Evidence that urinary excretion of thiouracil in adult bovine submitted to a cruciferous diet can give erroneous indications of the possible illegal use of thyrostats in meat production

Pinel, Gaud; Mathieu, Sophie; Cesbron, Nora; Maume, Daniel; Brabander, H.F. De; André, François; Bizec, Bruno Le

doi:10.1080/02652030600806370

Cited by 50 publications

(50 citation statements)

References 6 publications

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“…Evidence for the occurrence of thiouracil in urine of cattle fed on a cruciferous-based diet has been demonstrated (Pinel et al, 2006).…”

Section: (A) Dioxinsmentioning

confidence: 99%

Scientific Opinion on the public health hazards to be covered by inspection of meat (bovine animals)

2013

EFSA Journal

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A risk ranking process identified Salmonella spp. and pathogenic verocytotoxin-producing Escherichia coli (VTEC) as current high-priority biological hazards for meat inspection of bovine animals. As these hazards are not detected by traditional meat inspection, a meat safety assurance system for the farm-to-chilled carcass continuum using a risk-based approach was proposed. Key elements of the system are risk-categorisation of slaughter animals for high-priority biological hazards based on improved food chain information, as well as risk-categorisation of slaughterhouses according to their capability to control those hazards. Omission of palpation and incision during post-mortem inspection for animals subjected to routine slaughter may decrease spreading and cross-contamination with the high-priority biological hazards. For chemical hazards, dioxins and dioxin-like polychlorinated biphenyls were ranked as being of high potential concern; all other substances were SUMMARYFollowing a request from the European Commission, the EFSA Panel on Biological Hazards (BIOHAZ) was asked to deliver a Scientific Opinion on the public health hazards to be covered by inspection of meat from several animal species, with the contribution of the Panel on Contaminants in the Food Chain (CONTAM) and the Panel on Animal Health and Welfare (AHAW). Briefly, the main risks to public health that should be addressed by the meat inspection system were identified and ranked; the strengths and weaknesses of the current meat inspection system were evaluated; recommendations were made for inspection methods addressing hazards not covered by the current meat inspection system; and recommendations for adaptations of inspection methods and/or frequencies of inspection that provide an equivalent level of protection were made. In addition, the implications for animal health and animal welfare of any proposed changes to current inspection methods were assessed. This opinion covers the inspection of meat from bovine animals.The Terms of Reference from the European Commission requested two opinions, one covering bovine animals under six weeks old and the other covering bovine animals over six weeks old. It was determined that within a true risk-based meat inspection concept, it is not necessary to design and apply a separate meat inspection system for individual bovine species or farming systems or animal age categories. Rather, a universal meat inspection framework can be designed and applied that would allow risk categorisation of animals based on individual farm-related food chain information (FCI), which also includes farming system and animal age category components. Furthermore, the available data from the National Residue Control Programmes (NRCPs) do not readily discriminate between the two age groups. Therefore, the assessment did not differentiate between these two age groups in terms of biological hazards, chemical residues and contaminants, and subsequently a single opinion is provided.Decision trees were developed and used for pr...

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“…Evidence for the occurrence of thiouracil in urine of cattle fed on a cruciferous-based diet has been demonstrated (Pinel et al, 2006).…”

Section: (A) Dioxinsmentioning

confidence: 99%

Scientific Opinion on the public health hazards to be covered by inspection of meat (bovine animals)

2013

EFSA Journal

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“…Pinel et al (2006) demonstrated that urinary excretion of thiouracil in adult bovines fed with cruciferous plants can give erroneous indications of the possible illegal use of thyrostats in meat production animals. …”

Section: Eu Overall Assessmentmentioning

confidence: 99%

Report for 2015 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products

2017

EFSA Supporting Publications

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The report summarises the monitoring data collected in 2015 on the presence of residues of veterinary medicinal products and certain substances in live animals and animal products in the European Union. A total of 729,881 samples were reported to the European Commission by the 28 EU Member States. They consisted of 411,677 targeted samples and 19,257 suspect samples reported under Council Directive 96/23/EC, and of 3,768 samples collected at import and 295,179 samples collected in the framework of programmes developed under the national legislation. The majority of Member States fulfilled the minimum requirements for sampling frequency laid down in Council Directive 96/23/EC and in Commission Decision 97/747/EC. Overall in 2015, the percentage of noncompliant targeted samples (0.34%) was comparable to the previous 8 years (0.25%-0.37%). In 2015, the frequency of non-compliant samples was higher for resorcylic acid lactones, chemical elements (mainly metals) and mycotoxins, compared to previous years, although lower than those reported in 2014. Higher frequencies of non-compliant samples were noted for antithyroid agents, compared to previous years, except for 2013 when the highest frequency was reported. The frequency of non-compliant samples for 'other pharmacologically active substances' was lower compared to previous years, except for 2011 when the lowest frequency was reported. For the other substance groups, there were no notable variations over the 9 year period. This analysis should be regarded as having a certain degree of uncertainty, as it is based on partially aggregated data and the sampling plans and the spectrum of substances analysed are not necessarily the same every year.

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“…Residues of thiouracil resulted most probably from feeding diets rich in cruciferous plants. Pinel et al (2006) demonstrated that urinary excretion of thiouracil in adult bovines fed with cruciferous plants can give erroneous indications of the possible illegal use of thyrostats in meat production animals.…”

Section: Eu Overall Assessmentmentioning

confidence: 99%

“…Maximum levels for contaminants are laid down in Commission Regulation (EC) No 1881/2006 15 For contaminants where no EU maximum levels had been fixed at the time when data included in this report were collected, national tolerance levels were applied.  Identification of main substances contributing to non-compliant results within a group.…”

Section: Introductionmentioning

confidence: 99%

Report for 2013 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products

2015

EFSA Supporting Publications

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Evidence that urinary excretion of thiouracil in adult bovine submitted to a cruciferous diet can give erroneous indications of the possible illegal use of thyrostats in meat production

Cited by 50 publications

References 6 publications

Scientific Opinion on the public health hazards to be covered by inspection of meat (bovine animals)

Scientific Opinion on the public health hazards to be covered by inspection of meat (bovine animals)

Report for 2015 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products

Report for 2013 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products

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