Evidence supporting zinc as an important antioxidant for skin

Rostan, Elizabeth F.; DeBuys, Holly V.; Madey, Doren L.; Pinnell, Sheldon R.

doi:10.1046/j.1365-4362.2002.01567.x

Cited by 217 publications

(156 citation statements)

References 49 publications

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“…It is a major antioxidant trace element through zinc-induced metallothionein synthesis (Bell and Vallee, 2009), Zn-Cu superoxide dismutase, competition with iron and copper in Fenton's reaction and thiol group protection (Powell, 2000). Zinc has important roles particularly in the physiopathology of eye (Grahn et al, 2001;Ugarte and Osborne, 2001), skin (Rostan et al, 2002;Lansdown et al, 2007), bone (Peretz et al, 2001;Palacios, 2006) and brain (Takeda, 2001;Frazzini et al, 2006). Zinc is also crucial for immunity (Fraker and King, 2004;Haase and Rink, 2009) and hormonal excretions.…”

Section: Introductionmentioning

confidence: 99%

Determinants of serum zinc concentrations in a population of French middle-age subjects (SU.VI.MAX cohort)

et al. 2010

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Background/Objectives: Few studies have been conducted on determinants of serum zinc concentration, especially in France. The aim of this study was to investigate the relationships between serum zinc concentrations, and age, education, living area and life style in a large sample cohort of French adults. Subjects/Methods: Blood samples were collected after 12-h fasting in French adults (7448 women, 35-65 years old and 4926 men, 45-65 years old) participating to the SUpplementation in AntioXidant VItamins and Minerals cohort at enrolment. Serum zinc was determined by flame atomic absorption. Results: Serum zinc concentration was lower in women (mean: 12.9 mmol/l, 95% confidence interval: 9.2-16.6 mmol/l) compared with men (mean: 13.4 mmol/l, 95% confidence interval: 9.7-17.1 mmol/l, Po0.0001). In total, 10% of the women showed serum zinc values o10.7 mmol/l and 10% of the men showed serum zinc values o11.3 mmol/l. Age was negatively associated with serum zinc only in men (P ¼ 0.001). In women, a positive association between smoking and serum zinc concentration (P ¼ 0.0003), and a negative relationship between highest education level and serum zinc concentration (P ¼ 0.01) were observed. With regard to geographical areas, the highest serum zinc concentrations were found in the Center, and the lowest in the Southwest of France for both men and women. The association between serum zinc concentrations and food categories or macronutrient intake disappeared after stratifying by gender. Conclusions: Age, gender and geographic area seem the main determinants of serum zinc concentrations in this study.

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Section: Introductionmentioning

confidence: 99%

Determinants of serum zinc concentrations in a population of French middle-age subjects (SU.VI.MAX cohort)

et al. 2010

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“…Among the essential trace metals, zinc is an important element of more than 200 metalloenzymes, including the antioxidant superoxide dismutase (SOD) enzyme (3). In the cardiovascular system, zinc deficiency impairs the integrity of the endothelial cells (4) while favoring lipid peroxidation by enhancing oxidative-stress (5) and therefore may play a critical role in atherogenesis (6).…”

Section: Introductionmentioning

confidence: 99%

The +838 C/G MT2A Polymorphism, Metals, and the Inflammatory/Immune Response in Carotid Artery Stenosis in Elderly People

Giacconi

Muti

Malavolta

et al. 2007

Mol Med

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Carotid artery stenosis (CS) is a well-established risk factor for stroke. Increased proinflammatory chemokines, enhanced metallothionein (MT), and altered metal homeostasis may play roles in atherosclerosis progression and plaque destabilization. MT may sequester zinc during chronic inflammation, provoke zinc deficiency, and modulate NK cell cytotoxicity. A recent investigation of older patients with diabetes and atherosclerosis showed an association between the -209 A/G MT2A polymorphism, CS, and zinc status. In this study, we evaluated the relationship between two MT2A polymorphisms (-209 and + 838 locus), metal status, and inflammatory/immune response in older patients with CS only (the CS1 group) or with CS and previous cerebrovascular episodes (transient ischemic attack or stroke) (the CS2 group). A total of 506 individuals (188 CS1, 100 CS2, and 218 healthy controls) were studied. Atherosclerotic patients (CS1 and CS2) showed increased levels of MT, MCP-1, and RANTES, reduced NK cell cytotoxicity, and altered trace element concentrations (zinc, copper, magnesium, iron). The +838 C/G MT2A polymorphism was differently distributed in CS1 and CS2 patients, who displayed the GG genotype (C-) with significantly higher frequency than elderly controls. C-carriers showed increased MCP-1 and decreased NK cell cytotoxicity, CD56+ cells, and intracellular zinc availability along with decreased zinc, copper, and magnesium content in erythrocytes and increased iron in plasma. C-carriers also showed a major incidence of soft carotid plaques. In conclusion, the +838 C/G MT2A polymorphism seems to influence inflammatory markers, zinc availability, NK cell cytotoxicity, and trace element status, all of which may promote CS development.

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“…The author also indicated that a numerical trend of improvement of WHC of breast meat was observed when birds fed various ratios of supplemental manganese versus zinc (Saenmahayak, 2007). Zinc act as an antioxidant (Rostan et al, 2002) that can reduce oxidation in the muscle tissue. Increased levels of oxidation can damage cell membranes, reducing their integrity and allowing seepage of intracellular fluids.…”

Section: Resultsmentioning

confidence: 99%

Influence of Various Levels of Organic Zinc on the Live Performance, Meat Quality Attributes, and Sensory Properties of Broiler Chickens

Salim¹,

Lee²,

Jo³

et al. 2011

Korean Journal for Food Science of Animal Resources

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The influence of supplementing diets with various levels of organic zinc (OZ) on the performance, meat quality attributes, and sensory properties of broiler chickens was investigated. A total of 3,200 1-d-old female broiler chicks were randomly allotted to 16 floor pens (replicates) with 200 birds per pen. A corn-wheat-soybean meal basal diet (control) was formulated and 20 ppm OZ (20 OZ), 40 ppm OZ (40 OZ), or 80 ppm OZ (80 OZ) was added to the basal diet to form four dietary treatments with four replicates per treatment. Live performance of broiler chickens, meat quality, and sensory properties were evaluated. The results showed no significant difference among the treatments for live performance of broiler chickens. Significant increases (p<0.05) in thigh skin epidermis and dermis thickness were shown in the OZ supplementation groups; however, no effect of OZ on the thickness of back skin epidermis or dermis was found. Dietary OZ levels did not affect the pH of breast and thigh meat or the water holding capacity (WHC) of thigh meat, but the WHC of breast meat increased significantly (p<0.05) when birds were fed 40 OZ and 80 OZ. Results of a sensory analysis showed no differences among the dietary treatments. In conclusion, dietary OZ did not affect live performance or sensory properties of broiler chickens but did increase the WHC of breast meat and thickness of skin layers; thus, improving carcass quality in broiler chickens.

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Evidence supporting zinc as an important antioxidant for skin

Cited by 217 publications

References 49 publications

Determinants of serum zinc concentrations in a population of French middle-age subjects (SU.VI.MAX cohort)

Determinants of serum zinc concentrations in a population of French middle-age subjects (SU.VI.MAX cohort)

The +838 C/G MT2A Polymorphism, Metals, and the Inflammatory/Immune Response in Carotid Artery Stenosis in Elderly People

Influence of Various Levels of Organic Zinc on the Live Performance, Meat Quality Attributes, and Sensory Properties of Broiler Chickens

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