Evoked response correlates of psychophysical magnitude estimates for tactile stimulation in man

Franzén, Ove; Offenloch, Kurt

doi:10.1007/bf00234922

Cited by 113 publications

(15 citation statements)

References 48 publications

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“…doubling the input amplitude results in a doubled output amplitude), whereas in a nonlinear system both the shape and amplitude of the response will vary with applied stimulus amplitude. Several studies on mechanically somatosensory responses show that the shape of the ERP changes with the amplitude of the mechanical stimulus [41][42][43][44]. Due to this nonlinear behavior of the system (also shown in our results) the shape of the response and subsequently the timing of characteristic peaks will change with a change in amplitude of the sensory stimulus.…”

Section: Discussionsupporting

confidence: 75%

Quantifying Nonlinear Contributions to Cortical Responses Evoked by Continuous Wrist Manipulation

Vlaar

Solis‐Escalante

Vardy

et al. 2017

IEEE Trans. Neural Syst. Rehabil. Eng.

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Abstract-Cortical responses to continuous stimuli as recorded using either magneto-or electroencephalography (EEG) have shown power at harmonics of the stimulated frequency, indicating nonlinear behavior. Even though the selection of analysis techniques depends on the linearity of the system under study, the importance of nonlinear contributions to cortical responses has not been formally addressed. The goal of this paper is to quantify the nonlinear contributions to the cortical response obtained from continuous sensory stimulation. EEG was used to record the cortical response evoked by continuous movement of the wrist joint of healthy subjects applied with a robotic manipulator. Multisine stimulus signals (i.e. the sum of several sinusoids) elicit a periodic cortical response and allow to assess the nonlinear contributions to the response. Wrist dynamics (relation between joint angle and torque) were successfully linearized, explaining 99% of the response. In contrast, the cortical response revealed a highly nonlinear relation; where most power (~80%) occurred at nonstimulated frequencies. Moreover, only 10% of the response could be explained using a nonparametric linear model. These results indicate that the recorded evoked cortical responses are governed by nonlinearities and that linear methods do not suffice when describing the relation between mechanical stimulus and cortical response.

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Section: Discussionsupporting

confidence: 75%

Quantifying Nonlinear Contributions to Cortical Responses Evoked by Continuous Wrist Manipulation

Vlaar

Solis‐Escalante

Vardy

et al. 2017

IEEE Trans. Neural Syst. Rehabil. Eng.

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“…The positive peak in the potentials recorded with C4-Fpz {P30) corresponded in latency to the potentials recorded from the scalp overlying the somatosensory cortex as previously reported (Kjellman et al 1967;Franzen and Offenloch 1969;Larsson and Prevec 1970;Nakanishi et al 1973). The comparable latencies of N38 and P47, recorded by C4-Fpz, and of N37 and P43 recorded by CIIFpz and their absence in the Oz-CII recordings, support the suggestion that this complex was also generated at the cortical level, most probably in the frontal region.…”

Section: Discussionsupporting

confidence: 81%

Short latency mechanically evoked somatosensory potentials in humans

Pratt

Amlie

Starr

1979

Electroencephalography and Clinical Neurophysiology

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“…Other MEG studies examined directly the cortical adaptation in the primary and/or secondary somatosensory areas using trains of electrical stimuli (Hamada et al 2002; Ou et al 2009). Despite the common use of electrical stimulation, the potential advantages of more selective activation of the cutaneous afferents using tactile stimuli have been widely acknowledged (Franzén and Offenloch 1969; Pratt et al 1980; Hashimoto et al 1990). Electrical stimulation bypasses the sensory skin receptors and entrains undifferentiated afferents and motor efferent fibers, altering the adaptation mechanisms at subcortical and cortical levels due to abnormal lateral inhibition (Willis and Coggeshall 1991).…”

Section: Introductionmentioning

confidence: 99%

Adaptive changes in the neuromagnetic response of the primary and association somatosensory areas following repetitive tactile hand stimulation in humans

Popescu

Barlow

Venkatesan

et al. 2012

Human Brain Mapping

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Cortical adaptation in the primary somatosensory cortex (SI) has been probed using different stimulation modalities and recording techniques, in both human and animal studies. In contrast, considerably less knowledge has been gained about the adaptation profiles in other areas of the cortical somatosensory network. Using magnetoencephalography, we examined the patterns of short-term adaptation for evoked responses in SI and somatosensory association areas during tactile stimulation applied to the glabrous skin of the right hand. Cutaneous stimuli were delivered as trains of serial pulses with a constant frequency of 2 Hz and 4 Hz in separate runs, and a constant inter-train interval of 5 s. The unilateral stimuli elicited transient responses to the serial pulses in the train, with several response components that were separated by Independent Component Analysis. Subsequent neuromagnetic source reconstruction identified regional generators in the contralateral SI and somatosensory association areas in the posterior parietal cortex (PPC). Activity in the bilateral secondary somatosensory cortex (i.e. SII/PV) was also identified, although less consistently across subjects. The dynamics of the evoked activity in each area and the frequency-dependent adaptation effects were assessed from the changes in the relative amplitude of serial responses in each train. We show that the adaptation profiles in SI and PPC can be quantitatively characterized from neuromagnetic recordings using tactile stimulation, with the sensitivity to repetitive stimulation increasing from SI to PPC. A similar approach for SII/PV has proven less straightforward, potentially due to the selective nature of these areas to respond predominantly to certain stimuli.

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Evoked response correlates of psychophysical magnitude estimates for tactile stimulation in man

Cited by 113 publications

References 48 publications

Quantifying Nonlinear Contributions to Cortical Responses Evoked by Continuous Wrist Manipulation

Quantifying Nonlinear Contributions to Cortical Responses Evoked by Continuous Wrist Manipulation

Short latency mechanically evoked somatosensory potentials in humans

Adaptive changes in the neuromagnetic response of the primary and association somatosensory areas following repetitive tactile hand stimulation in humans

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