Evidence that albumin is not a suitable marker of body composition-related nutritional status in elderly patients

Bouillanne, O.; Hay, Phasaro; Liabaud, B.; Duché, C; Cynober, Luc; Aussel, Christian

doi:10.1016/j.nut.2009.12.007

Cited by 54 publications

(46 citation statements)

References 38 publications

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“…It has been previously suggested that this increase may be linked to the progression of CKD in HD patients; however we could not demonstrate a significant difference between the obese and malnourished groups. Moreover, there was no connection between BMI and serum albumin levels in HD patients supporting the findings of other studies where albumin was an unreliable marker of the nutritional status in CKD and elderly patients [36,37].…”

Section: Discussionsupporting

confidence: 86%

Effect of Nutritional Status on Human Paraoxonase-1 Activity in Patients with Chronic Kidney Disease

Sztanek

Serés

Harangi

et al. 2012

Kidney Blood Press Res

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Background/Methods: The association between nutritional status, antioxidant human paraoxonase-1 (PON1) activity and low grade inflammation in hemodialized (HD) patients with chronic kidney disease (CKD) is unclear. The aim of this study was to determine PON1 paraoxonase and lactonase activities, ADMA, adiponectin and leptin concentrations, and to clarify the relationship between paraoxonase activity and a set of cardiovascular risk factors in malnourished, normal weight and obese HD patients; 114 HD patients with end-stage renal failure were enrolled. Results: Leptin levels were significantly higher and PON1 paraoxonase activities were significantly lower in obese patients compared to the other groups. Plasma adiponectin concentration was significantly lower in obese subjects compared to malnourished patients. Paraoxonase activity was negatively correlated with CRP level in HD and malnourished patients. Furthermore, we found significant inverse correlation between paraoxonase activity and BMI in the whole patient group. In multiple regression analysis, PON1 lactonase activity, CRP level and leptin concentration proved to be independent predictors of paraoxonase activity. Conclusion: Despite the previous findings of reverse epidemiology for the mortality rate of HD patients, further studies are needed to clarify the effects of nutritional state on atherosclerosis in obese and malnourished patients with end-stage renal failure.

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Section: Discussionsupporting

confidence: 86%

Effect of Nutritional Status on Human Paraoxonase-1 Activity in Patients with Chronic Kidney Disease

Sztanek

Serés

Harangi

et al. 2012

Kidney Blood Press Res

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“…This latter group has the smallest increase in FIM motor score. 6 As there is evidence that serum albumin is not a suitable marker of body composition-related nutritional status in elderly patients, 7 and that hemoglobin may be affected by several conditions not related to nutritional status, it is necessary to measure both anthropometric and laboratory data in order to obtain accurate assessment of nutrition.…”

Section: Malnutrition Often Occurs In Disabled Patientsmentioning

confidence: 99%

Association of Nutrition Status and Rehabilitation Outcome in the Disuse Syndrome: a Retrospective Cohort Study

Wakabayashi

Sashika

2011

Gen. Med.

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“…On the other hand, in patients with marked infection, serum albumin levels are not a suitable nutritional marker, because serum albumin decreases with infection (31,32).…”

Section: Discussionmentioning

confidence: 99%

Effect of Long-Term Proton Pump Inhibitor Therapy on Nutritional Status in Elderly Hospitalized Patients

Nakamichi

Wakabayashi

2016

J Nutr Sci Vitaminol

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SummaryThe purpose was to investigate the association between proton pump inhibitor (PPI) therapy and nutritional status in elderly hospitalized patients. Participants were 190 elderly patients admitted to the long-term care wards, convalescence rehabilitation wards, and community integrated care wards in January 2015. Nutritional status was assessed using the mini nutritional assessment short-form (MNA-SF). The PPI use group was compared with the PPI non-use group regarding nutrition status. Logistic regression analysis was used to examine whether the period of PPI therapy was associated independently with malnutrition following adjustment for covariates including gender, age, and serum albumin level. Forty-one patients were male (22%) and 149 patients were female (78%), with a mean age of 85.468.4. Fifty-three patients (28%) took PPIs (with a median prescription period of 91 d, ranging from 51 to 227). With a MNA-SF score of 7 points or lower designated as malnutrition, there was no significant difference in nutritional status between the PPI and non-PPI groups (p50.172). The median MNA-SF scores in the PPI and non-PPI groups were 9 vs 7 points, respectively. Logistic regression analysis showed that long-term PPI therapy (odds ratio, 0.994; 95% confidence interval 0.990-0.999) was significantly associated with improved nutritional status. The presence or absence of PPI therapy is not associated with malnutrition in elderly hospitalized patients. Longer-term PPI therapy may improve nutritional status.

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Evidence that albumin is not a suitable marker of body composition-related nutritional status in elderly patients

Cited by 54 publications

References 38 publications

Effect of Nutritional Status on Human Paraoxonase-1 Activity in Patients with Chronic Kidney Disease

Effect of Nutritional Status on Human Paraoxonase-1 Activity in Patients with Chronic Kidney Disease

Association of Nutrition Status and Rehabilitation Outcome in the Disuse Syndrome: a Retrospective Cohort Study

Effect of Long-Term Proton Pump Inhibitor Therapy on Nutritional Status in Elderly Hospitalized Patients

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