Evoked Potentials and P<sub>300</sub> during Sensory Conditioning in Autistic Children

Martineau, J.; Garreau, B.; Barthélémy, C.; G, Lelord

doi:10.1111/j.1749-6632.1984.tb23557.x

Cited by 29 publications

(26 citation statements)

References 16 publications

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“…The disorder seems to include defects in recognizing or making classifications (Hermelin, 1976;Rutter, 1978;Hoffmann & Prior, 1982) and defects in mechanisms of attention and orienting to novel stimulation (Gold & Gold, 1975;James & Barry, 1980;Kootz & Cohen, 1981). Opinions remain divided as to whether the defects in orienting are principally characterized by increased or decreased sensitivity to events, or both.Recent studies of event-related brain potentials (ERPs) support the idea that autism involves deficits in information processing (Novick, Kurtzberg, & Vaughan, 1979;Novick, Vaughan, Kurtzberg, & Simson, 1980;Martineau, Garreau, Barthelemy, & Lelord, 1981;Courchesne, Kilman, Galambos, & Lincoln, 1984). Novick et al (1979) reported that both visual and auditory ERPs were abnormal in autistic adolescents.…”

mentioning

confidence: 96%

Event-related brain potential correlates of the processing of novel visual and auditory information in autism

Courchesne

Lincoln

Kilman³

et al. 1985

J Autism Dev Disord

173

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Event-related brain potentials (ERPs) elicited by visual and auditory stimuli were recorded from nonretarded individuals with autism (ages 13-25 years) and age-matched normal controls. In "no-task" conditions, subjects simply looked at or listened to these stimuli; only one difference was found between subject groups. Several ERP differences between groups were found in "task" conditions; subjects pressed a button at the occurrence of target stimuli intermixed with unexpected, novel stimuli and also with expected, nonnovel stimuli. Visual ERP abnormalities in the autistic group differed from auditory abnormalities. Results suggest that (1) nonretarded autistic individuals may have a limited capacity to process novel information--they are neither hypersensitive to novel information nor misperceive it as nonnovel and insignificant; (2) classification of simple visual information may be less impaired than auditory; and (3) with one exception, visual and auditory ERP abnormalities do not seem to reflect maturational delay.

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mentioning

confidence: 96%

Event-related brain potential correlates of the processing of novel visual and auditory information in autism

Courchesne

Lincoln

Kilman³

et al. 1985

J Autism Dev Disord

173

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“…In this study, although responses were equally accurate and rapid between the autism group and typical controls, amplitudes were smaller among those with autism (Novick et al 1980). Some years later, Martineau et al (1984) performed a study in which repeated auditory and visual stimuli were presented in succession to low-functioning children with autism, compared to age matched controls. Children with autism had significantly shorter latencies of the P1, N1, P2 and P3 components (Martineau et al 1984).…”

Section: Low-level Auditory Processingmentioning

confidence: 99%

“…Some years later, Martineau et al (1984) performed a study in which repeated auditory and visual stimuli were presented in succession to low-functioning children with autism, compared to age matched controls. Children with autism had significantly shorter latencies of the P1, N1, P2 and P3 components (Martineau et al 1984). In an ACRT task with high functioning children, Oades et al found a shorter N1 latency with normal performance in autism compared to age matched controls (Oades et al 1988(Oades et al , 1990.…”

Section: Low-level Auditory Processingmentioning

confidence: 99%

Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review

Jeste

Nelson

2008

J Autism Dev Disord

160

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In this paper we critically review the literature on the use of event related potentials (ERPs) to elucidate the neural sources of the core deficits in autism. We review auditory and visual ERP studies, and then review the use of ERPs in the investigation of executive function. We conclude that, in autism, impairments likely exist in both low and higher level auditory and visual processing, with prominent impairments in the processing of social stimuli. We also discuss the putative neural circuitry underlying these deficits. As we look to the future, we posit that tremendous insight can be gained by applying ERPs to the definition of endophenotypes, which, in turn, can facilitate early diagnosis and the creation of informed interventions for children with autism. KeywordsEvent related potential (ERP); Autism; Auditory processing; Visual processing Since autism was first described by Kanner over fifty years ago (Kanner 1943), the neurobiology of this disorder has become the focus of intense scientific investigation. While extensive efforts have been made in describing the behaviors that define autism, only in recent years has progress been made to elucidate the underlying neural circuitry involved in autism, through structural and, more recently, functional neuroimaging. Through these studies has come a heightened interest in aberrant neural circuitry in autism. Of the neuroimaging tools that have been used to elucidate brain circuitry, functional electrophysiology stands alone in capacity to define early (i.e. in infancy) neural markers and endophenotypes. This technique, therefore, warrants further scrutiny. Using functional electrophysiology, defined by evoked potentials and then by event related potentials (ERPs), researchers have begun to elucidate sources of the core deficits in autism

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“…Interestingly, P3 is also either abnormal or absent in autism (Novick et al 1979;Martineau et al 1983;Courchesne et al 1984). Not only are medial temporal lobe abnormalities postulated in this condition (Hauser et al 1975;Damasio and Maurer 1978), but fragile sites on the X chromosome have been found in autistic males (Brown et al 1982;Meryash et al 1982;Goldfine et al 1985).…”

Section: Introductionmentioning

confidence: 99%

P3 Abnormality in fragile X syndrome

Clair

Blackwood

Oliver

et al. 1987

Biological Psychiatry

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Evoked Potentials and P₃₀₀ during Sensory Conditioning in Autistic Children

Cited by 29 publications

References 16 publications

Event-related brain potential correlates of the processing of novel visual and auditory information in autism

Event-related brain potential correlates of the processing of novel visual and auditory information in autism

Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review

P3 Abnormality in fragile X syndrome

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Evoked Potentials and P300 during Sensory Conditioning in Autistic Children

Cited by 29 publications

References 16 publications

Event-related brain potential correlates of the processing of novel visual and auditory information in autism

Event-related brain potential correlates of the processing of novel visual and auditory information in autism

Event Related Potentials in the Understanding of Autism Spectrum Disorders: An Analytical Review

P3 Abnormality in fragile X syndrome

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Product

Resources

About

Evoked Potentials and P₃₀₀ during Sensory Conditioning in Autistic Children