Evidence on the effect of uncontrolled diabetes mellitus on orthodontic tooth movement. A systematic review with meta-analyses in pre-clinical in- vivo research

Koletsi, Despina; Iliadi, Anna; Papageorgiou, Spyridon N.; Konrad, Daniel; Eliades, Theodore

doi:10.1016/j.archoralbio.2020.104739

Cited by 4 publications

(8 citation statements)

References 43 publications

(67 reference statements)

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“…Accumulating evidence manifested that DM increases the severity of periodontal diseases, promoting inflammatory process and impairing bone remodeling (Graves et al, 2020). Previous studies have demonstrated the proinflammatory effects of diabetes on periodontal tissues during OTM, accompanied by the manifestations of gum bleeding, tooth loosening or even loss (D'Aiuto et al, 2018; Koletsi et al, 2020). Specifically, the high level of glucose in the periodontium accelerates the production of glycation end‐products and proinflammatory cytokines, followed by severe inflammation, reduced alveolar bone formation, and increased bone resorption (Santamaria‐Jr et al, 2020; Vicente et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…During orthodontic tooth movement (OTM), orthodontic force causes aseptic inflammation, leading to bone resorption in the compression region and bone formation in the tension region. Eventually, the periodontium is reconstructed and tooth is moved (Jiang et al, 2015; Koletsi et al, 2020). Thus, well‐controlled inflammation is essential in OTM.…”

Section: Introductionmentioning

confidence: 99%

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Contribution of diabetes mellitus to periodontal inflammation during orthodontic tooth movement

et al. 2022

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ObjectiveThis study aims to clarify the effects of diabetes mellitus (DM) on inflammatory profile during orthodontic tooth movement (OTM) and explore potential mechanisms.MethodsOTM models were established in healthy (Ctrl) and DM rats for 0, 3, 7 or 14 days. The tooth movement distance and bone structural parameters were analyzed through micro‐CT. The bone resorption activity and periodontal inflammation status were evaluated through histological staining. RNA sequencing was performed to detect differentially expressed genes in force loading‐treated periodontal ligament fibroblasts (PDLFs) with or without high glucose. The differential expression of inflammatory genes associated with NOD‐like receptor family pyrin domain containing 3 (NLRP3) between groups was tested in vitro and in vivo.ResultsDM caused remarkable reduction of alveolar bone height and density around the moved tooth, corresponding with the higher bone resorption activity and inflammatory scores of DM group. For force loading‐treated PDLFs, high glucose induced the activation of inflammatory pathways, including NLRP3. Elevated expression of NLRP3 and cascade molecules (Caspase‐1, GSDMD, and IL‐1β) were validated by RT‐qPCR, Western blot, and immunohistochemistry staining.ConclusionsDM alters the inflammatory status of periodontium and affects tissue reconstruction during OTM. NLRP3 inflammasome may involve in diabetes‐induced periodontal changes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Contribution of diabetes mellitus to periodontal inflammation during orthodontic tooth movement

et al. 2022

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“…At present, studies of tooth movement have focused on tissue remodeling of horizontal tooth movement caused by orthodontic force ( 6 ). The horizontal movement during orthodontic treatment is affected by the traction force of the orthodontic device, and the mechanical stress or traction generated during orthodontic tooth movement also can cause tissue damage and triggers an inflammatory response ( 7 ), which cannot reflect the intrinsic physiological mechanism of tooth movement. The study of tooth axial movement is mainly related to tooth eruption, which is defined as the axial movement of the tooth from its site of development in the alveolar bone to its functional position in the oral cavity ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Remodeling of the periodontal ligament and alveolar bone during axial tooth movement in mice with type 1 diabetes

Zheng

et al. 2023

Front. Endocrinol.

