Evidence that the effects of arginine-8-vasopressin (AVP) on pituitary corticotropin (ACTH) release are mediated by a novel type of receptor

Antoni, Ferenc András; Holmes, Megan C.; Makara, Gábor B.; Kárteszi, M.; László, Ferenc

doi:10.1016/0196-9781(84)90080-9

Cited by 101 publications

(43 citation statements)

References 25 publications

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“…The reason for this variation in affinity of [d(CH2)5Tyr(Me)]AVP is not known, but the possibility of further heterogeneity of vasopressin V1 receptors exists (Vanner et al, 1990). It has been found that the vasopressin VI receptor in the pituitary gland is resistant to antagonism by [d(CH2)5Tyr(Me)2]AVP, (Antoni et al, 1984), and this subtype of vasopressin receptor has been designed as Vib (Jard et al,1986) or V3 (Baertschi & Friedli, 1985 (Katusic et al, 1984;Vanner et al, 1990;Thibonnier et al, 1993), suggesting the presence of contraction-mediating V,-vasopressin receptors in the preparations studied. In contrast, the -log KB values of…”

Section: Discussionmentioning

confidence: 99%

Characterization of arginine vasopressin actions in human uterine artery: lack of role of the vascular endothelium

Jovanović

Grbović

Žikić

et al. 1995

British J Pharmacology

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Section: Discussionmentioning

confidence: 99%

Characterization of arginine vasopressin actions in human uterine artery: lack of role of the vascular endothelium

Jovanović

Grbović

Žikić

et al. 1995

British J Pharmacology

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“…During an acute stress response, the HPA-axis is activated by the hypothalamus quickly releasing corticotropin-releasing hormone (CRH; Ma et al, 1997), which acts to stimulate the pituitary gland to release adrenocorticotropic hormone (ACTH; Antoni et al, 1984). ACTH influences the adrenal glands, releasing adrenocorticoids (i.e.…”

Section: Introductionmentioning

confidence: 99%

Variation in adrenal and thyroid hormones with life-history stage in juvenile northern elephant seals (Mirounga angustirostris)

Jelincic

Tift

Houser

et al. 2017

General and Comparative Endocrinology

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“…While arginine vasopressin (AVP) and angiotensin I1 stimulate ACTH release to a lesser extent, they can both act synergistically with CRH to increase corticotrope responses (2-6). It has since been shown that CRH and AVP exert their actions through different receptors on the corticotrope surface (1,(7)(8)(9)(10). However, the mechanism mediating their synergistic effect remains uncertain.…”

mentioning

confidence: 99%

Reverse Haemolytic Plaque Assay Study of Corticotropin‐Releasing Hormone and Arginine Vasopressin Interaction in Ovine Corticotropes

Madsen

Chan

Falconer

et al. 1991

J Neuroendocrinology

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Corticotropin-releasing hormone and arginine vasopressin are known to interact in stimulating secretion of adrenocorticotropinrelated peptides from corticotropes. However, the mechanism mediating this interaction is uncertain. Recently, evidence has been provided using a reverse haemolytic plaque assay that in rat pituitary cells, arginine vasopressin potentiates the effects of corticotropin-releasing hormone by increasing the percentage of target cells that secrete adrenocorticotropin. To determine whether a similar mechanism also operates in the sheep corticotrope, which is reportedly more sensitive to arginine vasopressin than that of the rat, a reverse haemolytic plaque assay for /%endorphin secretion was used to study the response of ovine corticotropes to stimulation by increasing doses of corticotropin-releasing hormone or arginine vasopressin (0.1 nM to 10.0 nM) alone or in combination.In the reverse haemolytic plaque assay, P-endorphin antiserum at 1 5 0 and complement at 1:lO were found to be optimal dilutions for plaque formation. A concentration-dependent response curve to corticotropin-releasing hormone was obtained with a significant increase in plaque area from basal to reach maximal levels at 1.0 nM. Arginine vasopressin also stimulated an increase in plaque area, however, plaques formed were significantly smaller than those caused by corticotropin-releasing hormone. Since in the reverse haemolytic plaque assay, plaque area is related to the amount of hormone secreted by the cell, results demonstrate that although corticotropin-releasing hormone and arginine vasopressin both stimulate b-endorphin secretion from ovine corticotropes, corticotropin-releasing hormone is a more potent secretagogue than arginine vasopressin in that it causes the formation of significantly larger plaques.The addition of arginine vasopressin to low concentrations of corticotropin-releasing hormone caused plaque areas to reach maximal levels at 0.1 nM whereas these levels were only attained at 1.0 nM when corticotropin-releasing hormone was used alone. Therefore, arginine vasopressin interacts with corticotropin-releasing hormone to increase corticotrope responses by increasing their secretory response to corticotropin-releasing hormone. These data are consistent with previous work suggesting that arginine vasopressin increases the expression of corticotropin-releasing hormone receptors on the corticotrope cell surface. However, no significant increase in the percentage of plaque-forming cells was seen with either corticotropin-releasing hormone or arginine vasopressin alone or in combination implying that there was no recruitment of previously non-secreting cells.It is now well established that secretion of proopiomelanocortin fragments, such as adrenocorticotropin (ACTH) and j-endorphin (j-EP), from corticotropes of the anterior pituitary in mammals is regulated by a number of releasing factors secreted from the hypothalamus (1). In the rat, the 41 amino-acid peptide corticotropin-releasing hormone (CRH) is cons...

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Evidence that the effects of arginine-8-vasopressin (AVP) on pituitary corticotropin (ACTH) release are mediated by a novel type of receptor

Cited by 101 publications

References 25 publications

Characterization of arginine vasopressin actions in human uterine artery: lack of role of the vascular endothelium

Characterization of arginine vasopressin actions in human uterine artery: lack of role of the vascular endothelium

Variation in adrenal and thyroid hormones with life-history stage in juvenile northern elephant seals (Mirounga angustirostris)

Reverse Haemolytic Plaque Assay Study of Corticotropin‐Releasing Hormone and Arginine Vasopressin Interaction in Ovine Corticotropes

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