Evodiamine and rutaecarpine from Tetradium ruticarpum in the treatment of liver diseases

Li, Xiaojiaoyang; Ge, Junde; Zheng, Qi; Zhang, Jiaxiang; Sun, Rong; Liu, Runping

doi:10.1016/j.phymed.2020.153180

Cited by 50 publications

(33 citation statements)

References 74 publications

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“…Simultaneously, various therapeutic activities have been ascribed to alkaloids, including antioxidant, cancer-preventive, antidiabetic, anti-inflammatory, and vasodilatory activities (252)(253)(254), but it has not been well-investigated how livestock could benefit from these beneficial activities from alkaloids. Many plant extracts that have been investigated for the beneficial actions of contained polyphenols and terpenoids may also contain alkaloids contributing to their biological activities, for example, giant milkweed (255) or herbal mixtures containing polyphenols, terpenoids, and alkaloids (256).…”

Section: Nutritional Importancementioning

confidence: 99%

Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

Tedeschi

Muir²,

Naumann

et al. 2021

Front. Vet. Sci.

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This review provides an update of ecologically relevant phytochemicals for ruminant production, focusing on their contribution to advancing nutrition. Phytochemicals embody a broad spectrum of chemical components that influence resource competence and biological advantage in determining plant species' distribution and density in different ecosystems. These natural compounds also often act as plant defensive chemicals against predatorial microbes, insects, and herbivores. They may modulate or exacerbate microbial transactions in the gastrointestinal tract and physiological responses in ruminant microbiomes. To harness their production-enhancing characteristics, phytochemicals have been actively researched as feed additives to manipulate ruminal fermentation and establish other phytochemoprophylactic (prevent animal diseases) and phytochemotherapeutic (treat animal diseases) roles. However, phytochemical-host interactions, the exact mechanism of action, and their effects require more profound elucidation to provide definitive recommendations for ruminant production. The majority of phytochemicals of nutritional and pharmacological interest are typically classified as flavonoids (9%), terpenoids (55%), and alkaloids (36%). Within flavonoids, polyphenolics (e.g., hydrolyzable and condensed tannins) have many benefits to ruminants, including reducing methane (CH4) emission, gastrointestinal nematode parasitism, and ruminal proteolysis. Within terpenoids, saponins and essential oils also mitigate CH4 emission, but triterpenoid saponins have rich biochemical structures with many clinical benefits in humans. The anti-methanogenic property in ruminants is variable because of the simultaneous targeting of several physiological pathways. This may explain saponin-containing forages' relative safety for long-term use and describe associated molecular interactions on all ruminant metabolism phases. Alkaloids are N-containing compounds with vast pharmacological properties currently used to treat humans, but their phytochemical usage as feed additives in ruminants has yet to be exploited as they may act as ghost compounds alongside other phytochemicals of known importance. We discussed strategic recommendations for phytochemicals to support sustainable ruminant production, such as replacements for antibiotics and anthelmintics. Topics that merit further examination are discussed and include the role of fresh forages vis-à-vis processed feeds in confined ruminant operations. Applications and benefits of phytochemicals to humankind are yet to be fully understood or utilized. Scientific explorations have provided promising results, pending thorough vetting before primetime use, such that academic and commercial interests in the technology are fully adopted.

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Section: Nutritional Importancementioning

confidence: 99%

Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

Tedeschi

Muir²,

Naumann

et al. 2021

Front. Vet. Sci.

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“…For example, Tetradium ruticarpum is the most common ethnoveterinary medicinal plant in Southwest China, and its fruits are used for the treatment of gastrointestinal disorders, such as gastric distension, diarrhea, and stomach overload [41]. Recently, literature has indicated that evodiamine and rutaecarpine from Tetradium ruticarpum could be used for the treatment of liver diseases [42].…”

Section: The Urs Value Of Ethnoveterinary Medicinal Plantsmentioning

confidence: 99%

An ethnoveterinary study on medicinal plants used by the Buyi people in Southwest Guizhou, China

