Evolución del estado nutricional, parámetros inmunológicos y virológicos en niños con VIH de transmisión vertical bajo tratamiento antirretroviral

Oberto, María Georgina; Asis, Elizabeth Liliana; Defagó, María Daniela

doi:10.31053/1853.0605.v78.n4.28147

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…In our study, only 2 patients were able to bene t from the convenience of co-formulated drugs (2 adolescent patients who were prescribed Biktarvy® [FTC-TAF-BIC]). Consistent with recent publications 25 , the most frequent adverse effect in our study was lipid pro le abnormalities, which was associated with the use of boosted protease inhibitors or EFV.…”

Section: Discussionsupporting

confidence: 92%

Follow-up of New Diagnoses of Mother-to-child Transmission of HIV in 2018 in 8 Latin American Countries in the Plantaids Cohort: 3 Years Later

Vallejo,

Lobo,

García

et al. 2023

Preprint

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Introduction: The frequency of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) in Latin America has decreased considerably. However, new infections continue to be recorded, and the pediatric population remains one of the most vulnerable groups in this region. The main objective of the study was to describe the evolution of new diagnoses of HIV MTCT in 2018 in the PLANTAIDS network (Paediatric Network for Prevention, Early Detection and Treatment of HIV in Children) during the 3 years following diagnosis. Methodology: Retrospective, multicenter, descriptive study based on a 3-year follow-up of patients diagnosed with HIV infection due to MTCT in 2018 in 10 hospitals in 8 Latin American countries (Costa Rica, Ecuador, Mexico, Honduras, El Salvador, Panama, Guatemala and Venezuela). The hospitals belonged to the PLANTAIDS network, which is included in CYTED (Ibero-American Programme of Science and Technology for Development). Results: The study population comprised 72 pediatric patients (38.9% male). The median age at diagnosis was 2.4 years (IQR: 0.8-5.4). There were 35 cases of opportunistic infections corresponding to 25 patients (34.7%), with tuberculosis being the most common. Adequate childhood vaccination coverage was achieved in 80.5%. There were 3 cases of acute SARS-CoV-2 infection, and these were asymptomatic or mildly symptomatic. According to the Centers for Disease Control and Prevention(CDC) classification, the most frequent clinical-immunological stage at all check-ups was C1. Three patients died from opportunistic infections and/or advanced HIV infection. Conclusions: HIV infection has a poor prognosis in children, necessitating adequate follow-up to ensure adherence to health care and ART. However, this can be difficult at times in pediatrics. In our study, SARS-CoV-2 infection did not appear to be severe in children with HIV.

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Section: Discussionsupporting

confidence: 92%

Follow-up of New Diagnoses of Mother-to-child Transmission of HIV in 2018 in 8 Latin American Countries in the Plantaids Cohort: 3 Years Later

Vallejo,

Lobo,

García

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…In our study, only 2 patients were able to benefit from the convenience of co-formulated drugs (2 adolescent patients who were prescribed Biktarvy® [FTC-TAF-BIC]). Consistent with recent publications [ 30 ], the most frequent adverse effect in our study was lipid profile abnormalities, which was associated with the use of boosted protease inhibitors or EFV.…”

Section: Discussionsupporting

confidence: 92%

“…As for children older than 5 years, the figures are not so striking, and only 4.2% of the patients had a BMI in a percentile lower than 3. Although the delay in growth and lower scores than expected in terms of weight and height are the most frequent observations, some studies also present data on overweight and obesity in children living with HIV [ 30 , 43 ]. In our case, the highest number of patients under 5 years of age with a weight percentile greater than 97 (2.6%) was obtained at the second check-up, with lower figures found at the other 3 check-ups.…”

Section: Discussionmentioning

confidence: 99%

Follow-up for 3 years of a pediatric population diagnosed in 2018 with mother-to-child transmission of HIV in 8 Latin American countries in the PLANTAIDS cohort

