2018
DOI: 10.1111/joim.12842
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Evidence supporting the best clinical management of patients with multimorbidity and polypharmacy: a systematic guideline review and expert consensus

Abstract: The complexity and heterogeneity of patients with multimorbidity and polypharmacy renders traditional disease‐oriented guidelines often inadequate and complicates clinical decision making. To address this challenge, guidelines have been developed on multimorbidity or polypharmacy. To systematically analyse their recommendations, we conducted a systematic guideline review using the Ariadne principles for managing multimorbidity as analytical framework. The information synthesis included a multistep consensus pr… Show more

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Cited by 209 publications
(187 citation statements)
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References 57 publications
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“…These results are consistent with the literature, which emphasizes that patients with multiple chronic diseases face a heavier burden than the general population . Clinicians also believe that the complexity associated with this burden makes it difficult to manage the patients' condition because it requires higher levels of care and services (ie, higher intensity of care in terms of financial and professional resources) compared to the general population …”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…These results are consistent with the literature, which emphasizes that patients with multiple chronic diseases face a heavier burden than the general population . Clinicians also believe that the complexity associated with this burden makes it difficult to manage the patients' condition because it requires higher levels of care and services (ie, higher intensity of care in terms of financial and professional resources) compared to the general population …”
Section: Discussionsupporting
confidence: 90%
“…20 Clinicians also believe that the complexity associated with this burden makes it difficult to manage the patients' condition because it requires higher levels of care and services (ie, higher intensity of care in terms of financial and professional resources) compared to the general population. 21,22 Another factor that has an impact on the burden of disease is the number of decisions to be made, several times per week or month.…”
Section: Discussionmentioning
confidence: 99%
“…It is therefore essential to continue developing evidence-based guidelines (e.g. Muth et al [24,25]) to design care pathways that are sensitive to the needs of multimorbid patients. These guidelines should also be developed in a simplified format to help patients and lay persons comprehend them, particularly the elements that require specific action from the patients themselves, for example lifestyle changes (nutrition, physical activity, etc.).…”
Section: Disease-specific Models and Guidelines In Populations With Amentioning
confidence: 99%
“…Response to chronic conditions is frequently complicated by multimorbidity, the simultaneous presence of multiple health conditions in an individual [2][3][4][5]. Multimorbidity challenges usual care delivery, which is frequently structured around pathways of care for single diseases [6][7][8][9][10]. Key principles have been proposed for the design of high-performing health systems that meet the complex needs of people with multimorbidity, ranging from patient and caregiver engagement, to information systems, alignment of funding and incentives [11,12].…”
Section: Introductionmentioning
confidence: 99%