Evolution of arthropod visual systems: Development of the eyes and central visual pathways in the horseshoe crab <i>Limulus polyphemus</i> Linnaeus, 1758 (Chelicerata, Xiphosura)

Harzsch, Steffen; Vilpoux, Kathia; Blackburn, David C.; Platchetzki, David; Brown, Nadean L.; Melzer, Roland R.; Kempler, K; Battelle, Barbara‐Anne

doi:10.1002/dvdy.20960

Cited by 12 publications

(23 citation statements)

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“…At st 18, MyoIII mRNA expression first appears in rudimentary lateral and median photoreceptor cells (Figures 7A–B), but no expression was observed in the lateral sense organ. However, the anti-MyoIII antibody weakly labels the rudimentary lateral and median eyes, as well as the lateral sense organ beginning at st 18 (Figure 7D and Harzsch et al, 2006). Because the MyoIII antisera, but not our MyoIII riboprobe, labeled the lateral sense organ it suggests that another MyoIII-like protein is present in this sensory structure.…”

Section: Resultsmentioning

confidence: 99%

“…Lp MyoIII protein expression has been described for the embryonic lateral, median and ventral rudimentary photoreceptors, and larval and adult compound lateral eye ommatidial and medial ocellar photoreceptors (Battelle et al, 2001; Harzsch et al, 2006). The Lp MyoIII gene encodes a photoreceptor cell-specific, unconventional myosin that is under circadian regulation (Battelle et al, 1998).…”

Section: Resultsmentioning

confidence: 99%

“…Hartline, 1956; Barlow, 1969; Snodderly and Barlow, 1970; French, 1980; Sekiguchi et al, 1982; Barlow et al, 2001). More recently, molecular approaches have been applied to studies of Limulus eye development (Harzsch et al, 2006). During embryogenesis three types of rudimentary eyes (lateral, median and ventral) develop and innervate the brain (see Figure 1 of Harzsch et al, 2006 for detailed diagrams).…”

Section: Introductionmentioning

confidence: 99%

“…More recently, molecular approaches have been applied to studies of Limulus eye development (Harzsch et al, 2006). During embryogenesis three types of rudimentary eyes (lateral, median and ventral) develop and innervate the brain (see Figure 1 of Harzsch et al, 2006 for detailed diagrams). All are closely associated with pigmented cells termed guanophores, and these eyes seem to provide phototic input during embryonic and early larval life (French, 1980; Harzsch et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…During embryogenesis three types of rudimentary eyes (lateral, median and ventral) develop and innervate the brain (see Figure 1 of Harzsch et al, 2006 for detailed diagrams). All are closely associated with pigmented cells termed guanophores, and these eyes seem to provide phototic input during embryonic and early larval life (French, 1980; Harzsch et al, 2006). Subsequently, the lateral compound eye and median ocellar eyes develop during larval stages and provide major visual inputs in adult animals.…”

Section: Introductionmentioning

confidence: 99%

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Isolation and expression of Pax6 and atonal homologues in the American horseshoe crab, Limulus polyphemus

Blackburn

Conley

Plachetzki

et al. 2008

Developmental Dynamics

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Pax6 regulates eye development in many animals. In addition, Pax6 activates atonal transcription factors in both invertebrate and vertebrate eyes. Here, we investigate the roles of Pax6 and atonal during embryonic development of Limulus polyphemus rudimentary lateral, medial and ventral eyes, and the initiation of lateral ommatidial eye and medial ocelli formation. Limulus eye development is of particular interest because these animals hold a unique position in arthropod phylogeny and possess multiple eye types. Furthermore, the molecular underpinnings of eye development have yet to be investigated in chelicerates. We characterized a Limulus Pax6 gene, with multiple splice products and predicted protein isoforms, and one atonal homologue. Unexpectedly, neither gene is expressed in the developing eye types examined, although both genes are present in the lateral sense organ, a structure of unknown function.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Isolation and expression of Pax6 and atonal homologues in the American horseshoe crab, Limulus polyphemus

Blackburn

Conley

Plachetzki

et al. 2008

Developmental Dynamics

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Patients' preferences for decision making and the feeling of being understood in the medical encounter among patients with rheumatoid arthritis

Ishikawa¹,

Hashimoto²,

Yano³

2006

Arthritis & Rheumatism

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Objective. To examine how patients' preferences for decision making in the medical encounter affect the association between their participation style and the feeling of being understood by the physician. Methods. The study group comprised 115 patients with rheumatoid arthritis who were under continuous care by 8 rheumatologists at a university-affiliated rheumatology clinic in Tokyo, Japan. A questionnaire was distributed just after each encounter, in which patients' self-reported participation in communication during the visit, preference for decision making, and the feeling of being understood were measured. The feeling of being understood was regressed on the participation style and preference for decision making after controlling for demographic and functional variables.

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Coming into clear sight at last: Ancestral and derived events during chelicerate visual system development

Friedrich

2022

BioEssays

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Pioneering molecular work on chelicerate visual system development in the horseshoe crab Limulus polyphemus surprised with the possibility that this process may not depend on the deeply conserved retinal determination function of Pax6 transcription factors. Genomic, transcriptomic, and developmental studies in spiders now reveal that the arthropod Pax6 homologs eyeless and twin of eyeless act as ancestral determinants of the ocular head segment in chelicerates, which clarifies deep gene regulatory and structural homologies and recommends more unified terminologies in the comparison of arthropod visual systems. Following this phylotypic stage, chelicerate visual system development differs fundamentally from other arthropods during the compartmentalization of the ocular segment in that eye and optic neuropil primordia originate independently from each other. Comparative analyses of this phase identified further gene regulatory homologies but also major differences, most notably the possibly compensatory replacement of Pax6 by Pax2 in lateral eye specification. Also see the video

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Evolution of arthropod visual systems: Development of the eyes and central visual pathways in the horseshoe crab Limulus polyphemus Linnaeus, 1758 (Chelicerata, Xiphosura)

Abstract: Dorsal view of a larva of the horseshoe crab Limulus polyphemus (Chelicerata, Xiphosura) showing the paired lateral eyes and the median eyes. See Harzsch et al., Developmental Dynamics 235:2641–2655.

Cited by 12 publications

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Isolation and expression of Pax6 and atonal homologues in the American horseshoe crab, Limulus polyphemus

Isolation and expression of Pax6 and atonal homologues in the American horseshoe crab, Limulus polyphemus

Patients' preferences for decision making and the feeling of being understood in the medical encounter among patients with rheumatoid arthritis

Coming into clear sight at last: Ancestral and derived events during chelicerate visual system development

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