Evodiamine: A review of its pharmacology, toxicity, pharmacokinetics and preparation researches

Sun, Qiang; Xie, Long; Song, Jung Soo; Li, Xiaofang

doi:10.1016/j.jep.2020.113164

Cited by 73 publications

(44 citation statements)

References 204 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When evaluating the efficacy of ingredients, the toxicity and safety of them should be considered particularly ( Sun et al, 2020b ). For a long time, traditional Chinese medicine (TCM) is well known for its safety.…”

Section: Toxicitymentioning

confidence: 99%

Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity

Zhang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Oridonin, as a natural terpenoids found in traditional Chinese herbal medicine Isodon rubescens (Hemsl.) H.Hara, is widely present in numerous Chinese medicine preparations. The purpose of this review focuses on providing the latest and comprehensive information on the pharmacology, pharmacokinetics and toxicity of oridonin, to excavate the therapeutic potential and explore promising ways to balance toxicity and efficacy of this natural compound. Information concerning oridonin was systematically collected from the authoritative internet database of PubMed, Elsevier, Web of Science, Wiley Online Library and Europe PMC applying a combination of keywords involving “pharmacology,” “pharmacokinetics,” and “toxicology”. New evidence shows that oridonin possesses a wide range of pharmacological properties, including anticancer, anti-inflammatory, hepatorenal activities as well as cardioprotective protective activities and so on. Although significant advancement has been witnessed in this field, some basic and intricate issues still exist such as the specific mechanism of oridonin against related diseases not being clear. Moreover, several lines of evidence indicated that oridonin may exhibit adverse effects, even toxicity under specific circumstances, which sparked intense debate and concern about security of oridonin. Based on the current progress, future research directions should emphasize on 1) investigating the interrelationship between concentration and pharmacological effects as well as toxicity, 2) reducing pharmacological toxicity, and 3) modifying the structure of oridonin—one of the pivotal approaches to strengthen pharmacological activity and bioavailability. We hope that this review can provide some inspiration for the research of oridonin in the future.

show abstract

Section: Toxicitymentioning

confidence: 99%

Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity

Zhang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Evodiamine, a naturally occurring alkaloid with quinazolinocarboline skeleton, originates from numerous herbs including Evodia rutaecarpa ( Liu et al, 2019b ) and Euonymus europaeus ( Sevastre et al, 2017 ). In recent years, there have been increasing studies on its anti-CRC effect ( Sun et al, 2020b ). Evodiamine suppressed the proliferation of CRC cells HT29, HCT15, and SW480 and induced apoptosis by cell cycle arrest in the G 2 /M phase, as well as suppressed the expression of cancer-stem-cell-related genes ( Kim et al, 2019a ).…”

Section: Antitumor Status Of Traditional Chinese Medicine and Its Clinical Trials On Colorectal Cancermentioning

confidence: 99%

Traditional Chinese Medicine and Colorectal Cancer: Implications for Drug Discovery

Sun

Zhang

et al. 2021

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

As an important part of complementary and alternative medicine, traditional Chinese medicine (TCM) has been applied to treat a host of diseases for centuries. Over the years, with the incidence rate of human colorectal cancer (CRC) increasing continuously and the advantage of TCM gradually becoming more prominent, the importance of TCM in both domestic and international fields is also growing with each passing day. However, the unknowability of active ingredients, effective substances, and the underlying mechanisms of TCM against this malignant tumor greatly restricts the translation degree of clinical products and the pace of precision medicine. In this review, based on the characteristics of TCM and the oral administration of most ingredients, we herein provide beneficial information for the clinical utilization of TCM in the prevention and treatment of CRC and retrospect the current preclinical studies on the related active ingredients, as well as put forward the research mode for the discovery of active ingredients and effective substances in TCM, to provide novel insights into the research and development of innovative agents from this conventional medicine for CRC treatment and assist the realization of precision medicine.

show abstract

“…A famous pill called Zuojin Pills, containing EVO, could be used for hepatocellular carcinoma treatment [ 31 ]. However, its clinic application was greatly hampered by its hydrophobicity, low oral bioavailability, short half-life period, and poor understanding of antitumor mechanisms and potential side effects on hepatic cells and cardiac cells [ 32 ]. To solve the hydrophobicity, Wang et al developed GE11-Evo-NPs that were confirmed soluble and better retained cancer cell cytotoxicity than free EVO [ 33 ].…”

Section: Introductionmentioning

confidence: 99%