Evidence that somatostatin inhibits proinsulin synthesis and insulin release by isolated pancreatic islets of the rat

Effect of Ca++and Somatostatin on Insulin Release in Humans

“…Furthermore, we would like to point out that the rebound increase in IRI values after SRIF infusion ended was greater when Cs ++ was added to infusion, whereas blood glucose values did not differ significantly. Since SRIF seems to inhibit both the glucose-stimulated proinsulin synthesis and the insulin release from pancreatic islets (Williams and Bauer 1980), it could be suggested that the increase in Ca ++ concentrations can overcome the inhibitory effects of SRIF on proinsulin synthesis. However, to our knowledge, no interaction between SRIF and Ca ++ upon proinsulin synthesis has been demonstrated.…”