Evidence update for the treatment of anaphylaxis

Dodd, Amy; Hughes, Anna; Sargant, N; Whyte, Andy; Soar, Jasmeet; Turner, Paul J.

doi:10.1016/j.resuscitation.2021.04.010

Cited by 58 publications

(83 citation statements)

References 75 publications

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“…The patient's prompt discharge following resolution of the airway narrowing on x-ray after a single dose of epinephrine is consistent with the 2021 United Kingdom Resuscitation Council guidelines for anaphylaxis [6]. The patient was followed up by telephone 4 months later and continued to be in good health, with no further allergic reactions or anaphylactic episodes.…”

Section: Figure 3: Lateral View Radiograph Of Soft Tissue Of Neck 2 Hours and 37 Minutes Later Demonstrating Much-improved Airway (Arrow)supporting

confidence: 65%

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Anaphylaxis Presenting as Uvulitis

Nguyen¹,

Stead²,

Ortiz³

et al. 2021

Cureus

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The authors present a case of a young man who woke up with uvular swelling resulting in a severely narrowed airway. He had ingested peanut butter the prior night but was unaware of any allergies. He was treated with epinephrine, diphenhydramine, and methylprednisolone which resulted in resolution of the airway compromise. The authors discuss the mechanism of anaphylaxis and the emergency management of this life-threatening condition.

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Section: Figure 3: Lateral View Radiograph Of Soft Tissue Of Neck 2 Hours and 37 Minutes Later Demonstrating Much-improved Airway (Arrow)supporting

confidence: 65%

“…Epinephrine is the first line of treatment for anaphylaxis. Failing to administer timely epinephrine can result in progression to biphasic anaphylaxis or death [ 6 ]. During an allergic reaction, vasodilating histamines increase vascular permeability, resulting in inflammation.…”

Section: Discussionmentioning

confidence: 99%

Anaphylaxis Presenting as Uvulitis

Nguyen¹,

Stead²,

Ortiz³

et al. 2021

Cureus

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“…Monitoring in relation to blood pressure was of importance; anaphylaxis in mastocytosis often presents predominantly with hypotension, often with flushing but without the urticaria and angioedema classically associated with an anaphylactic event. The clinic was equipped with appropriate medications to manage anaphylaxis were it to have occurred, according to the Resuscitation Council UK anaphylaxis guidelines 15…”

Section: Case Presentationmentioning

confidence: 99%

Dental management of a patient with systemic mastocytosis

Whyte

Heywood

2022

BMJ Case Rep

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Mastocytosis is a term encompassing a group of clinical disorders characterised by clonal proliferation of abnormal mast cells (MCs) in organ systems of the body. Mastocytosis can be systemic (with or without skin involvement) or cutaneous, and can affect organs including bone marrow, liver, spleen, lymph nodes and mucosal surfaces. Patients with systemic mastocytosis (SM) are susceptible to triggers that could cause activation of abnormal MCs, resulting in multiorgan dysfunction and life-threatening anaphylactic reactions. Mastocytosis has a number of ramifications for the dental management of a patient with the condition. Patients are at increased risk of complications due to a number of risk factors for MC activation present within the dental context, including stress, certain prescribed drugs, oral hygiene products and dental materials. This report presents the oral management of an adult with SM, discussing the implications of the condition within the context of the limited existing literature on the subject.

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“…Anaphylaxis is a severe and potentially life-threatening allergic reaction [ 1 ]. It is estimated that approximately one to four patients per 1000 emergency department visits occur due to anaphylaxis [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Anaphylactic shock following minor abdominal trauma as the initial presentation of Echinococcus cyst: a case report

et al. 2022

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Background Anaphylaxis is a potentially life-threatening condition caused by a variety of triggers. However, anaphylaxis following an abdominal trauma is an exceptionally rare condition and could be the first and only sign of hepatic hydatid cyst, especially when no obvious etiology is present. Here, we present such a rare case and discuss relevant diagnostic and management strategy in light of the literature. Case report This case report refers to a 17 year-old previously healthy girl admitted in our pediatric emergency department (ED) for syncope after a minor blunt abdominal trauma. She was hypotensive on admission and shortly after she developed urticaria and angioedema. She was diagnosed with anaphylaxis and treated immediately. Possible etiologies including drug or food ingestion, insect bite, and previous allergy/anaphylaxis history were excluded. After stabilization abdominal imaging was performed, which revealed a ruptured large hepatic hydatid cyst in the vicinity of biliary tree. Albendazole treatment was started and surgical resection was performed after clinical stabilization, which confirmed the cyst rupture into the biliary ducts. Patient recovered without complications after surgery and was discharged uneventfully. Conclusion This case report highlights that hydatid cyst rupture should be included in the differential diagnosis of anaphylaxis without obvious etiology, particularly in regions where hydatid disease is endemic. Ruptured hydatid cyst leading to anaphylaxis requires timely diagnosis, management and emergent intervention.

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Evidence update for the treatment of anaphylaxis

Cited by 58 publications

References 75 publications

Anaphylaxis Presenting as Uvulitis

Anaphylaxis Presenting as Uvulitis

Dental management of a patient with systemic mastocytosis

Anaphylactic shock following minor abdominal trauma as the initial presentation of Echinococcus cyst: a case report

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