Evidencing different neurochemical profiles between thalamic nuclei using high resolution 2D-PRESS semi-LASER 1H-MRSI at 7 T

Donadieu, Maxime; Fur, Yann Le; Confort‐Gouny, Sylviane; Troter, Arnaud Le; Guye, Maxime; Ranjeva, Jean‐Philippe

doi:10.1007/s10334-016-0556-1

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…Similarly, White et al found a higher signal ratio in the left pulvinar compared with the right on T 2 ‐weighted images and the opposite for the globus‐pallidus (White et al, 2014). A recent study has shown metabolite differences in each thalamic nuclei and between hemispheres using 1 H‐magnetic resonance spectroscopy that could be explained by cellular, functional and structural differences (Donadieu et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Automatic segmentation of deep grey nuclei using a high‐resolution 7T magnetic resonance imaging atlas—Quantification of T1 values in healthy volunteers

Brun

Testud

Girard

et al. 2022

Eur J of Neuroscience

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We present a new consensus atlas of deep grey nuclei obtained by shape‐based averaging of manual segmentation of two experienced neuroradiologists and optimized from 7T MP2RAGE images acquired at (.6 mm)3 in 60 healthy subjects. A group‐wise normalization method was used to build a high‐contrast and high‐resolution T1‐weighted brain template (.5 mm)3 using data from 30 out of the 60 controls. Delineation of 24 deep grey nuclei per hemisphere, including the claustrum and 12 thalamic nuclei, was then performed by two expert neuroradiologists and reviewed by a third neuroradiologist according to tissue contrast and external references based on the Morel atlas. Corresponding deep grey matter structures were also extracted from the Morel and CIT168 atlases. The data‐derived, Morel and CIT168 atlases were all applied at the individual level using non‐linear registration to fit the subject reference and to extract absolute mean quantitative T1 values derived from the 3D‐MP2RAGE volumes, after correction for residual B1+ biases. Three metrics (the Dice and the volumetric similarity coefficients and a novel Hausdorff distance) were used to estimate the inter‐rater agreement of manual MRI segmentation and inter‐atlas variability, and these metrics were measured to quantify biases due to image registration, and their impact on the measurements of the quantitative T1 values was highlighted. This represents a fully automated segmentation process permitting the extraction of unbiased normative T1 values in a population of young healthy controls as a reference for characterizing subtle structural alterations of deep grey nuclei relevant to a range of neurological diseases.

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Section: Discussionmentioning

confidence: 99%

Automatic segmentation of deep grey nuclei using a high‐resolution 7T magnetic resonance imaging atlas—Quantification of T1 values in healthy volunteers

Brun

Testud

Girard

et al. 2022

Eur J of Neuroscience

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“…The issue provides an overview of the state of the art and discusses the clinical relevance of what we have already observed and can clearly foresee. Articles are devoted to development of novel methodology [12][13][14][15][16], safety topics [17][18][19] early multicenter trials [20], frontier human studies [21][22][23][24][25][26][27][28], breakthrough clinical applications [29][30][31][32][33][34][35][36] and future directions of UHF-MR [37,38]. At the moment some of these new concepts and clinical applications are merely of proof-of-principle nature and visions, but they are compelling enough to drive the field forward.…”

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confidence: 99%

From ultrahigh to extreme field magnetic resonance: where physics, biology and medicine meet

Niendorf

Barth

Kober

et al. 2016

Magn Reson Mater Phy

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UHF-MR can see a clear route forward for resolving technological issues and can outline some of the new opportunities that will accompany even higher field strengths. The issue provides an overview of the state of the art and discusses the clinical relevance of what we have already observed and can clearly foresee. Articles are devoted to development of novel methodology [12][13][14][15][16], safety topics [17][18][19] early multicenter trials [20], frontier human studies [21][22][23][24][25][26][27][28], breakthrough clinical applications [29][30][31][32][33][34][35][36] and future directions of UHF-MR [37,38]. At the moment some of these new concepts and clinical applications are merely of proof-of-principle nature and visions, but they are compelling enough to drive the field forward. We hope to engage the interest of clinicians, basic scientists, engineers, translational researchers and applied scientists from many areas, and particularly to attract young scientists and new entrants into the field. In doing so, we hope to convince the MR imaging and spectroscopy communities to throw their weight into the task of solving technical problems and conceiving new clinical applications. UHF MR has a staggering number of potential uses in neuroscience, neurology, radiology, cardiology, internal medicine, oncology, nephrology, ophthalmology and other related clinical fields. As they are developed, we will push the boundaries of MR physics, biomedical engineering and biomedical sciences in many other ways.Another reason this special issue is timely is because physicists, engineers and pioneers from related disciplines have already taken an even further step into the future, in their minds, with something they are calling Extreme Field MR (EF-MR). This envisions human MR at 20 T [37,38], and it is an important leap of the imagination because it aims to fill a crucial "resolution gap" in our understanding of human biology [39,40]. While discoveries are pouring in on the molecular and cellular level every day, it is The development of ultrahigh-field magnetic resonance (UHF-MR) is moving forward at an amazing speed that is breaking through technical barriers almost as fast as they appear. UHF-MR has become an engine for innovation in experimental and clinical research [1][2][3][4][5][6][7][8][9][10][11]. With more than 35,000 MR examinations already performed at 7.0 Tesla, the reasons for moving UHF-MR into clinical applications are more compelling than ever. The value of high-field MR has already proven itself many times over at lower field strengths; now 7.0 T has opened a window on tissues, organs and (patho)physiological processes that have been largely inaccessible in the past. Images from these instruments have revealed new aspects of the anatomy, functions and physio-metabolic characteristics of the brain, heart, joints, kidneys, liver, eye and other organs/tissues, at an unparalleled quality. The number 35,000 sounds large, but in fact we have barely cracked open the door and have yet to truly assess what lies on...

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Emerging methods and applications of ultra-high field MR spectroscopic imaging in the human brain

Hangel

Hečková

Lazen

et al. 2022

Analytical Biochemistry

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Evidencing different neurochemical profiles between thalamic nuclei using high resolution 2D-PRESS semi-LASER 1H-MRSI at 7 T

Abstract: For the first time, using high resolution 2D-PRESS semi-LASER (1)H-MRSI acquired at 7 T, we demonstrated that the neurochemical profiles were different between thalamic nuclei, and that these profiles were dependent on the brain hemisphere.

Cited by 6 publications

References 45 publications

Automatic segmentation of deep grey nuclei using a high‐resolution 7T magnetic resonance imaging atlas—Quantification of T1 values in healthy volunteers

Automatic segmentation of deep grey nuclei using a high‐resolution 7T magnetic resonance imaging atlas—Quantification of T1 values in healthy volunteers

From ultrahigh to extreme field magnetic resonance: where physics, biology and medicine meet

Emerging methods and applications of ultra-high field MR spectroscopic imaging in the human brain

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