Vallejo,

Lobo,

García

et al. 2024

BMC Infect Dis

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Introduction The frequency of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) in Latin America has decreased considerably. However, new infections continue to be recorded, and the pediatric population remains one of the most vulnerable groups in this region. The main objective of the study was to describe the clinical, epidemiological and psychosocial characteristics of new diagnoses of HIV MTCT in 2018 in the PLANTAIDS network (Paediatric Network for Prevention, Early Detection and Treatment of HIV in Children) during the 3 years following diagnosis. Methodology Retrospective, multicenter, descriptive study based on a 3-year follow-up of patients diagnosed with HIV infection due to MTCT in 2018 in 10 hospitals in 8 Latin American countries (Costa Rica, Ecuador, Mexico, Honduras, El Salvador, Panama, Guatemala and Venezuela). The hospitals belonged to the PLANTAIDS network, which is included in CYTED (Ibero-American Programme of Science and Technology for Development). Results The study population comprised 72 pediatric patients (38.9% male). The median age at diagnosis was 2.4 years (IQR: 0.8–5.4). There were 35 cases of opportunistic infections corresponding to 25 patients (34.7%), with tuberculosis being the most common. Adequate childhood vaccination coverage was achieved in 80.5%. There were 3 cases of acute SARS-CoV-2 infection, and these were asymptomatic or mildly symptomatic. According to the Centers for Disease Control and Prevention (CDC) classification, the most frequent clinical-immunological stage at all check-ups was C1. Three patients died from opportunistic infections and/or advanced HIV infection. Conclusions It is important to diagnose HIV infection early in pediatrics, since early initiation of ART is associated with a decrease in mortality. Despite this, HIV infection has a poor prognosis in children, necessitating adequate follow-up to ensure adherence to health care and ART, although it can sometimes prove difficult in children.

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“…En la investigación se pudo observar el tratamiento antirretroviral para VIH, entre eso se encontraron diferentes fármacos como el abacavir, el nelfinavir, etravirina, la kaletra, didanosina, lamivudina y la Zidovudina, es importante destacar que los adolescentes enfrentan desafíos con respecto al cuidado, lo que afecta en gran medida al tratamiento. En los estudios analizados en la presente investigación, Oberto y col. (Oberto et al, 2021). Mencionaron que el tratamiento de elección para los pacientes con VIH correspondió Nelfinavir, estavudina, nevirapina, raltegravir, lamivudina, abacavir.…”

Section: Discussionunclassified

Prevención, diagnóstico y tratamiento del VIH en niños y jóvenes de Latinoamérica.

Santos¹,

Zambrano²,

Vélez³

2023

MQRInvestigar

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El Virus de Inmunodeficiencia Humana, se los define como un retrovirus, el cual se caracteriza por infectar a las células del sistema inmunitario, principalmente a las células T CD4+ y a los macrófagos, los cuales son un componente clave del sistema inmunitario celular. Cuando esta patología no se controla con los antirretrovirales, esta infección puede deteriorar al sistema inmunológico de una forma gradual. El objetivo del estudio fue analizar la prevención, diagnóstico y tratamiento antirretroviral del Virus de Inmunodeficiencia Humana en niños y adolescentes de Latinoamérica. La metodología de este fue documental y el tipo de estudio es informativo. Se realizó una búsqueda literaria relevante sobre el tema a tratar. Para poder tener dicha información se utilizaron bases de datos como: Pubmed, Dialnet, SciELO, Redalyc, ELSEVIER y Medigraphic. Los filtros utilizados para la búsqueda fueron los términos meSH y el boleano “and”. Como resultados y conclusiones del estudio, se obtuvieron los siguientes, Existen diferentes formas de prevención del virus de inmunodeficiencia humana, entre esas se encuentran las charlas preventivas, uso de protección durante las relaciones sexuales y tener solo una pareja sexual. Así mismo, las pruebas diagnósticas para el virus son numerosas, entre esas se encuentran las pruebas de ELISA de tercera y cuarta generación, pruebas serológicas y pruebas rápidas. Por último, el tratamiento antirretroviral para el virus de inmunodeficiencia humana generalmente suele ser el mismo para todos, entre eso se encuentran el abacavir, el nelfinavir, etravirina, la kaletra, didanosina y lamivudina.

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Evolución del estado nutricional, parámetros inmunológicos y virológicos en niños con VIH de transmisión vertical bajo tratamiento antirretroviral

Cited by 5 publications

References 13 publications

Follow-up of New Diagnoses of Mother-to-child Transmission of HIV in 2018 in 8 Latin American Countries in the Plantaids Cohort: 3 Years Later

Follow-up of New Diagnoses of Mother-to-child Transmission of HIV in 2018 in 8 Latin American Countries in the Plantaids Cohort: 3 Years Later

Follow-up for 3 years of a pediatric population diagnosed in 2018 with mother-to-child transmission of HIV in 8 Latin American countries in the PLANTAIDS cohort

Prevención, diagnóstico y tratamiento del VIH en niños y jóvenes de Latinoamérica.

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