Evidence supporting antioxidant action of adipose-derived stem cells: Protection of human dermal fibroblasts from oxidative stress

Kim, Won Serk; Park, Byung Soon; Kim, Hyung Ki; Park, Jeong‐Soo; Kim, Kea Jeung; Choi, Joon Seok; Chung, Suk Jae; Kim, Dae Duk; Sung, Jong Hwan

doi:10.1016/j.jdermsci.2007.08.004

Cited by 229 publications

(158 citation statements)

References 22 publications

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“…Kim et al [72] have shown the role of different cytokines in controlling fibroblast proliferation/migration, which could obviously affect the time required for wounds to heal. Moreover, they have [73] also shown that ASCs could protect fibroblasts from oxidative stress. Although the authors did not attribute these results to a specific factor, the paper refers to a proteomic based analysis of ASCs CM that reveal the presence of different soluble factors that might be involved in this process.…”

Section: Vascularizationmentioning

confidence: 98%

Adipose Tissue Derived Stem Cells Secretome: Soluble Factors and Their Roles in Regenerative Medicine

Salgado

Reis²,

Sousa³

et al. 2010

CSCR

502

196

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Stem cells have been long looked at as possible therapeutic vehicles for different health related problems. Among the different existing stem cell populations, Adipose derived Stem Cells (ASCs) have been gathering attention in the last 10 years. When compared to other stem cells populations and sources, ASCs can be easily isolated while providing higher yields upon the processing of adipose tissue. Similar to other stem cell populations, it was initially thought that the main potential of ASCs for regenerative medicine approaches was intimately related to their differentiation capability. Although this is true, there has been an increasing body of literature describing the trophic effects of ASCs on the protection, survival and differentiation of a variety of endogenous cells/tissues. Moreover, they have also shown to possess an immunomodulatory character. This effect is closely related to the ASCs' secretome and the soluble factors found within it. Molecules such as hepatocyte growth factor (HGF), granulocyte and macrophage colony stimulating factors, interleukins (ILs) 6, 7, 8 and 11, tumor necrosis factor-(TNF-), vascular endothelial growth factor (VEGF), brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), adipokines and others have been identified within the ASCs' secretome. Due to its importance regarding future applications for the field of regenerative medicine, we aim, in the present review, to make a comprehensive analysis of the literature relating to the ASCs' secretome and its relevance to the immune and central nervous system, vascularization and cardiac regeneration. The concluding section will highlight some of the major challenges that remain before ASCs can be used for future clinical applications.

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Section: Vascularizationmentioning

confidence: 98%

Adipose Tissue Derived Stem Cells Secretome: Soluble Factors and Their Roles in Regenerative Medicine

Salgado

Reis²,

Sousa³

et al. 2010

CSCR

502

196

View full text Add to dashboard Cite

show abstract

“…MSC-conditioned media has also been seen to contain these anti-oxidative factors including G-CSF, GM-CSF and IL-12, as reviewed by Kim et al (140). In addition, evidence has supported that MSC and its conditioned media respectively decrease oxidative damage in culture when fibroblast cells are exposed to oxidative damage-inducing environments such as UVB (141) or tert-butyl hydroperoxide (tbOOH) (142). In addition, research indicates that MSC posses not only considerable ability to support oxidative stress by producing anti-oxidative mediators, but may actually be stimulated by hipoxia-induced ROS (reactive oxigen species).…”

Section: Anti-oxidative Factorsmentioning

confidence: 99%

How do Mesenchymal Stem Cells Repair?

Semedo¹,

Burgos-Silva²,

Donizetti-Oliveira³

et al. 2011

Stem Cells in Clinic and Research

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“…MSCs lack expression of hematopoietic markers as CD 19 , CD 45 , CD 34 or HLA-DR and show positivity for CD 73 , CD 90 and CD 105 [16]. CD 105 (Endoglin) is a membrane glycoprotein and part of the transforming growth factor-β receptor complex.…”

Section: Introductionmentioning

confidence: 99%

“…MSCs exert their effects through their antioxidant properties. MSCs exhibited antioxidant activity through the effect on the levels of glutathione, and superoxide dismutase, and modulating the pathways of antioxidant-related protein activation [19,20]. Furthermore, Kim et al [21] suggested that early intravenous injection of MSCs after acute spinal cord injury may prevent further damage through enhancement of antioxidative mechanisms, without inducing adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Mesenchymal Stem Cells vs. Estradiol Benzoate or Avosoya on the Cerebellar Cortex of Ovariectomized Adult Albino Rats

Ahmed¹,

Abdelrahman²,

Shalaby³

2017

J Cytol Histol

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Alterations in hormone levels during menopause affect cognitive function and brain chemistry. Stem cell therapy in nervous system disorders is a growing field. The present research aimed to compare the effect of MSCs with that of estradiol benzoate or avosoya on the cerebellum of ovariectomized rats. Fifty eight adult female Wistar albino rats were classified into five groups. Control group (Group I) and four ovariectomized groups. Group II (ovariectomized rats received no treatment), Group III (injected subcutaneously with estradiol benzoate), Group IV (received avosoya orally) and Group V (treated with human umbilical cord blood derived mesenchymal stem cells [HUCBMSCs]). Cerebellar sections were stained with hematoxylin and eosin and cresyl fast violet. Immunoperoxidase reaction of glial fibrillary acidic protein (GFAP), estrogen receptor beta (Erβ) and Bax protein was also done. HUCBMSCs homing in rat cerebellum were detected by human albumin gene. Antioxidant enzyme levels were also measured in cerebellum homogenate. Decreased density of neurons in the three cortical layers with vacuolations and distorted Purkinje cells with pyknotic nuclei were observed in Group II. Group III cerebellar cortex showed normal architecture but some Purkinje cells had pyknotic nuclei. Group IV showed normal neuronal cells in the three cortical layers. Group V Purkinje cells were pyriform with vesicular nuclei, and basophilic cytoplasm. Small rounded cells with deeply stained nuclei appeared in the granular layer. In conclusion: estradiol benzoate and avosoya improve ovariectomy-induced cerebellar alteration, and MSCs show promising results in this field.

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Evidence supporting antioxidant action of adipose-derived stem cells: Protection of human dermal fibroblasts from oxidative stress

Cited by 229 publications

References 22 publications

Adipose Tissue Derived Stem Cells Secretome: Soluble Factors and Their Roles in Regenerative Medicine

Adipose Tissue Derived Stem Cells Secretome: Soluble Factors and Their Roles in Regenerative Medicine

How do Mesenchymal Stem Cells Repair?

Therapeutic Potential of Mesenchymal Stem Cells vs. Estradiol Benzoate or Avosoya on the Cerebellar Cortex of Ovariectomized Adult Albino Rats

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