Evolution and Exploration of Azadirachta indica in Dentistry: An Update

Abstract

Despite great achievements globally in oral health of populations, dental caries and periodontal diseases are the most important oral health burdens particularly among underprivileged groups in developed and developing countries. Nonetheless, oral cancer is the sixth most common cancer reported globally with an annual incidence of over 300,000 cases, of which 62% arise in developing countries. Apart from the traditional therapeutic modalities available so far that are usually synthetic drugs, researchers are presently discovering unexplored horizons of herbs for curing these ailments. One such beneficial herb is Azadirachta indica (Neem) that has been widely accepted throughout the world for its innumerable medicinal properties. The limitless benefits of neem has been documented in Indian traditional medicinal books like 'Charak-Samhita' & 'Sushruta-Samhita'. Neem tree has been valued long back, since centuries by the Indian citizens for cleaning the teeth, skin diseases, consumption as a tonic & eradicating worms etc & many more. The present review discusses the in-vivo, in-vitro and animal studies utilizing the electronic

Azadirachta indica –Neem-A natural gift for prevention and treatment of chronic diseases- A review

“…(Alzohairy, 2016). Beside this other essential compounds found in the neem leaves are nimbanene, nimbandiol, nimbin, nimbolide, amino acid and nimbiol (Gupta et al, 2017). Phytochemical analysis of methanolic leaf extracts of Azadirachta indica has shown the presence of biological compounds like, Alkaloids, Flavonoids, Saponins, etc which are then compared to aqueous leaf extracts of the plant (Dash and Dixit, 2017).…”

“…It is also known in various names like holy tree, Indian lilac tree, Nim and Nimba. According to the Persian it is derived from three Latin words these are-Azad means "free"; dirakht means "tree"; i-Hind means (Gupta et al, 2017). Neem is one of the most significant multi-reason trees to the Indian subcontinent, but cultivated throughout the world mainly Southeast Asia, Australia, East and Sub-Saharan Africa, Fiji, Mauritius and many countries of central and South America (Kumar et al, 2019).…”

“…Azadirachtin is one of the neem plant's most prevalent chemicals, which having insecticidal properties as well as used as a bio-pesticide (Chaudhary et al, 2017;Kilani-Morakchi et al, 2021). For maintaining dental hygiene by chewing sticks, millions of rural as well as urban people use neem twigs (Gupta et al, 2017).…”

A comparison between solvent casting and electrospinning methods for the fabrication of neem extract-containing buccal films

“…In other words, neem extract can successfully treat various oral-based problems such as infections, tooth decay and bleeding. Hence, using neem extract in a mucoadhesive buccal film can effectively control the dental and oral problems [26,27]. In addition, neem extract is an appealing material for reducing pain and inflammation due to the presence of a main bioactive compound known as "limonoid".…”

Miodla indyjska (Azadirachta indica) – znaczenie gospodarcze oraz zastosowanie w kosmetyce i lecznictwie

“…częściej sięgają po surowce roślinne o właściwościach leczniczych [1,2,3]. Według badań Krochmal-Marczak i wsp.…”