Evidence that angiogenesis lags behind neuron and astrocyte growth in experience‐dependent plasticity

Wallace, Chris S.; Withers, Ginger S.; Farnand, Alex W.; Lobingier, Braden T.; McCleery, Ellen

doi:10.1002/dev.20559

Cited by 10 publications

(6 citation statements)

References 137 publications

(125 reference statements)

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“…The specific reasons for changes in plasticity with age may stem from metabolic or transcriptional changes associated with ageing, such as a decline in growth hormones like IGF‐1 or BDNF (Barzilai, Huffman, Muzumdar, & Bartke, ; Kirk I Erickson et al, ) or with changes in angiogenesis. Indeed, it has been suggested that the neuronal capacity for plasticity may be constrained by the rate of vascularization (Wallace, Withers, Farnand, Lobingier, & McCleery, ). However, further work is needed to fully elucidate the role of these factors in exercise‐induced changes in hippocampal plasticity and neurogenesis.…”

Section: Discussionmentioning

confidence: 99%

Differential effects of adolescent and adult‐initiated exercise on cognition and hippocampal neurogenesis

et al. 2018

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Adolescence is a critical period for postnatal brain maturation and thus a time when environmental influences may affect cognitive processes in later life. Exercise during adulthood has been shown to increase hippocampal neurogenesis and enhance cognition. However, the impact of exercise initiated in adolescence on the brain and behavior in adulthood is not fully understood. The aim of this study was to compare the impact of voluntary exercise that is initiated during adolescence or early adulthood on cognitive performance in hippocampal‐dependent and ‐independent processes using both object‐based and touchscreen operant paradigms. Adult (8 week) and adolescent (4 week) male Sprague–Dawley rats had access to a running wheel (exercise) or were left undisturbed (sedentary control) for 4 weeks prior to behavioral testing and for the duration of the experiment. Results from touchscreen‐based tasks showed that reversal learning was enhanced by both adult and adolescent‐initiated exercise, while only exercise that began in adolescence induced a subtle but transient increase in performance on a location discrimination task. Spontaneous alternation in the Y‐maze was impaired following adolescent onset exercise, while object memory was unaffected by either adult or adolescent‐initiated exercise. Adolescent‐initiated exercise increased the number of hippocampal DCX cells, an indicator of neurogenesis. It also promoted the complexity of neurites on DCX cells, a key process for synaptic integration, to a greater degree than adult‐initiated exercise. Together the data here show that exercise during the adolescent period compared to adulthood differentially affects cognitive processes and the development of new hippocampal neurons in later life.

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Section: Discussionmentioning

confidence: 99%

Differential effects of adolescent and adult‐initiated exercise on cognition and hippocampal neurogenesis

et al. 2018

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“…Как показано в многочисленных исследованиях у животных, обогащение среды оказывает на головной мозг широкий спектр воздействий, включая повышение уровня нейротрофических факторов и повышение экспрессии генов, контролирующих нейронную сигнализацию и синтез белка [52]. Обогащение среды и обучение новым навыкам увеличивает скопление отростков нейронов (нейропиль) в коре [64] и приводит к структурным изменениям в зубчатой извилине, поясной коре и мозолистом теле [6].…”

Section: реактивация нейропластичности и обогащение средыunclassified

Perspective of application of nonlinear stimulation therapy in the treatment of traumatic brain injuries and maintenance of cognitive functions in the elderly

2018

V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY

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Cognitive decline characterizes normal physiological aging and is aggravated by the development of age-related neurodegenerative pathology and traumatic brain damage (TBI). Te review analyzes widely discussed in the scientifc literature non-drug methods of rehabilitation of patients with TBI and elderly people suﬀering from cognitive decline, including the paradigm of enrichment of the environment, cognitive and physical training and various types of stimulation therapy and their shortcomings. Special attention is paid to the advantages of fractal stimulation of the brain by complex-structured optical signals and sensory stimuli of another modality. It is assumed that the use of new approaches to neurorehabilitation, which increase the potential of neuroplasticity will also allow strengthening the therapeutic and learning impacts of any other methods of training and treating the brain.

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“…The cortex of rodents exposed to enriched environments during young adulthood show increased levels of neurotrophic factors and higher expression of genes controlling neuronal signalling/growth, RNA, and protein synthesis (Rampon et al 2000a ; Torasdotter et al 1998 , 1996 ). Also, enriched environments and new learning have been shown to increase neuropil in the cortex (Wallace et al 2011 ), and result in structural changes in the dentate gyrus, cingulate cortex and corpus callosum (Blumenfeld-Katzir et al 2011 ). These animal findings support the use of this apparently benign behavioural approach to enhance brain health/function in TBI.…”

Section: Environmental Enrichment Provides Opportunities For Intervenmentioning

confidence: 99%

Negative Neuroplasticity in Chronic Traumatic Brain Injury and Implications for Neurorehabilitation

et al. 2014

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Based on growing findings of brain volume loss and deleterious white matter alterations during the chronic stages of injury, researchers posit that moderate-severe traumatic brain injury (TBI) may act to “age” the brain by reducing reserve capacity and inducing neurodegeneration. Evidence that these changes correlate with poorer cognitive and functional outcomes corroborates this progressive characterization of chronic TBI. Borrowing from a framework developed to explain cognitive aging (Mahncke et al., Progress in Brain Research, 157, 81–109, 2006a; Mahncke et al., Proceedings of the National Academy of Sciences of the United States of America, 103(33), 12523–12528, 2006b), we suggest here that environmental factors (specifically environmental impoverishment and cognitive disuse) contribute to a downward spiral of negative neuroplastic change that may modulate the brain changes described above. In this context, we review new literature supporting the original aging framework, and its extrapolation to chronic TBI. We conclude that negative neuroplasticity may be one of the mechanisms underlying cognitive and neural decline in chronic TBI, but that there are a number of points of intervention that would permit mitigation of this decline and better long-term clinical outcomes.

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Evidence that angiogenesis lags behind neuron and astrocyte growth in experience‐dependent plasticity

Cited by 10 publications

References 137 publications

Differential effects of adolescent and adult‐initiated exercise on cognition and hippocampal neurogenesis

Differential effects of adolescent and adult‐initiated exercise on cognition and hippocampal neurogenesis

Perspective of application of nonlinear stimulation therapy in the treatment of traumatic brain injuries and maintenance of cognitive functions in the elderly

Negative Neuroplasticity in Chronic Traumatic Brain Injury and Implications for Neurorehabilitation

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