Evidence That Psychotic Symptoms Are Prevalent in Disorders of Anxiety and Depression, Impacting on Illness Onset, Risk, and Severity--Implications for Diagnosis and Ultra-High Risk Research

Wigman, Johanna T. W.; Nierop, Martine van; Vollebergh, Wilma; Lieb, Roselind; Beesdo‐Baum, Katja; Wittchen, Hans‐Ulrich; Os, Jim van

doi:10.1093/schbul/sbr196

Cited by 343 publications

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“…Our finding that subclinical psychotic experiences have a negative impact on the clinical manifestation of depression, both in terms of severity and of development over time, concurs with earlier work in the general population (Olfson et al 2002;van Rossum et al 2011;Wigman et al 2012) as well as in a clinical sample (Perlis et al 2011). In the latter, it was shown that depressed individuals with psychotic experiences responded less well to four consecutive pharmacological interventions.…”

Section: Discussionsupporting

confidence: 91%

“…Symptoms of psychosis (Hanssen et al 2003;Varghese et al 2011;Kelleher et al 2012b;Wigman et al 2012) and bipolar disorder (Angst et al 2010;Nusslock & Frank, 2011), at clinical and subclincal levels of expression, commonly occur in the context of major depressive disorder (MDD). This reflects overlap between affective and psychotic disorders in genetic ) and environmental risk factors (Weiser et al 2005), as well as in underlying endophenotypes, for example (neuro)cognitive, social and emotional dysfunctions (Weiser et al 2005;Hill et al 2009;Simonsen et al 2011).…”

Section: Introductionmentioning

confidence: 99%

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Subclinical psychotic experiences and bipolar spectrum features in depression: association with outcome of psychotherapy

Wigman

Abidi

et al. 2013

Psychol. Med.

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Background. Subthreshold psychotic and bipolar experiences are common in major depressive disorder (MDD). However, it is unknown if effectiveness of psychotherapy is altered in depressed patients who display such features compared with those without. The current paper aimed to investigate the impact of the co-presence of subclinical psychotic experiences and subclinical bipolar symptoms on the effectiveness of psychological treatment, alone or in combination with pharmacotherapy.Method. In a naturalistic study, patients with MDD (n = 116) received psychological treatment (cognitive behavioural therapy or interpersonal psychotherapy) alone or in combination with pharmacotherapy. Depression and functioning were assessed six times over 2 years. Lifetime psychotic experiences and bipolar symptoms were assessed at the second time point.Results. Subclinical psychotic experiences predicted more depression over time (β = 0.20, p < 0.002), non-remission [odds ratio (OR) 7.51, p < 0.016] and relapse (OR 3.85, p < 0.034). Subthreshold bipolar symptoms predicted relapse (OR 1.16, p < 0.037).Conclusions. In general, subclinical psychotic experiences have a negative impact on the course and outcome of psychotherapy in MDD. Effects of subclinical bipolar experiences were less prominent.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Subclinical psychotic experiences and bipolar spectrum features in depression: association with outcome of psychotherapy

Wigman

Abidi

et al. 2013

Psychol. Med.

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“…However, more research on underlying mechanisms is 13 required. The results of the present study show that PE serve as an indicator of illness severity and poor outcome in persons with non-psychotic psychopathology, in line with previous research (Guloksuz et al, 2015;Kelleher et al, 2012b;Perlis et al, 2011;Wigman et al, 2012;Wigman et al, 2014). Therefore, assessment of PE in individuals with non-psychotic psychopathology should be incorporated both in clinical practice and in future research, as previously suggested (Kelleher et al, 2013), in order to identify individuals at risk of suicidal behaviour.…”

Section: Discussionsupporting

confidence: 89%

“…PE were identified as a risk factor for several mental health outcomes including both psychotic (Kaymaz et al, 2012;Linscott and van Os, 2013) and non-psychotic psychopathology (Kelleher et al, 2012b) and are associated with increased treatment use and need for care in general population samples (Murphy et al, 2012). Moreover, PE serve as an indicator of illness severity and poor outcome in persons with non-psychotic psychopathology (Guloksuz et al, 2015;Kelleher et al, 2012b;Perlis et al, 2011;Wigman et al, 2012;Wigman et al, 2014) A recent meta-analysis reported that general population individuals with PE had an increased risk of both suicidal thoughts (i.e. suicidal ideation or suicidal plans) and suicidal behaviour (i.e.…”

