Evidence That a New Slow-Delivery Type of Superoxide Dismutase Improves the Survival of Swine Warm Ischemia-Damaged Transplanted Liver

Hasuoka, Hideaki; Sakagami, K; Takasu, Shinji; Morisaki, Futoshi; Kawamura, Takumi; Haisa, Minoru; Oiwa, Takashi; Kurozumi, Yoichi; Inagaki, Masaru; Niguma, Takefumi; Inoue, Masayasu; Orita, Kunzo

doi:10.1097/00007890-199007000-00033

Cited by 4 publications

(1 citation statement)

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“…Many of them were about liver ischemia during hepatic resection, and this procedure could be securely performed with ischemia lasting 60-85 min (16). In contrast, in experimental liver transplantation using a large animal, even 30 min warm ischemia could be life threatening if no supportive treatment was given (17,18). In clinical organ procurement from NHBD, the most important principle of the so-called superrapid technique is that the organs must be rapidly cooled prior to any attempts at dissection.…”

Section: Resultsmentioning

confidence: 99%

Study of the Changes of Serum Hyaluronic Acid During Porcine Liver Transplantation: Influence of Warm Ischemia

et al. 1996

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Twelve porcine liver transplantations were performed to investigate whether serum hyaluronic acid (HA) serves as a marker of warm ischemic injury. Group 1 was a control without warm ischemia (n = 7), and pigs in Group 2 were sacrificed by intracardiac KC1 injection 60 min before harvesting (n = 5). All pigs survived more than 4 days in Group 1. In Group 2, all died within 2 days due to graft failure. Arterial and hepatic venous glutamic‐oxaloacetic transaminase (GOT) in Group 2 were higher after revascularization. However, there were no differences between the 2 groups in arterial and hepatic venous HA levels. HA clearance by the graft also showed no differences between the groups. Although GOT reflected the degree of warm ischemia, HA and its hepatic clearance were not influenced by warm ischemic damage. In conclusion, HA was not thought to serve as a marker of liver injury when the graft suffered from warm ischemia.

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Section: Resultsmentioning

confidence: 99%