Evidence that eye‐movement profiles do not explain slow binocular rivalry rate in bipolar disorder: support for a perceptual endophenotype

Law, P. C. F.; Gurvich, Caroline; Ngo, Trung Thanh; Miller, Steven M.

doi:10.1111/bdi.12515

Cited by 3 publications

(3 citation statements)

References 82 publications

(201 reference statements)

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“…Because of that report, and potential EM-based alternative explanations, Phillip Law-who joined my lab as a PhD student in 2012-along with Ngo and I and colleagues including Caroline Gurvich, examined BR rates and EM profiles in healthy and BD subjects. In two articles, we reported no relationship between BR rates and EM profiles in either healthy or BD subjects, thus excluding EM explanations for slow BR in BD (Law et al, 2015;Law, Gurvich, Ngo, & Miller, 2017).…”

Section: The Experimentsmentioning

confidence: 84%

Fluctuations of consciousness, mood, and science: The interhemispheric switch and sticky switch models two decades on

Miller

2020

J of Comparative Neurology

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Science and medicine aim to identify verifiable and replicable truths. However, the paths to such truths are frequently characterized by swinging pendulums of opposing perspectives. This is especially so in human neuroscience and the brain-based clinical sciences, where the target of investigation is the most complex of all biological systems. This article overviews a set of interrelated neuroscientific and clinical hypotheses, models, experiments, and predictions with which I have been involved for the last two decades. Traversing visual neuroscience, consciousness science, genetics, chronobiology, and biological and clinical psychiatry, the work illustrates how developments in science and medicine can occur through a combination of synthesis, serendipity, and experimentation. The article also reflects on doing science with the inimitable John "Jack" Pettigrew, and outlines how Pettigrew and I conceived, proposed, tested, and developed two new scientific models-one on neural mechanisms of binocular rivalry, the other on the pathophysiology of bipolar disorder. I also provide an update on various aspects of our models and data, and describe lessons learned from Pettigrew on how perspectives in science exhibit their own fluctuations, ironically like the very phenomena on which we worked.

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Section: The Experimentsmentioning

confidence: 84%

Fluctuations of consciousness, mood, and science: The interhemispheric switch and sticky switch models two decades on

Miller

2020

J of Comparative Neurology

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“…Abnormalities in binocular rivalry have been found in several psychiatric disorders, such as anxiety (e.g., Jia et al, 2020; Nagamine et al, 2007), autism (e.g., Robertson et al, 2013; Skerswetat et al, 2022), bipolar disorder (e.g., Law et al, 2017; Pettigrew & Miller, 1998), schizophrenia (e.g., Sappenfield & Ripke, 1961; Xiao et al, 2018), and obsessive–compulsive disorder (Ye et al, 2019). Previous studies have also reported abnormalities of binocular rivalry in depression (Jia et al, 2015; Jia et al, 2020; Ye et al, 2019; but see also Miller et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

State‐dependent alterations of implicit emotional dominance during binocular rivalry in subthreshold depression

Qiu,

Luo,

Luo

et al. 2023

PsyCh Journal

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Binocular rivalry, a visual perception phenomenon where two or more percepts alternate every few seconds when distinct stimuli are presented to the two eyes, has been reported as a biomarker in several psychiatric disorders. It is unclear whether abnormalities of binocular rivalry in depression could occur when emotional rivaling stimuli are used, and if so, whether an emotional binocular rivalry test could provide a trait‐dependent or state‐dependent biomarker. In the current study, 34 individuals with subthreshold depression and 31 non‐depressed individuals performed a binocular rivalry task associated with implicit emotional processing. Participants were required to report their perceived orientations of the rival gratings in the foreground and to neglect emotional face stimuli in the background. The participants were retested after an approximately 4‐month time interval. Compared to the non‐depressed group, the subthreshold depression group showed significantly longer perceptual dominance durations of the grating with emotional faces as the background (i.e., implicit emotional dominance) at the initial assessment. However, the abnormality was not found at the follow‐up assessment. More importantly, we found smaller changes in depressive severity at the follow‐up assessment for individuals displaying longer emotional dominance at the initial assessment than for individuals with weaker emotional dominance. The current emotional binocular rivalry test may provide an objective, state‐dependent biomarker for distinguishing individuals with subthreshold depression from non‐depressed individuals.

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“…Abnormalities in binocular rivalry have been observed in several psychiatric disorders such as anxiety (e.g., [11,22]), autism (e.g., [23,24]), bipolar disorder (e.g., [25,26]), schizophrenia (e.g., [27,28]), and obsessive-compulsive disorder [29]. Several studies have also reported abnormalities of binocular rivalry in depression ( [11,29,30]; but [31]).…”

Section: Introductionmentioning

confidence: 99%

State-dependent alternations of implicit emotional dominance during binocular rivalry in subthreshold depression

Qiu

Luo

et al. 2022

Preprint

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Background: Binocular rivalry, a phenomenon that individuals often experience back-and-forth perceptual alterations when two distinct monocular stimuli are presented to each eye simultaneously, has been reported as a biomarker in several psychiatric disorders. It is unclear whether abnormalities of binocular rivalry in depression could exist when emotional rivaling stimuli are used, and if so, whether the emotional binocular rivalry test could provide a trait-dependent biomarker or a state-dependent biomarker.Methods: Thirty-four individuals with subthreshold depression and thirty-one non-depressed individuals were recruited to perform a binocular rivalry task including implicit emotional processing. The participants were required to report their perceived orientations of the rival gratings in the foreground and simultaneously to neglect emotional face stimuli in the background. The participants were retested after an approximately 4-month time interval.Results: Compared to the non-depressed group, the depressive group showed significantly stronger implicit emotional dominance at the initial assessment. However, the abnormality was not observed at the follow-up assessment. More importantly, individuals displaying stronger emotional dominance at the initial assessment were more difficult for improvement in depressive severity at the follow-up assessment. No difference was found regarding the switching rate between the depressive group and the non-depressed controls.Conclusions: The abnormality on emotional dominance for individuals with subthreshold depression is associated with depressive symptoms over time. The current emotional binocular rivalry test may provide an objective state-dependent biomarker for distinguishing depressive individuals from healthy individuals.

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Evidence that eye‐movement profiles do not explain slow binocular rivalry rate in bipolar disorder: support for a perceptual endophenotype

Abstract: The results provide evidence that EM profiles do not explain the slow BR endophenotype for BD, thus indicating that the trait reflects anomalous perceptual processing per se. This perceptual trait can be employed in clinical, genetic, mechanistic and pathophysiological studies.

Cited by 3 publications

References 82 publications

Fluctuations of consciousness, mood, and science: The interhemispheric switch and sticky switch models two decades on

Fluctuations of consciousness, mood, and science: The interhemispheric switch and sticky switch models two decades on

State‐dependent alterations of implicit emotional dominance during binocular rivalry in subthreshold depression

State-dependent alternations of implicit emotional dominance during binocular rivalry in subthreshold depression

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