1991
DOI: 10.1111/j.1476-5381.1991.tb12298.x
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Evidence that an l‐arginine/nitric oxide dependent elevation of tissue cyclic GMP content is involved in depression of vascular reactivity by endotoxin

Abstract: 1 The aim of this investigation was to study the relationship between contractile responsiveness, activation of the L-arginine pathway and tissue levels of guanosine 3': 5'-cyclic monophosphate (cylic GMP) in aortic rings removed from rats 4h after intraperitoneal administration of bacterial endotoxin (E.coli. lipopolysaccharide, LPS, 20mg kg-1). 2 LPS-treatment resulted in a reduction of the sensitivity and maximal contractile response to noradrenaline (NA). 3 Depression of the maximal contractile response wa… Show more

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Cited by 129 publications
(56 citation statements)
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“…In intact liver under basal conditions, NO is produced by eNOS in sinusoidal endothelial cells (Shah et al, 1997). LPS is a potent inducer of iNOS in multiple cell types in the liver, most of all in Kupffer cells, but also in hepatocytes and HSC (Fleming et al, 1991). In our experiment, we observed 32-fold increase in iNOS mRNA expression in total liver of endotoxemic rats.…”
Section: Discussionsupporting
confidence: 64%
“…In intact liver under basal conditions, NO is produced by eNOS in sinusoidal endothelial cells (Shah et al, 1997). LPS is a potent inducer of iNOS in multiple cell types in the liver, most of all in Kupffer cells, but also in hepatocytes and HSC (Fleming et al, 1991). In our experiment, we observed 32-fold increase in iNOS mRNA expression in total liver of endotoxemic rats.…”
Section: Discussionsupporting
confidence: 64%
“…The overproduction of NO by iNOS in sepsis results in increased production of cGMP contributing to the refractory hypotension observed with septic shock. Numerous animal studies demonstrate large increases of NO after exposure to lipopolysaccharide (i.e., endotoxin) with resultant hypotension [62][63][64][65][66][67].…”
Section: The No-cgmp Pathway In Anaphylaxis and The Role Of Methylenementioning
confidence: 99%
“…Finally, iNOS deficient mice have been found to be resistant to vascular hypocontractility (Gunnett et al, 1998). Accordingly, iNOS, which generates large amounts of NO, is likely to be a critical mediator of the diminished vascular contractility in sepsis (Fleming et al, 1991;Griffiths et al, 1995;Hom et al, 1995).…”
Section: Vascular Hyporesponsiveness To Vasocontractile Stimulimentioning
confidence: 99%