Evidence of White Matter Pathology in Bipolar Disorder Adolescents Experiencing Their First Episode of Mania: A Diffusion Tensor Imaging Study

Adler, Caleb M.; Adams, John S.; DelBello, Melissa P.; Holland, Scott K.; Schmithorst, Vince; Levine, Ari; Jarvis, Kelly; Strakowski, Stephen M.

doi:10.1176/appi.ajp.163.2.322

Cited by 198 publications

(158 citation statements)

References 15 publications

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“…One explanation is that lithium may have different generalized effects in healthy and diseased brains. This global white matter increase is also of interest considering recent evidence for white matter pathology as an early marker for bipolar disorder [16] and lithium's effect of causing formation of multiple axons in rat hippocampus neurons through inhibition of glycogen synthase kinase-3β [17].…”

Section: Discussionmentioning

confidence: 99%

Prefrontal gray matter increases in healthy individuals after lithium treatment: A voxel-based morphometry study

Monkul

Matsuo

Nicoletti

et al. 2007

Neuroscience Letters

115

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The objective of this study was to test the hypothesis that 4 weeks of lithium administration would be associated with changes in brain gray and white matter volumes in healthy individuals. Thirteen right-handed healthy volunteers (6 females, mean age = 25.9 ± 10.0 y) were studied. 3D SPGR MRIs (TR = 25ms, TE = 5ms, slice-thickness = 1.5mm) were acquired using a 1.5 T GE Signa Imaging System, at baseline and after 4 weeks of lithium administration at therapeutically relevant doses. Optimized voxel based morphometry (VBM) analyses were conducted. Left and right dorsolateral prefrontal cortex and left anterior cingulate gray matter volumes increased significantly following lithium administration. Total white matter volume was increased, whereas total brain volume and total gray matter volume were not significantly changed following 4 weeks of lithium. Lithium treatment resulted in prefrontal regional gray matter volume increases in healthy volunteers, as well as increases in total white matter volume. Whether these changes are mediated by neurotrophic/ neuroprotective or osmotic effects remains unknown.

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Section: Discussionmentioning

confidence: 99%

Prefrontal gray matter increases in healthy individuals after lithium treatment: A voxel-based morphometry study

Monkul

Matsuo

Nicoletti

et al. 2007

Neuroscience Letters

115

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“…25 Kanaan et al 59 have underlined the controversial use of ROI approaches because of the great variability of WM tracts and the lack of anatomical landmarks to draw them. This methodological shortcoming might explain the rather contradictory findings of DTI studies in BP, reporting predominantly increased ADC or decreased FA in frontal WM [19][20][21] with one study reporting increased as well as decreased FA in different ROIs. 22 The present findings have to be interpreted in light of some limitations.…”

Section: Diffusion Tensor Tractography In Bipolar Patients J Houenou mentioning

confidence: 99%

“…[19][20][21][22] As the amount of FA has been shown to be an indirect measures of the directionality and coherence of fiber tracts, 23,24 DTI studies in BP suggest a loss of coherence in frontal WM bundles. However, these studies have investigated predefined and limited regions of interest (ROIs), representing only a part of a specific WM bundles and might thus be susceptible to overlook subtle differences between study groups.…”

Section: Introductionmentioning

confidence: 99%

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

et al. 2007

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Bipolar disorder has been associated with anatomical as well as functional abnormalities in a brain network that mediates normal and impaired emotion regulation. Previous brain imaging studies have highlighted the subgenual cingulate (SC) and the amygdalo-hippocampal (AH) complex as core regions of this network. Thus we investigated white matter (WM) fiber tracts between the SC and the AH region, the uncinate fasciculus, as well as between two control regions (pons and cerebellum), using diffusion tensor imaging tractography in 16 euthymic bipolar patients (BP) and 16 sex-, age-and handedness-matched controls. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the reconstructed fiber bundle and the number of virtual reconstructed fibers were compared between groups. The tractography results revealed a significantly increased number of reconstructed fibers between the left SC and left AH in BP as compared to healthy controls. FA and ADC of the reconstructed fiber tract did not differ significantly between the groups. Furthermore, no significant group differences were observed neither for reconstructed fiber tracts between the right SC and right AH nor between the control regions. The present results suggest an altered WM pathway between the left SC and AH region and thus extend previous findings of anatomical and functional modifications in these structures in BP.

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“…5,14 Severe white matter abnormalities in patients with bipolar disorder have been usually investigated using magnetic resonance imaging (MRI) studies of white matter volumes and hyperintensities, magnetization transfer studies and MRI spectroscopy. 11,[14][15][16] More recently, diffusion tensor imaging (DTI), an MRI technique that explores the microstructural integrity of white matter, 17 has been applied in studies of bipolar disorder. Overall, the few previous DTI studies reported reduced fractional anisotropy and increased radial diffusion in the frontal and prefrontal lobes, internal capsule, corpus callosum and uncinate fasciculus of patients with bipolar disorder.…”

Section: Introductionmentioning

confidence: 99%

Combined analysis of grey matter voxel-based morphometry and white matter tract-based spatial statistics in late-life bipolar disorder

Haller

Xekardaki

Delaloye

et al. 2011

jpn

109

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Previous magnetic resonance imaging (MRI) studies in young patients with bipolar disorder indicated the presence of grey matter concentration changes as well as microstructural alterations in white matter in various neocortical areas and the corpus callosum. Whether these structural changes are also present in elderly patients with bipolar disorder with long-lasting clinical evolution remains unclear

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Evidence of White Matter Pathology in Bipolar Disorder Adolescents Experiencing Their First Episode of Mania: A Diffusion Tensor Imaging Study

Cited by 198 publications

References 15 publications

Prefrontal gray matter increases in healthy individuals after lithium treatment: A voxel-based morphometry study

Prefrontal gray matter increases in healthy individuals after lithium treatment: A voxel-based morphometry study

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

Combined analysis of grey matter voxel-based morphometry and white matter tract-based spatial statistics in late-life bipolar disorder

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