Evolution and Molecular Characterization of Methicillin-Resistant Staphylococcus aureus Epidemic and Sporadic Clones in Cordoba, Argentina

Characterization of Baseline Methicillin-Resistant Staphylococcus aureus Isolates Recovered from Phase IV Clinical Trial for Linezolid

“…Previous reports have described the predominance of the Brazilian clone (ST239-SCCmec IIIA, renamed the South American clone) in hospitals in Brazil, Uruguay, Chile, and Argentina (27); however, recent studies have shown the replacement of this clone by the Cordobes/Chilean clone (ST5-SCCmec I), which has predominantly been isolated in Argentina, Chile, and Paraguay (20,26). In this study, MRSA strains from South American countries largely clustered within the Cordobes/Chilean clone, being detected in four countries and prevailing in three of them.…”

Molecular Characterization of Methicillin-Resistant Staphylococcus aureus Isolates Collected in Asunción, Paraguay

“…The Cordobes/Chilean clone belongs to CC5, as do the pediatric clone and the New York/Japan clone. These clones are also genetically related to the early United Kingdom EMRSA-3 strain, indicating that they share a common ancestor (13). This genetic background is also shared with methicillin-susceptible S. aureus (MSSA) strains isolated in Argentina (13,15), and Sola et al suggested that the Cordobes/Chilean clone possibly emerged from a local MSSA strain, which acquired SCCmec (13).…”

“…The Sentry Antimicrobial Surveillance Program conducted several studies during 1997 and 1998 in Latin America (Argentina, Brazil, Chile, Colombia, Mexico, Uruguay, and Venezuela) and reported MRSA prevalence rates of 21% in bloodstream infections, 31% in skin and soft-tissue infections, and 50% in cases of pneumonia (1,12). The MRSA clones spreading in South America belonged mainly to the Brazilian clone (in Argentina, Brazil, Chile, and Uruguay) between 1992 and 1998, to the pediatric clone (in Colombia) between 1996 and 1998 (11), and to the Cordobes/Chilean clone (in Chile and Argentina) between 1998 and 2002 (13,15 Of these MRSA, 34 isolates (one isolate per patient) were characterized by means of standard microbiological methods. Toxin gene content and the gene regulator (agr) allele group (groups 1 to 4) were determined by using multiplex PCR and primers described previously (7,8).…”

“…Our study was carried out in 2005 only, and we do not know if the Cordobes/Chilean clone has progressively replaced the pandemic clone in Paraguay, as observed in Argentina (13). The Cordobes/Chilean clone belongs to CC5, as do the pediatric clone and the New York/Japan clone.…”

Staphylococcus aureus adquiridos en la comunidad: caracterización clínica, fenotípica y genotípica de aislados en niños paraguayos

“…Este factor de virulencia ha sido ampliamente descrito en aislados resistentes a meticilina, pero su rol en infecciones causadas por SASM se ha estudiado de forma reciente en distintas latitudes 31,37,38 . Así, hay reportes de SASM portadores de luk-PV, tanto a nivel internacional como regional.…”