2017
DOI: 10.1016/j.neuron.2016.12.024
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Evolution of Acid-Sensing Olfactory Circuits in Drosophilids

Abstract: Animals adapt their behaviors to specific ecological niches, but the genetic and cellular basis of nervous system evolution is poorly understood. We have compared the olfactory circuits of the specialist Drosophila sechellia-which feeds exclusively on Morinda citrifolia fruit-with its generalist cousins D. melanogaster and D. simulans. We show that D. sechellia exhibits derived odor-evoked attraction and physiological sensitivity to the abundant Morinda volatile hexanoic acid and characterize how the responsib… Show more

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Cited by 186 publications
(337 citation statements)
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References 74 publications
(129 reference statements)
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“…Alternatively, an Adafruit 8 x 8 high-power single-wavelength LED matrix [20] can be attached for spatially selective optogenetic or visual stimulation [29]. For demonstration, a zebrafish larva (3 dpf ) expressing ChR2 in all neurons was mounted on top of a microscope slide, which was in turn held above the inverted objective using the micromanipulator (Fig 5A and 5C).…”
Section: Resultsmentioning
confidence: 99%
“…Alternatively, an Adafruit 8 x 8 high-power single-wavelength LED matrix [20] can be attached for spatially selective optogenetic or visual stimulation [29]. For demonstration, a zebrafish larva (3 dpf ) expressing ChR2 in all neurons was mounted on top of a microscope slide, which was in turn held above the inverted objective using the micromanipulator (Fig 5A and 5C).…”
Section: Resultsmentioning
confidence: 99%
“…Olfactory receptors are considered narrowly or broadly tuned based on analysis of ligands that may not be relevant at all for the fly (Bohbot and Pitts, 2015). Few works have linked olfactory ecology to structural and regulatory genetic changes in the chemoreceptor families (Prieto-Godino et al, 2017), but in upcoming years, new genome-editing technologies and the advancement of next-generation sequencing in insect species other than Drosophila will shed light on the function and evolution of both the OR and IR families (Arguello and Benton, 2017), and such work will have repercussions for controlling pests and diseases transmitted by insect vectors (van der Goes van Naters and Carlson, 2006; Crava et al, 2016; Benton, 2017). …”
Section: Discussion and Closing Remarksmentioning
confidence: 99%
“…Although X-ray crystallography 3D structures for IRs are not yet available, some protein homology modeling has been performed (Prieto-Godino et al, 2016, 2017). Still, the exact molecular mechanism of IR activation by different specific odorants remains to be shown, as for ORs.…”
Section: The Molecular Basis Of Chemosensation In Drosophila: Moleculmentioning
confidence: 99%
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“…Different drosophilids encounter vastly different olfactory environments to which they need to adapt. Although one can observe differences in the number of olfactory glomeruli and the range of olfactory receptors used (40, 42, 97), the circuits seem to remain unchanged (106). Similarly, in the visual system, the expression of different Rhodopsins in photoreceptors has changed across species (143), increasing or decreasing sensitivity for specific wavelengths without actually changing the circuit downstream of the photoreceptors.…”
Section: Evolution Of Neural Circuitsmentioning
confidence: 99%