“…From this TRPC family, TRPC1, TRPC3, TRPC4, TRPC5, and TRPC6 were shown to be expressed and functional in hPK, and all of them were shown to be involved in SOCE (27,(29)(30)(31). Interestingly, although the short-term transient increase in [Ca 2+ ] i is mostly attributed to be proproliferative, for two of them, TRPC1 and TRPC4, which where shown to be SOCs, a role in SOCE and keratinocyte differentiation was shown (27,29,32,33). Among all of them, a member of the vanilloid family of TRP channels, TRPV6, has been shown to be expressed and to positively correlate with the calcium gradient (a stepwise increase in both intra-and extracellular calcium from stratum basale to stratum corneum) (34-36) and differentiation in the skin, providing a massive calcium entry into keratinocytes that is necessary to induce differentiation (37,38).…”