Evidenzbasierte Diagnostik hereditärer Netzhautdystrophien 2009

Kellner, Ulrich; Kellner, Simone; Renner, Agnes B.; Fiebig, Britta; Weinitz, Silke; Weber, Bernhard H. F.

doi:10.1055/s-0028-1109684

Cited by 1 publication

(1 citation statement)

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“…The excitation and emission spectra of melanin lie in the range of indocyanine green (ICG). The importance of NIR-AF has been addressed in a range of eye diseases [9,13,14,15,16,17,18,19,20,21,22,23]. NIR-AF demonstrating the allocation of melanin in vivo is a special option to study the melanin-rich RPE, which is thought to play a crucial role in CSC.…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Autofluorescence and Indocyanine Green Angiography in Central Serous Chorioretinopathy

Lindner

Weinberger²,

Kirschkamp

et al. 2011

Ophthalmologica

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Purpose: To evaluate the diagnostic potential of near-infrared (NIR) autofluorescence (AF) in central serous chorioretinopathy (CSC) and to present a method to analyze NIR-AF findings quantitatively. Procedures: NIR-AF images, indocyanine green (ICG) angiograms, blue-light autofluorescence (BL-AF) images and fluorescein angiograms were recorded with the use of a confocal scanning laser ophthalmoscope in 19 eyes of 17 patients with CSC. Gray-value ratios were calculated to compare the methods. Results: Using NIR-AF, hypofluorescent spots were observed at the leakage site in 18 of 19 eyes (94.7%). The mean gray-value ratio (±SD) was 0.55 ± 0.22 for the site of the leakage point with NIR-AF and 0.65 ± 0.35 with BL-AF. ICG angiography showed a gray-value ratio of 2.37 ± 2.07. Fluorescein angiography had the best contrast, with a gray-value ratio of 13.44 ± 15.02. Conclusion: NIR-AF demonstrated CSC in 94.7% of the cases. NIR-AF may be a noninvasive alternative to detect CSC.

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