Evidence that ergovaline acts on serotonin receptors

Dyer, Donald C.

doi:10.1016/0024-3205(93)90555-h

Cited by 106 publications

(109 citation statements)

References 9 publications

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“…In contrast, similar treatment during heat stress (HS) induces hyperthermia above the control level (Spiers et al, 1995(Spiers et al, , 2005a. Fescue toxicosis-induced hyperthermia results from vasoconstriction of peripheral vasculature (Dyer, 1993;Larson et al, 1995) that reduces perfusion of extremities and impedes cutaneous heat loss. A number of experiments (Oliver, 1997;Strickland et al, 1996;Thompson et al, 1950) have repeatedly demonstrated that the vascular endothelium is a primary target of ergopeptine alkaloids found in E+ diets.…”

Section: Introductionmentioning

confidence: 90%

Nitric oxide supplementation alleviates hyperthermia induced by intake of ergopeptine alkaloids during chronic heat stress

Al-Tamimi

Eichen

Rottinghaus

et al. 2007

Journal of Thermal Biology

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Section: Introductionmentioning

confidence: 90%

Nitric oxide supplementation alleviates hyperthermia induced by intake of ergopeptine alkaloids during chronic heat stress

Al-Tamimi

Eichen

Rottinghaus

et al. 2007

Journal of Thermal Biology

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“…Most interestingly, Oliver et al (1998) demonstrated that venous preparations from cattle on E+ diets had an enhanced contractility to an alpha-2 adrenergic agonist. Dyer (1993) reported ergot alkaloids mediated vasoconstriction upon cattle uterine and umbilical veins via a serotinergic mechanism.…”

Section: Animal Toxicosis-tall Fescuementioning

confidence: 99%

Anti-quality factors associated with alkaloids in eastern temperate pasture

Thompson¹,

Stuedemann²,

Hill³

2001

REM

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The greatest anti-quality associated with eastern temperature pasture grasses is the result of ergot alkaloids found in endophyte-infected (Neotyphodium ceonophialum) tall fescue (Festuca arundinacea Schreb.) The relationship between the grass and the endophyte is mutalistic with greater persistence and herbage mass as a result of the endophyte. Ergot alkaloids reduce growth rate, lactation, and reproduction in livestock. Significant effects are the result of elevated body temperature and reduced peripheral blood flow such that necrosis may result. Perturbations also occur in a variety of body systems. Planting new pastures with seed containing a "non-toxic" endophyte appears to be a potential solution. Ergotism results from the ingestion of the scelerotia of Claviceps purpurea containing ergot alkaloids found on seed heads. Ergotism resembles the effects of endophyte-infected tall fescue. Endophyte-infected perennial ryegrass (Lolium perenne L.) contains ergot and lotirem alkaloids that result in reduced growth and tremors. Reed canarygrass (Phalaris Anundinacba L.) contains tryptamine, hordenine and gramine alkaloids that reduce growth. Annual ryegrass (Lolium multiplorum L. may contain galls with cornetoxins which result in neurological signs.

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“…Based on structures alone, the biogenic amines, dopamine and serotonin, suggest modes of actions due to the ergots ergoline ring. It has been demonstrated that ergovaline, the major ergot alkaloid produced in endophyte-infected tall fescue, acts on a serotonin receptor (Dyer 1993;Larson et al 1995). In livestock, ergot alkaloids mimic dopamine and exert an agonistic interaction with the D2 dopamine receptor to inhibit acetylcholine and dopamine release, depress chemosensory activity, inhibit norepinephrine release, and reduce prolactin secretions (Cross et al 1995).…”

Section: Resultsmentioning

confidence: 98%

Chemotaxis Disruption in Pratylenchus Scribneri by Tall Fescue Root Extracts and Alkaloids

et al. 2009

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Tall fescue (Festuca arundinacea) forms a symbiotic relationship with the clavicipitalean fungal endophyte Neotyphodium coenophialum. Endophyte-infected grass is tolerant to nematode, but the factors responsible are unknown. One objective of this work was to determine if root extracts of tall fescue effected chemoreceptor activity of Pratylenchus scribneri by using an in vitro chemoreception bioassay. Another objective was to determine if specific ergot alkaloids (ergovaline, ergotamine, a-ergocryptine, ergonovine), and loline alkaloids, all produced by the fungal endophyte, altered chemotaxis with this bioassay. Methanolic extract from roots altered chemotaxis activities in this nematode but only from roots of plants cultured 45 > or = d, which repelled nematodes. Extracts prepared from noninfected grasses were attractants. This assay indicated that the alkaloids were either repellents or attractants. N-formylloline was an attractant at concentrations of 20 microg/ml and lower, while at higher concentrations it was a repellent. Ergovaline, the major ergot alkaloid produced by the endophyte, was repellent at both high and low concentrations and caused complete death of the nematodes.

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Evidence that ergovaline acts on serotonin receptors

Cited by 106 publications

References 9 publications

Nitric oxide supplementation alleviates hyperthermia induced by intake of ergopeptine alkaloids during chronic heat stress

Nitric oxide supplementation alleviates hyperthermia induced by intake of ergopeptine alkaloids during chronic heat stress

Anti-quality factors associated with alkaloids in eastern temperate pasture

Chemotaxis Disruption in Pratylenchus Scribneri by Tall Fescue Root Extracts and Alkaloids

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