Evidências Dos Efeitos Neurotóxicos Por Exposição Ao Agrotóxico: Uma Revisão Integrativa / Evidence of Neurotoxic Effects by Exposure to Pesticide

Santos, Nathália Freitas Dos; Contrera, Luciana; Teston, Élen Ferraz; Kawakame, Patrícia Moita Garcia; Reis, Laura Elis Aguero; Amarilha, Kelven Jones de Oliveira

doi:10.34117/bjdv6n12-640

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…Numerous in vivo studies (reviewed by Disner et al [ 77 ]) have recursively proven that exposure to pesticides, either isolated or in combination [ 78 ], affect human health due to their actions as carcinogens [ 79 , 80 , 81 , 82 , 83 , 84 ], neurotoxicants [ 85 , 86 , 87 , 88 ], endocrine disruptors, developmental toxicants [ 89 , 90 , 91 , 92 ], and metabolic toxicants [ 93 , 94 ].…”

Section: Resultsmentioning

confidence: 99%

Impact of Pesticides on Human Health in the Last Six Years in Brazil

Lopes-Ferreira

Maleski

Balan-Lima

et al. 2022

IJERPH

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Every year, Brazil intensifies its activity in agriculture and, as a result, it has become one of the biggest consumers of pesticides in the world. The high rate of these substances raises environmental and human health concerns. Therefore, we collected papers from PubMed, Scopus, Scielo, and Web of Science databases, from 2015 to 2021. After a blind selection using the software Rayyan QCRI by two authors, 51 studies were included. Researchers from the South and the Southeast Brazilian regions contributed to most publications, from areas that concentrate agricultural commodity complexes. Among the pesticides described in the studies, insecticides, herbicides, and fungicides were the most frequent. The articles reported multiple toxic effects, particularly in rural workers. The results obtained can be used to direct policies to reduce the use of pesticides, and to protect the health of the population.

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Section: Resultsmentioning

confidence: 99%

Impact of Pesticides on Human Health in the Last Six Years in Brazil

Lopes-Ferreira

Maleski

Balan-Lima

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…Research to date has demonstrated that the toxic effects of pesticides are manifested in different ways, from acute and sublethal effects to severe intoxication by chronic exposure to low doses. Evidence from several studies (reviewed by [ 30 , 31 ]) supports carcinogenicity [ 32 , 33 , 34 ], neurotoxicity [ 35 , 36 , 37 , 38 , 39 ], endocrine and developmental disruption [ 40 , 41 , 42 , 43 , 44 , 45 ] and metabolic toxicity [ 46 , 47 , 48 ] as underlying pathogenic mechanisms of pesticides.…”

Section: Pesticides Disrupt the Integrity Of The Epithelial Barriersmentioning

confidence: 99%

Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases

Lima

Falcão

Rosa

et al. 2022

IJMS

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The environmental and occupational risk we confront from agricultural chemicals increases as their presence in natural habitats rises to hazardous levels, building a major part of the exposome. This is of particular concern in low- and middle-income countries, such as Brazil, known as a leading producer of agricultural commodities and consumer of pesticides. As long as public policies continue to encourage the indiscriminate use of pesticides and governments continue to support this strategy instead of endorsing sustainable agricultural alternatives, the environmental burden that damages epithelial barriers will continue to grow. Chronic exposure to environmental contaminants in early life can affect crucial barrier tissue, such as skin epithelium, airways, and intestine, causing increased permeability, leaking, dysbiosis, and inflammation, with serious implications for metabolism and homeostasis. This vicious cycle of exposure to environmental factors and the consequent damage to the epithelial barrier has been associated with an increase in immune-mediated chronic inflammatory diseases. Understanding how the harmful effects of pesticides on the epithelial barrier impact cellular interactions mediated by endogenous sensors that coordinate a successful immune system represents a crucial challenge. In line with the epithelial barrier hypothesis, this narrative review reports the available evidence on the effects of pesticides on epithelial barrier integrity, dysbiosis, AhR signaling, and the consequent development of immune-mediated inflammatory diseases.

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Evidências Dos Efeitos Neurotóxicos Por Exposição Ao Agrotóxico: Uma Revisão Integrativa / Evidence of Neurotoxic Effects by Exposure to Pesticide

Cited by 2 publications

References 3 publications

Impact of Pesticides on Human Health in the Last Six Years in Brazil

Impact of Pesticides on Human Health in the Last Six Years in Brazil

Pesticides and Their Impairing Effects on Epithelial Barrier Integrity, Dysbiosis, Disruption of the AhR Signaling Pathway and Development of Immune-Mediated Inflammatory Diseases

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