Evidence that male smoking affects the likelihood of a pregnancy following IVF treatment: application of the modified cumulative embryo score

Joesbury, Karen; Edirisinghe, W. Rohini; Phillips, Michael; Yovich, John L.

doi:10.1093/humrep/13.6.1506

Cited by 76 publications

(38 citation statements)

References 34 publications

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“…However, the lower peak E2 levels [21,22] and recruitment of fewer follicles and oocytes [7,13,15,21,23,24] in smokers that were reported in earlier studies were not observed in our population, in which milder and less vigorous stimulation was required.…”

Section: Discussioncontrasting

confidence: 78%

Influence of smoking on outcome of COH and IUI in subfertile couples

Farhi

Orvieto

2009

J Assist Reprod Genet

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Aim To evaluate the influence of smoking on the outcome of COH and IUI in subfertile couples. Patients and methods We reviewed the medical files of all consecutive women, age ≤35 years, attending our infertility clinics over an eigth-year period. Data on patient age, smoking habits, and variable related to infertility-treatment were collected from the files. Results A total of 2,318 cases were evaluated: 1,803 in nonsmoking patients (n=679) and 515 in smokers (n=206). The smokers used significantly more gonadotropin ampoules and gained a thinner endometrium on the day of hCG administration than the nonsmokers (p<0.016 for both). There were no between-groups differences in patient age, duration of gonadotropin stimulation, number of follicle >14 mm in diameter, or E2 levels on the day of hCG administration. Conclusion Smokers undergoing COH with IUI required a significantly higher gonadotropin dosage than nonsmokers in order to achieved a comparable pregnancy rate.

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Section: Discussioncontrasting

confidence: 78%

Influence of smoking on outcome of COH and IUI in subfertile couples

Farhi

Orvieto

2009

J Assist Reprod Genet

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“…(46) Moreover, gonadoreline decrease estrogen level which responsible for oxytocin receptor synthesis. (47) Additionally,chemical components of tobacco smoke may induce alkylation of DNA both in the oocyte and sperm which consequential to abnormal cytogenesis embryo (48,49,50) .…”

Section: Discussionmentioning

confidence: 99%

Gonadoreline Hormone Ameliorate the Deleterious Effects Of Nicotine On Uterine Performances During Pregnancy: Animal Model Study

Al-Kuraishy¹

2012

iosrphr

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This study was conducted on females rabbits of Newzealand white rabbit which was as an experimental model.The aim of this study is to elucidate the the effects of tobacco smoke exposures at doses 10 cigarettes and 20 cigaettes /day alone and in combination with of gonadoreline hormone subcutaneously ;which was exposed daily from first day of gestation until the time of delivery .then showing the effects of litter boy weight in correlation with pregnancy period.Results of this study showed that exposures to cigarette smoke alone in different doses reduced the litter body and pregnancy period consequentially(p<0.05).while exposures to cigarette smoke under effects of gonadoreline insignificantly affects these parameters(p>0.05).

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“…A reduced pregnancy rate was found in IVF cycles performed on couples with smoking male partners [46,144] . In experiments with male rats, exposure to cigarette smoke results in a secretory defi ciency of Leydig and Sertoli cells and an altered epididymal maturation [145] .…”

Section: Reproductive Consequences Of Smoking For Menmentioning

confidence: 97%

“…In general, the detrimental effect of smoking on IVF outcomes becomes more detectable in older women [34,46] . Cotinine and cadmium [47] are enriched in the follicular fl uid aspirated from smoking women but also, most worryingly, from passively exposed women at time of oocyte retrieval in IVF cycles, and concentrations correlate with the numbers of cigarettes smoked [48] .…”

Section: Smoking and Assisted Reproductionmentioning

confidence: 99%

Smoking and Reproduction

Prelog

2011

Cigarette Smoke Toxicity

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Evidence that male smoking affects the likelihood of a pregnancy following IVF treatment: application of the modified cumulative embryo score

Cited by 76 publications

References 34 publications

Influence of smoking on outcome of COH and IUI in subfertile couples

Influence of smoking on outcome of COH and IUI in subfertile couples

Gonadoreline Hormone Ameliorate the Deleterious Effects Of Nicotine On Uterine Performances During Pregnancy: Animal Model Study

Smoking and Reproduction

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