QTL in epigenetic regulation of the genes for transporters, TFs, phosphatases, carbohydrate metabolism, hormone-signaling, and chromatin architecture or epigenetic modifications in P-starvation tolerance. This provides insights into the molecular function of Pup1 in modulating gene expression through DNA (de)methylation, which might be useful in improving P-use efficiency or productivity of rice in P-deficient soil.

show abstract

Genome-Wide Identification of the Bcl-2 Associated Athanogene (BAG) Gene Family in Solanum lycopersicum and the Functional Role of SlBAG9 in Response to Osmotic Stress

Jiang

Sheng

et al. 2022

Antioxidants

View full text Add to dashboard Cite

The Bcl-2-associated athanogene (BAG) proteins are a family of multi-functional group of co-chaperones regulators, modulating diverse processes from plant growth and development to stress response. Here, 10 members of SlBAG gene family were identified based on the available tomato (Solanum lycopersicum) genomic information and named as SlBAG1-10 according to their chromosomal location. All SlBAG proteins harbor a characteristic BAG domain, categorized into two groups, and SlBAG4, SlBAG7, and SlBAG9 of group I contain a plant-specific isoleucine glutamine (IQ) calmodulin-binding motif located in the N terminus. The quantitative real-time PCR expression analysis revealed that these SlBAG genes had organ-specific expression patterns and most SlBAG genes were differentially expressed in multiple abiotic stresses including drought, salt, high temperature, cold, and cadmium stress as well as abscisic acid and H2O2. In addition, heterologous overexpression of SlBAG9 increased the sensitivity of Arabidopsis to drought, salt, and ABA during seed germination and seedling growth. The decreased tolerance may be due to the downregulation of stress-related genes expression and severe oxidative stress. The expression levels of some stress and ABA-related genes, such as ABI3, RD29A, DREB2A, and P5CS1, were significantly inhibited by SlBAG9 overexpression under osmotic stress. Meanwhile, the overexpression of SlBAG9 inhibited the expression of FSD1 and CAT1 under stress conditions and the decreased levels of superoxide dismutase and catalase enzyme activities were detected accompanying the trends in the expression of both genes, which resulted in H2O2 accumulation and lipid peroxidation. Taken together, these findings lay a foundation for the future study of the biological function of SlBAG genes in tomato.

show abstract

Evolution of Bcl-2 Anthogenes (BAG) as the Regulators of Cell Death in Wild and Cultivated Oryza Species

Cited by 3 publications

References 41 publications

Functional insights of plant bcl-2–associated ahanogene (BAG) proteins: Multi-taskers in diverse cellular signal transduction pathways

Functional insights of plant bcl-2–associated ahanogene (BAG) proteins: Multi-taskers in diverse cellular signal transduction pathways

Pup1 QTL Regulates Gene Expression Through Epigenetic Modification of DNA Under Phosphate Starvation Stress in Rice

Genome-Wide Identification of the Bcl-2 Associated Athanogene (BAG) Gene Family in Solanum lycopersicum and the Functional Role of SlBAG9 in Response to Osmotic Stress

Contact Info

Product

Resources

About