Section: Introductionmentioning

confidence: 99%

Psychotic experiences and incident suicidal ideation and behaviour: Disentangling the longitudinal associations from connected psychopathology

Honings

Drukker

Nierop

et al. 2016

Psychiatry Research

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Psychotic experiences and incident suicidal ideation and behaviour 2 ABSTRACT This study examines the longitudinal associations between psychotic experiences (PE) and incident suicidal ideation and behaviour in the general population, and to what degree the association may be confounded by nonpsychotic psychopathology. Data from three prospective, general population cohorts were combined into one dataset (n=15837) and analysed using logistic regression, controlling for continuous measures of depression, anxiety and mania symptoms. Analyses were conducted in the entire sample, and in subsamples stratified by presence or absence of mental disorders. The presence of PE at baseline increased the risk of incident suicidal ideation and behaviour. However, adjustment for dimensional measures of psychopathology reduced effect sizes, although PE remained significantly associated with suicide attempts. Further examination of the associations revealed that PE were only associated with suicide attempts in individuals with at least one mental disorder.Similarly, in individuals without mental disorders, the risk of suicidal ideation increased as PE co-occurred with more symptom domains. The results of this study confirm that individuals with PE are at increased risk of suicidal ideation and behaviour. However, these associations are not specific, but reflect the increased risk of suicidal ideation in individuals with subthreshold multidimensional psychopathology and suicide attempts in individuals with co-occurring mental disorders.

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“…Much research has established that psychotic experiences have a higher prevalence in the general population than psychotic disorders [1][2][3][4]. A meta-analysis of all community studies of psychotic experiences in children and adolescents found a median population prevalence of 17% in children aged 9-12 years and 7.5% in those aged 13-18 years [5].…”

Section: Introductionmentioning

confidence: 99%

Relationship between the COMT-Val158Met and BDNF-Val66Met Polymorphisms, Childhood Trauma and Psychotic Experiences in an Adolescent General Population Sample

Ramsay¹,

Kelleher²,

Flannery³

et al. 2015

Holistic Perspectives on Trauma

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Objective: Psychotic experiences occur at a much greater prevalence in the population than psychotic disorders. There has been little research to date, however, on genetic risk for this extended psychosis phenotype. We examined whether COMT or BDNF genotypes were associated with psychotic experiences or interacted with childhood trauma in predicting psychotic experiences.Method: Psychiatric interviews and genotyping for COMT-Val158Met and BDNF-Val66Met were carried out on two population-based samples of 237 individuals aged 11-15 years. Logistic regression was used to examine for main effects by genotype and childhood trauma, controlling for important covariates. This was then compared to a model with a term for interaction between genotype and childhood trauma. Where a possible interaction was detected, this was further explored in stratified analyses. Results:While childhood trauma showed a borderline association with psychotic experiences, COMT-Val158Met and BDNF-Val66Met genotypes were not directly associated with psychotic experiences in the population. Testing for gene x environment interaction was borderline significant in the case of COMT-Val158Met with individuals with the COMT-Val158Met Val-Val genotype, who had been exposed to childhood trauma borderline significantly more likely to report psychotic experiences than those with Val-Met or Met-Met genotypes. There was no similar interaction by BDNF-Val66Met genotype. Conclusion:The COMT-Val158Met Val-Val genotype may be a genetic moderator of risk for psychotic experiences in individuals exposed to childhood traumatic experiences.

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Evidence That Psychotic Symptoms Are Prevalent in Disorders of Anxiety and Depression, Impacting on Illness Onset, Risk, and Severity--Implications for Diagnosis and Ultra-High Risk Research

Abstract: Copresence of psychotic symptomatology in disorders of anxiety and depression is common and a functionally and etiologically highly relevant feature, reinforcing the view that psychopathology is represented by a network or overlapping and reciprocally impacting dimensional liabilities.

Cited by 343 publications

References 50 publications

Subclinical psychotic experiences and bipolar spectrum features in depression: association with outcome of psychotherapy

Subclinical psychotic experiences and bipolar spectrum features in depression: association with outcome of psychotherapy

Psychotic experiences and incident suicidal ideation and behaviour: Disentangling the longitudinal associations from connected psychopathology

Relationship between the COMT-Val158Met and BDNF-Val66Met Polymorphisms, Childhood Trauma and Psychotic Experiences in an Adolescent General Population Sample

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