Evidences for correlation between the reduced VCAM-1 expression and hyaluronan synthesis during cellular senescence of human mesenchymal stem cells

Jung, Eun Mi; Kwon, Ohsuk; Kwon, Ki‐Sun; Cho, Yee Sook; Rhee, Shin Hyung; Kim, Jung Min; Oh, Doo-Byoung

doi:10.1016/j.bbrc.2010.12.003

Cited by 55 publications

(41 citation statements)

References 16 publications

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“…We have previously shown that both plasma and CSF levels of sICAM-1 and sVCAM-1 are increased in AD and DLB patients (included in the Malmö Alzheimer Study) compared to healthy elders (6) and others have shown that ICAM-1 is both present in neuritic plaques and increased in cerebrovascular endothelium of AD patients (33). Furthermore, previous studies have shown that production of sICAM-1 and sVCAM-1 are influenced by HA (57,58). When investigating the correlation between CSF HA levels and sICAM-1 and sVCAM-1 CSF levels we found that only females in the control and AD, ADv groups showed a correlation between HA and sICAM-1 and sVCAM-1, whereas only males in the DLB group showed correlations between HA and the mentioned adhesion molecules.…”

Section: Discussionmentioning

confidence: 95%

Gender-Dependent Levels of Hyaluronic Acid in Cerebrospinal Fluid of Patients with Neurodegenerative Dementia

Nielsen¹,

Palmqvist²,

Minthon³

et al. 2012

CAR

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Numerous reports over the years have described neuroinflammatory events and vascular changes in neurodegenerative diseases such as Alzheimer´s disease (AD) and dementia with Lewy bodies (DLB). Interestingly, recent reports from other research areas suggest that inflammatory and vascular processes are influenced by gender. These findings are intriguing from the perspective that women show a higher incidence of AD and warrant investigations on how gender influences various processes in neurodegenerative dementia. In the current study we measured the cerebrospinal fluid (CSF) and plasma concentrations of hyaluroinic acid (HA), an adhesionmolecule known to regulate both vascular and inflammatory processes, in AD and DLB patients as well as in healthy elders. Our analysis showed that male AD and DLB patients had almost double the amount of HA compared to female patients whereas no gender differences were observed in the controls. Furthermore, we found that CSF levels of HA in foremost female AD patients correlated with various AD related biomarkers. Correlations between HA levels and markers of inflammation and vascular changes were only detected in female AD patients but in both male and female DLB patients. We conclude that HA may be linked to several pathological events present in AD, as reflected in CSF protein concentrations. The HA profile in CSF, but not in plasma, and associations to other markers appear to be genderdependent which should be taken into account in clinical examinations and future biomarker studies.

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Section: Discussionmentioning

confidence: 95%

Gender-Dependent Levels of Hyaluronic Acid in Cerebrospinal Fluid of Patients with Neurodegenerative Dementia

Nielsen¹,

Palmqvist²,

Minthon³

et al. 2012

CAR

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“…Targeting HAS2 by an miRNA caused cellular senescence, suggesting a role of HA in skin aging [137]. On the other side, HA concentrations in extracellular and pericellular matrices was greatly reduced in senescent mesenchymal stem cells, mainly due to the decreased expression of HA synthases [138]. An HA-based compound inhibited fibroblast senescence induced by oxidative stress in vitro [139].…”

Section: Ha In Biological Processesmentioning

confidence: 99%

Hyaluronan as a therapeutic target in human diseases

Liang

Jiang

Noble

2016

Advanced Drug Delivery Reviews

179

117

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Accumulation and turnover of extracellular matrix is a hallmark of tissue injury, repair and remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix and plays an important role in regulating tissue injury and repair, and controlling disease outcomes. The function of hyaluronan depends on its size, location, and interactions with binding partners. While fragmented hyaluronan stimulates the expression of an array of genes by a variety of cell types regulating inflammatory responses and tissue repair, cell surface hyaluronan provides protection against tissue damage from the environment and promotes regeneration and repair. The interactions of hyaluronan and its binding proteins participate in the pathogenesis of many human diseases. Thus, targeting hyaluronan and its interactions with cells and proteins may provide new approaches to developing therapeutics for inflammatory and fibrosing diseases. This review focuses on the role of hyaluronan in biological and pathological processes, and as a potential therapeutic target in human diseases.

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“…As a possible cause of this decreased expression, contaminating fibroblasts are found in bone marrow and express low levels of MSC markers; another possibility is that the expression level of MSC markers decreases during the long-term culture of human MSCs [23][24][25]. This decrease in expression indicates that long-term culturing induces changes in the expression of these markers; therefore, cmBMDCs may undergo a similar change in their expression pattern.…”

mentioning

confidence: 99%

Characterization of common marmoset (Callithrix jacchus) bone marrow-derived mesenchymal stem cells

Kanda

Sotomaru

Nobukiyo³

et al. 2014

Folia Histochem Cytobiol.

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Abstract:Mesenchymal stem cells (MSCs) could be useful for regenerative medicine because they can be harvested easily from the bone marrow of living donors and the cells can be differentiated into adipogenic, osteogenic, and chondrogenic lineages in vitro. To apply MSCs for the medical treatment of human diseases as regenerative medicine, detailed experimental characterization of the cells is required. Recently, a New World primate, the common marmoset (Callithrix jacchus), has been widely used as a new human disease model because of its ease of handling and breeding. Although common marmoset MSCs have been established and will be used in preclinical studies of regenerative medicine, the characteristics of these cells remain unclear. Aiming to characterize common marmoset MSCs further, we harvested common marmoset bone marrow-derived cells (cmBMDCs) from the femurs of newborn males. We revealed that the morphology of the cells was similar to common marmoset fibroblasts, and extracellular matrix components, such as gelatin and fibronectin, were effective for their proliferation and formation of colony-forming unit fibroblasts. Furthermore, we were able to differentiate cmBMDCs into adipocytes, osteocytes, and chondrocytes in vitro, and they expressed the MSC markers CD44, CD73, CD90, and CD105, but their expression decreased with increasing passage number. The data demonstrate that cmBMDCs exhibit characteristics of MSCs and thus it would be beneficial to use these cells in preclinical studies.

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Evidences for correlation between the reduced VCAM-1 expression and hyaluronan synthesis during cellular senescence of human mesenchymal stem cells

Cited by 55 publications

References 16 publications

Gender-Dependent Levels of Hyaluronic Acid in Cerebrospinal Fluid of Patients with Neurodegenerative Dementia

Gender-Dependent Levels of Hyaluronic Acid in Cerebrospinal Fluid of Patients with Neurodegenerative Dementia

Hyaluronan as a therapeutic target in human diseases

Characterization of common marmoset (Callithrix jacchus) bone marrow-derived mesenchymal stem cells

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