Evidence That Termination of the Estradiol-Induced Luteinizing Hormone Surge in Women Is Regulated by Ovarian Factors

Dafopoulos, Konstantinos; Mademtzis, I.; Vanakara, Polyxeni; Kallitsaris, A.; Stamatiou, Georgios; Kotsovassilis, Constantin; Messinis, Ioannis E.

doi:10.1210/jc.2005-1656

Cited by 19 publications

(18 citation statements)

References 24 publications

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“…In cycle 2, the first E 2 patch was applied after the end of the operation. The dose of E 2 was chosen on the basis of previously published data (20,21) to induce serum concentrations of E 2 similar to those seen during the preovulatory period of the normal menstrual cycle. Blood samples were taken from all women in both cycles every morning (9:00 a.m.), after overnight fasting, from cycle days 3 to 9.…”

Section: Materials and Methods Subjectsmentioning

confidence: 99%

Effect of ovarian hormones on serum adiponectin and resistin concentrations

Chalvatzas

Dafopoulos

Kosmas

et al. 2009

Fertility and Sterility

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Section: Materials and Methods Subjectsmentioning

confidence: 99%

Effect of ovarian hormones on serum adiponectin and resistin concentrations

Chalvatzas

Dafopoulos

Kosmas

et al. 2009

Fertility and Sterility

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“…It is tempting to speculate that in mammalian species in which progesterone has been shown to terminate the GnRH/LH surge [142,143] it may arrest GnRH release by promoting the Sema7A-mediated engulfment of GnRH nerve terminals by tanycytic end feet. …”

Section: Semaphorins and Neuroglial Plasticity In The Adult Hypothalamentioning

confidence: 99%

Shaping the Reproductive System: Role of Semaphorins in Gonadotropin-Releasing Hormone Development and Function

Giacobini¹

2015

Neuroendocrinology

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The semaphorin proteins, which contribute to the morphogenesis and homeostasis of a wide range of systems, are among the best-studied families of guidance cues. Much recent research has focused on the role of semaphorins in the development and adult activity of hormone systems and, reciprocally, how circulating reproductive hormones regulate their expression and function. Specifically, several reports have focused on the molecular mechanisms underlying the effects of semaphorins on the migration, survival and structural and functional plasticity of neurons that secrete gonadotropin-releasing hormone (GnRH), essential for the acquisition and maintenance of reproductive competence in mammals. Alterations in the development of this neuroendocrine system lead to anomalous or absent GnRH secretion, resulting in heterogeneous reproductive disorders such as congenital hypogonadotropic hypogonadism (CHH) or other conditions characterized by infertility or subfertility. This review summarizes current knowledge of the role of semaphorins and their receptors on the development, differentiation and plasticity of the GnRH system. In addition, the involvement of genetic deficits in semaphorin signaling in some forms of CHH in humans is discussed.

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“…Therefore, it is proposed that progest-estrogenic mechanisms involving the progesterone receptors participate in the estradiol positive feedback mechanism, and thus regulating the LH surge onset [12]. Ovarian factors rather than exhaustion of pituitary reserves are suggested to be important for termination of the endogenous LH surge during the normal menstrual cycle [14].…”

Section: Positive Feedback Effect Of Estrogen Before Ovulation-the Prmentioning

confidence: 99%

Physiological Positive Feedback Mechanisms

Abdel-Sater¹,

Arabia²,

Ahmed³

et al. 2011

Am. J. Biomed. Sci.

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In positive feedback mechanisms, the response to a stimulus does not stop or reverse it but instead keeps the sequence of events going up. At first glance, this would appear to be a counter to the principle of homeostasis, since a positive feedback loop has no obvious means of stopping. Not surprisingly, therefore, the positive feedback is less common in nature than the negative one. A positive feedback mechanism can be harmful, as in case of fever that causes metabolic changes pushing it to be higher. However, in some instances, the body uses this mechanism for its advantage. A good example of significant positive feedback is the childbirth. Ovulation, coagulation, platelet aggregation, inflammation and shock are other instances in which the positive feedback plays a valuable role.

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Evidence That Termination of the Estradiol-Induced Luteinizing Hormone Surge in Women Is Regulated by Ovarian Factors

Abstract: It is suggested that ovarian factors rather than exhaustion of pituitary reserves are important for termination of the endogenous LH surge during the normal menstrual cycle.

Cited by 19 publications

References 24 publications

Effect of ovarian hormones on serum adiponectin and resistin concentrations

Effect of ovarian hormones on serum adiponectin and resistin concentrations

Shaping the Reproductive System: Role of Semaphorins in Gonadotropin-Releasing Hormone Development and Function

Physiological Positive Feedback Mechanisms

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