Evidence that endogenous corticotropin-releasing factor suppresses behavioral responses of guinea pig pups to brief isolation in novel surroundings

Hennessy, Michael B.; McInturf, Shawn M; Mazzei, Samuel J.

doi:10.1002/(sici)1098-2302(199707)31:1<39::aid-dev4>3.0.co;2-v

Cited by 9 publications

(3 citation statements)

References 37 publications

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“…As time passes in isolation, probability of recovery by the mother decreases and less conspicuous vocal signals and immobility may represent the best trade off between calling and defense against predators. There is indeed evidence that, in Guinea Pig pups, immobility and plasma cortisol levels increase and vocalization rate decreases with time in isolation (Hennessy et al 1991(Hennessy et al , 1997. The long-note, high rate whistling recorded at the start of an isolation period may be interpreted as the pup's investment in short-term recovery; the short-note, low rate whistles recorded at the end of the isolation period, as a compromise between attention getting and defensive tendencies.…”

Section: Discussionmentioning

confidence: 99%

Isolation induced changes in Guinea Pig Cavia porcellus pup distress whistles

Monticelli

Tokumaru²,

Ades

2004

An. Acad. Bras. Ciênc.

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Guinea Pig Cavia porcellus pups emit high-pitched distress whistles when separated from their mother. In order to assess the influence of the duration of a brief isolation period on whistle acoustic structure, we recorded the distress whistles of six 8-day old pups separated for 15 min from their group in a novel environment and compared the mean values of the first and last 30 whistle notes. Acoustic analysis revealed, throughout the session, a significant decrease in whistle duration, an increase in mean frequency and a tendency for a decrease in number of harmonics in the first part of the note. Results demonstrate that, throughout a brief isolation period, the vocal response of Guinea Pig pups to isolation undergoes structural changes possibly related to time-dependent changes in motivational state.

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Section: Discussionmentioning

confidence: 99%

Isolation induced changes in Guinea Pig Cavia porcellus pup distress whistles

Monticelli

Tokumaru²,

Ades

2004

An. Acad. Bras. Ciênc.

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“…Deprivation-induced locomotor hyperactivity together with the reduced behavioral response towards a familiar acoustic emotional signal may be linked to changes of brain function, e.g., altered serotonergic, dopaminergic, and nitridergic function (Braun, Lange, Metzger, & Poeggel, 2000). These changes may in addition be accompanied by endocrine alterations similar to those that have been found in another precocious animal, the guinea pig (Hennessy, Becker, & O'Neil, 1991;Hennessy, McInturf, & Mazzei, 1997;Hennessy & Moorman, 1989). It remains to be analyzed, using more specific behavioral tests for emotionality, whether the altered behaviors induced in our animals reflect pathological or beneficial changes of behavior and brain function.…”

Section: Repeated Parental Separation Alters Responsiveness Towards Mmentioning

confidence: 94%

Influence of parental deprivation on the behavioral development in Octodon degus: Modulation by maternal vocalizations

Braun

Kremz

Wetzel

et al. 2003

Developmental Psychobiology

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Repeated separation from the family during very early stages of life is a stressful emotional experience which induces a variety of neuronal and synaptic changes in limbic cortical areas that may be related to behavioral alterations. First, we investigated whether repeated parental separation and handling, without separation from the family, leads to altered spontaneous exploratory behavior in a novel environment (open field test) in 8-day-old Octodon degus. Second, we tested whether the parentally deprived and handled animals display different stimulus-evoked exploratory behaviors in a modified open field version, in which a positive emotional stimulus, the maternal call, was presented. In the open field test a significant influence of previous emotional experience was found for the parameters of running, rearing, and vocalization. Parentally deprived degus displayed increased horizontal (running) and vertical (rearing) motoric activities, but decreased vocalization, compared to normal and handled controls. The presentation of maternal vocalizations significantly modified running, vocalization, and grooming activities, which in the case of running activity was dependent on previous emotional experience. Both deprivation-induced locomotor hyperactivity together with the reduced behavioral response towards a familiar acoustic emotional signal are similar to behavioral disturbances observed in human attachment disorders.

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“…Further, SC injection of just the antagonist prior to isolation has the opposite effect on behavior than does CRF. 19, 30 It appears, therefore, that the observed effect of SC‐CRF administration mimics the action of an endogenous CRF system.…”

Section: Crf and The Behavioral Responses Of Isolated Youngmentioning

confidence: 97%

Short‐ and Long‐term Consequences of Corticotropin‐releasing Factor in Early Development

Hennessy¹,

Davis²,

McCrea³

et al. 1999

Annals of the New York Academy of Sciences

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Corticotropin-releasing factor (CRF) mediates various stress-related responses in adult animals. Little is known about the effects of CRF during early development. Young mammals often vocalize when isolated in novel surroundings. Heightened levels of CRF inhibit vocalizing in isolated rat and guinea pig pups. Still lower levels of CRF may facilitate or permit vocalizing in rat pups. In guinea pigs, CRF appears to move pups from an initial active, to a subsequent passive, stage of behavioral responsiveness. CRF activity prior to birth can also affect the young. Exposing pregnant female rats to stressors during the last trimester of pregnancy alters the morphological and behavioral development of the offspring. Effects of gestational stress can be mimicked by injecting pregnant females with CRF during the last trimester. CRF appears to mediate both short- and long-term responses to stressors during developmental in rodents.

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Evidence that endogenous corticotropin-releasing factor suppresses behavioral responses of guinea pig pups to brief isolation in novel surroundings

Cited by 9 publications

References 37 publications

Isolation induced changes in Guinea Pig Cavia porcellus pup distress whistles

Isolation induced changes in Guinea Pig Cavia porcellus pup distress whistles

Influence of parental deprivation on the behavioral development in Octodon degus: Modulation by maternal vocalizations

Short‐ and Long‐term Consequences of Corticotropin‐releasing Factor in Early Development

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