“…Darier's disease -TRPC1 perspective TRPC1, which is typically activated by ER store depletion, has been reported to be a critical component of SOCs in many cell types including endothelial, neuronal, smooth muscle and salivary gland cells, platelets, and keratinocytes [30,35,36,38,44,45]. Its interactions with the newly identified SOCE components, STIM1 and ORAI1, as a dynamic complex further amplify the physiological significance of TRPC1 as a SOC [41,46,47].…”