Evidence, Policy, and E-Cigarettes — Will England Reframe the Debate?

Green, Sharon H.; Bayer, Ronald; Fairchild, Amy L.

doi:10.1056/nejmp1601154

Cited by 76 publications

(52 citation statements)

References 1 publication

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“…There is significant debate around the individual and population implications of e-cigarette use [39][40][41][42][43][44][45] . Our study is not without limitations.…”

Section: Discussionmentioning

confidence: 99%

Acute effects of short term use of e-cigarettes on airways physiology and respiratory symptoms in smokers with and without airways obstructive diseases and in healthy non smokers

Palamidas¹,

Tsikrika²,

Κatsaounou³

et al. 2017

Tob. Prev. Cessation

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BACKGROUND Although the use of e-cigarettes is increasing worldwide, their short and long-term effects remain undefined. We aimed to study the acute effect of short-term use of e-cigarettes containing nicotine on lung function and respiratory symptoms in smokers with airways obstructive disease (COPD, asthma), "healthy" smokers, and healthy never smokers. METHODS Respiratory symptoms, vital signs, exhaled NO, airway temperature, airway resistance (Raw), specific airway conductance (sGaw) and single nitrogen breath test were assessed before and immediately after short term use of an e-cigarette containing 11mg of nicotine among adults with COPD, asthma, ''healthy" smokers, and never-smokers. The effect of the use of nicotine-free e-cigarettes among ''healthy" never smokers was also studied. RESULTS The majority of participants reported acute cough. Short term use of nicotine e-cigarettes was associated: a) with increased heart rate in all subjects except in the COPD group, b) decreased oxygen saturation in "healthy" and COPD smokers, c) increased Raw in asthmatic smokers, "healthy" smokers, and healthy never smokers, d) decreased sGaw in healthy subjects, and e) changed slope of phase III curve in asthmatic smokers. Short-term use of nicotine-free e-cigarettes increased Raw and decreased sGaw among healthy never smokers. CONCLUSIONS Short-term use of an e-cigarette has acute effects on airways physiology and respiratory symptoms in COPD smokers, asthmatic smokers, "healthy" smokers and healthy never smokers. E-cigarette use was associated with effects in ''healthy" never smokers irrespectively of nicotine concentration. More studies are needed to investigate both short and long-term effects of e-cigarette use

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“…There is significant debate around the individual and population implications of e-cigarette use [39][40][41][42][43][44][45] . Our study is not without limitations.…”

Section: Discussionmentioning

confidence: 99%

Acute effects of short term use of e-cigarettes on airways physiology and respiratory symptoms in smokers with and without airways obstructive diseases and in healthy non smokers

Palamidas¹,

Tsikrika²,

Κatsaounou³

et al. 2017

Tob. Prev. Cessation

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“…E-cigarettes are devices that vaporise a chemical liquid mixture, in most cases including nicotine, which is inhaled by users. A few years after e-cigarette entrance in the market, its popularity and use substantially grew worldwide (Green et al, 2016). In 2014 prevalence of ever and current e-cigarette users was among US adults 12.6% and 3.7%, respectively (Schoenborn and Gindi, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…The scientific community has sparked a huge debate to understand whether e-cigarettes should be considered a disruptive technology that increase quitting smoking and provide a safe alternative to cigarettes, or a threat to tobacco control that will allow the tobacco industry to subvert policies, renormalize smoking, recruit new smokers, and promote smoking in young people (Green et al, 2016;Yeh et al, 2016). One Cochrane review suggested that there is evidence from two randomized controlled trials (RCTs), that e-cigarettes may help smokers to quit in the long term compared with placebo e-cigarettes, even though under the GRADE system the overall quality of the evidence was judged as 'low' or 'very low', because of imprecision due to the small number of trials (Hartmann-Boyce et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Electronic cigarette use as an aid to quit smoking in the representative Italian population PASSI survey

Gorini

Ferrante

Quarchioni

et al. 2017

Preventive Medicine

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This study explored electronic cigarette (e-cigarette) use as an aid to quit smoking and compared abstinence rates for different quitting methods in a representative sample of the Italian population. In the 2014–2015 PASSI survey, the ongoing Italian behavioural risk factor surveillance system, 6112 adults who smoked and made at least one quit attempt in the previous 12 months, were categorized into three groups according to the method used in their most recent quit attempt: e-cigarette only, no aid, other quitting methods (medications; programmes delivered in smoking cessation services; other unspecified methods). The primary outcome was self-reported abstinence for a period ≥ 6 months, adjusted for potential confounders. Eleven percent used e-cigarettes only, 86% no aid, 3% other quitting methods. Smoking abstinence was reported among 9% of those using no aid; 8% of e-cigarette users; 15% of those using other methods. No significant differences in abstinence were observed for e-cigarette users compared with those reporting no aid (adjusted Prevalence Ratio [aPR] = 0.81; 95%Confidence Interval (CI) = 0.58–1.14). Changing the reference group to e-cigarette users, those using other quitting methods were significantly more likely to report abstinence than e-cigarette users (aPR = 1.76; 95%CI = 1.07–2.88). One out of ten smokers who attempted to quit in 2014–2015 in Italy used e-cigarettes. E-cigarettes users were as likely to report abstinence as those using no aid, but were less likely to report abstinence than users of established quitting methods. Further studies are needed to understand the relationship between e-cigarette types used to quit and abstinence rates

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“…Die Einschätzung der Bedeutung des E-Zigaretten-Konsums variiert zwischen unterschiedlichen Ländern stark [20] …”

Section: Ad 5: Normalisierung Des Konventionellen Tabakrauchensunclassified

E-Zigaretten-Hype

Gohlke¹

2016

Kardiologe

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Evidence, Policy, and E-Cigarettes — Will England Reframe the Debate?

Cited by 76 publications

References 1 publication

Acute effects of short term use of e-cigarettes on airways physiology and respiratory symptoms in smokers with and without airways obstructive diseases and in healthy non smokers

Acute effects of short term use of e-cigarettes on airways physiology and respiratory symptoms in smokers with and without airways obstructive diseases and in healthy non smokers

Electronic cigarette use as an aid to quit smoking in the representative Italian population PASSI survey

E-Zigaretten-Hype

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