1986
DOI: 10.1016/0049-3848(86)91701-9
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Evidence that the rat is not an appropriate model to study the role of prostaglandins in normal or abnormal platelet aggregation

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1986
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Cited by 19 publications
(4 citation statements)
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“…In contrast, the three cyclo-oxygenase inhibitors were completely ineffective. These results are in agreement with previous reports indicating that ASA is inactive in vitro and in vivo (3,29,30,31). This is not surprising because ADP-induced aggregation of rat platelets produces only a single aggregation wave, without production of TXA2, whatever the calcium concentration of the medium (1).…”
Section: Discussionsupporting
confidence: 94%
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“…In contrast, the three cyclo-oxygenase inhibitors were completely ineffective. These results are in agreement with previous reports indicating that ASA is inactive in vitro and in vivo (3,29,30,31). This is not surprising because ADP-induced aggregation of rat platelets produces only a single aggregation wave, without production of TXA2, whatever the calcium concentration of the medium (1).…”
Section: Discussionsupporting
confidence: 94%
“…It is tempting to attribute this inhibition to blockade of endoperoxide or TXA2 synthesis. However, these substances (3,4), like their precursor arachidonic acid (2, 3), do not aggregate rat platelets at non-lytic concentrations. Nevertheless, it is possible that TXA2 formed upon collagen stimulation could act synergistically with released ADP (2), so that cyclo-oxygenase inhibition would block this potentiation.…”
Section: Discussionmentioning
confidence: 97%
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“…Activation of platelets of these rat strains has been examined by different authors with inconsistent results regarding hypo-or hyperaggregability. [10][11][12][13][14][15][16] Because most of these results have been obtained from in vitro experiments, different methodology (washed platelet or platelets in plasma, different anticoagulants) may at least partially explain this discrepancy.…”
mentioning
confidence: 99%