Xiong

Long

2020

J Ethnobiology Ethnomedicine

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Background: The Buyi (Bouyei) people in Qianxinan Buyi and Miao Autonomous Prefecture, Southwest Guizhou, China, have used medicinal plants and traditional remedies for ethnoveterinary practices, such as treating domestic animals during livestock breeding, since ancient times. However, the unique ethnoveterinary practices of the Buyi have rarely been recorded. This study aimed to identify the plants used in their traditional ethnoveterinary practices, and to propose suggestions for future conservation and sustainable use of this knowledge. Methods: Ethnobotanical fieldwork was conducted in 19 villages/townships in Qianxinan Prefecture between 2017 and 2018. Data were collected from the local Buyi people through semi-structured interviews and participatory observations. The informant consensus factor (FIC) and use reports (URs) were utilized to evaluate the consent of the current ethnoveterinary practices among the local communities, and 83 informants were interviewed during the field investigations. Plant samples and voucher specimens were collected for taxonomic identification. Results: A total of 122 plant species, belonging to 60 families and 114 genera, were recorded as being used in ethnoveterinary practices by the Buyi people. The most used ethnoveterinary medicinal plant (EMP) parts included the roots, whole plant, and bulb, and the most common preparation methods included decoction, crushing, and boiling. Some EMPs, such as Quisqualis indica and Paris polyphylla, have special preparation methods. The informant consensus factor (FIC) and use reports (URs) of the EMP species were analyzed. Twenty EMP species with the highest URs were noted as having particular importance in the daily lives of Buyi people in Qianxinan Prefecture. Conclusion: In this study, we identified traditional ethnoveterinary knowledge of the medicinal plants among the Buyi communities in Qianxinan Prefecture. This knowledge has previously been limited to local vets, herders, and aged community members. Plants with important medicinal uses need to be validated phytochemically and pharmacologically in the future, to develop new alternative drugs for veterinary purposes.

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“…Evodiamine, dehydroevodiamine, and rutaecarpine are three major bioactive components of Evodia rutaecarpine ( Zhang Y. et al, 2018 ; Zhang et al, 2020 ). Their effects on cardiovascular protection, hepatic lipid metabolism regulation, liver injury protection, degenerative neurological diseases improvement, and acute pancreatitis protection have been fully recorded ( Yan et al, 2018 ; Tian et al, 2019 ; Li et al, 2020 ; Zhao B. et al, 2020 ). Recently, some studies have found that evodiamine and rutaecarpine also have anti-tumor activity in vivo and in vitro experiments, which can induce apoptosis and inhibit the proliferation, invasion, and metastasis of a variety of tumors ( Ogasawara et al, 2001 ; Jiang and Hu, 2009 ; Yang et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Rutaecarpine Inhibits U87 Glioblastoma Cell Migration by Activating the Aryl Hydrocarbon Receptor Signaling Pathway

Liu

Chen

Zhu

et al. 2021

Front. Mol. Neurosci.

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Glioblastoma is the most frequent and aggressive primary astrocytoma in adults. The high migration ability of the tumor cells is an important reason for the high recurrence rate and poor prognosis of glioblastoma. Recently, emerging evidence has shown that the migration ability of glioblastoma cells was inhibited upon the activation of aryl hydrocarbon receptor (AhR), suggesting potential anti-tumor effects of AhR agonists. Rutaecarpine is a natural compound with potential tumor therapeutic effects which can possibly bind to AhR. However, its effect on the migration of glioblastoma is unclear. Therefore, we aim to explore the effects of rutaecarpine on the migration of human glioblastoma cells U87 and the involvement of the AhR signaling pathway. The results showed that: (i) compared with other structural related alkaloids, like evodiamine and dehydroevodiamine, rutaecarpine was a more potent AhR activator, and has a stronger inhibitory effect on the glioblastoma cell migration; (ii) rutaecarpine decreased the migration ability of U87 cells in an AhR-dependent manner; (iii) AhR mediated the expression of a tumor suppressor interleukin 24 (IL24) induced by rutaecarpine, and AhR-IL24 axis was involved in the anti-migratory effects of rutaecarpine on the glioblastoma. Besides IL24, other candidates AhR downstream genes both associated with cancer and migration were proposed to participate in the migration regulation of rutaecarpine by RNA-Seq and bioinformatic analysis. These data indicate that rutaecarpine is a naturally-derived AhR agonist that could inhibit the migration of U87 human glioblastoma cells mostly via the AhR-IL24 axis.

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Evodiamine and rutaecarpine from Tetradium ruticarpum in the treatment of liver diseases

Cited by 50 publications

References 74 publications

Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production

An ethnoveterinary study on medicinal plants used by the Buyi people in Southwest Guizhou, China

Rutaecarpine Inhibits U87 Glioblastoma Cell Migration by Activating the Aryl Hydrocarbon Receptor Signaling Pathway

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