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ObjectivesTo observe the elongation of the axial tooth movement in the unopposed rodent molar model with type 1 diabetes mellitus and explore the pathological changes of periodontal ligament and alveolar bone, and their correlation with tooth axial movement.MethodsThe 80 C57BL/6J mice were randomly divided into the streptozotocin(STZ)-injected group (n = 50) and the control group (n = 30). Mice in the streptozotocin(STZ)-injected group were injected intraperitoneal with streptozotocin (STZ), and mice in the control group were given intraperitoneal injection of equal doses of sodium citrate buffer. Thirty mice were randomly selected from the successful models as the T1DM group. The right maxillary molar teeth of mice were extracted under anesthesia, and allowed mandibular molars to super-erupt. Mice were sacrificed at 0, 3, 6,9, and 12 days. Tooth elongation and bone mineral density (BMD) were evaluated by micro-CT analysis(0,and 12 days mice). Conventional HE staining, Masson staining and TRAP staining were used to observe the changes in periodontal tissue(0, 3, 6, 9, and 12 days mice). The expression differences of SPARC, FGF9, BMP4, NOGGIN, and type I collagen were analyzed by RT-qPCR.ResultsAfter 12 days of tooth extraction, our data showed significant super-eruption of mandibular mouse molars of the two groups. The amount of molar super-eruption in the T1DM group was 0.055mm( ± 0.014mm), and in the control group was 0.157( ± 0.017mm). The elongation of the T1DM mice was less than that of the control mice(P<0.001). It was observed that the osteoclasts and BMD increased gradually in both groups over time. Compared with the control group, the collagen arrangement was more disordered, the number of osteoclasts was higher (P<0.05), and the increase of bone mineral density was lower(2.180 ± 0.007g/cm3 vs. 2.204 ± 0.006g/cm3, P<0.001) in the T1DM group. The relative expression of SPARC, FGF9, BMP4, and type I collagen in the two groups increased with the extension of tooth extraction time while NOGGIN decreased. The relative expression of all of SPARC, FGF9, BMP4, and type I collagen in the T1DM group were significantly lower, and the expression of NOGGIN was higher than that in the control group (P<0.05).ConclusionThe axial tooth movement was inhibited in type 1 diabetic mice. The result may be associated with the changes of periodontal ligament osteoclastogenic effects and alveolar bone remodeling regulated by the extracellular matrix and osteogenesis-related factors.

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“…The process of orthodontic tooth movement is initiated by the application of orthodontic force, which results in aseptic inflammation. This inflammation induces bone resorption in the compressive area and bone formation in the tensile area, leading to periodontium remodeling and tooth displacement [1,2]. However, excessive periodontal inflammation inhibits osteogenesis and accelerates the formation of osteoclasts, breaking the balance of bone remodeling and resulting in unfavorable outcomes of orthodontic treatment, such as undesired patterns of tooth movement or dental root resorption [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Hyperglycemia could damage multiple tissues and systems, such as the cardiovascular system, kidneys, and oral tissues [7][8][9]. Periodontitis, a common complication of type 2 diabetes, is characterized by the destruction of the tooth supporting tissues, which could lead to misalignment or displacement of teeth [2,10]. Hence, patients with type 2 diabetes may be seeking treatment for dental complications of type 2 diabetes, like periodontitis-related misaligned teeth [10].…”

Section: Introductionmentioning

confidence: 99%

The onset of adenosine monophosphate‐activated protein kinase activity on orthodontic tooth movement in rats with type 2 diabetes

Huang,

Li,

Chen

et al. 2023

European J Oral Sciences

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Adenosine monophosphate‐activated protein kinase (AMPK) plays pivotal roles in metabolic diseases including type 2 diabetes. However, the specific role of AMPK for orthodontic tooth movement in type 2 diabetes is unclear. In this study, a diabetic rat model was established through dietary manipulation and streptozocin injection. Examinations were conducted to select qualified type 2 diabetic rats. Then, an orthodontic device was applied to these rats for 0, 3, 7, or 14 days. The distance of orthodontic tooth movement and parameters of alveolar bone were analyzed by micro‐computed tomography. Periodontal osteoclastic activity, inflammatory status, and AMPK activity were measured via histological analyses. Next, we repeated the establishment of diabetic rats to investigate whether change of AMPK activity was associated with orthodontic tooth movement under type 2 diabetes. The results showed that diabetic rats exhibited an exacerbated alveolar bone resorption, overactive inflammation, and decreased periodontal AMPK activity during orthodontic tooth movement. Injection of the AMPK agonist alleviated type 2 diabetes‐induced periodontal inflammation and alveolar bone resorption, thus normalizing distance of orthodontic tooth movement. Our study indicates that type 2 diabetes decreases periodontal AMPK activity, leading to excessive inflammation elevating osteoclast formation and alveolar bone resorption, which could be reversed by AMPK activation.

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Evidence on the effect of uncontrolled diabetes mellitus on orthodontic tooth movement. A systematic review with meta-analyses in pre-clinical in- vivo research

Cited by 4 publications

References 43 publications

Contribution of diabetes mellitus to periodontal inflammation during orthodontic tooth movement

Contribution of diabetes mellitus to periodontal inflammation during orthodontic tooth movement

Remodeling of the periodontal ligament and alveolar bone during axial tooth movement in mice with type 1 diabetes

The onset of adenosine monophosphate‐activated protein kinase activity on orthodontic tooth movement in rats with type 2 diabetes

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