Evidence of the protective effect of l-arginine and vitamin D against monosodium glutamate-induced liver and kidney dysfunction in rats

Elbassuoni, Eman; Ragy, Merhan; Ahmed, Sabreen Mahmoud

doi:10.1016/j.biopha.2018.09.093

Cited by 49 publications

(43 citation statements)

References 45 publications

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“…Hemorrhagic areas were reported in different organs of rats treated with MSG was in the same studies reported Extensive areas of hemorrhage among liver parenchyma of MSG orally treated rats (36). Also with a study reported Hemorrhages in the pancreatic islets (37) .…”

Section: Discussionmentioning

confidence: 79%

Obesogenic and histopathological effect of monosodium glutamate on the adrenal gland of maternal and postnatal albino rats

Abdelbaki

Abobakr

Abdallah

et al. 2021

Journal of Modern Research

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Monosodium glutamate (MSG) is a flavoring food additive that"s found in many foods like chips, and fast foods. The aim of this study was to demonstrate the injurious effects of MSG on the adrenal glands of the female albino rats and its potentiality to cross the placental barrier carrying its injurious effects to their pups. Twenty-five female albino rats weighing about (200) g were mated then separated into two groups. The control group (10 rats),and MSG-treated Group(15 rats) received 10g/kg MSG orally, dissolved in water at a concentration of 10 g/100 ml, starting on day 7 to 20 day of gestation.A day after delivery, animals were weighed, blood samples collected then sacrificed, and the adrenals were collected and examined by the light and electron microscope. Statistically, there was a significant increase in the body weight and decrease in adrenal weight of MSG-treated mothers and their pups, as well as a decrease in the corticosterone level in MSG-treated mothers. Histologically, MSG-treated mothers and pups showed many degenerative changes, with thinning of the capsule that was confirmed by Masson trichrome stain, a abnormal structure of Zona Golmeruloza and Zona Fasciculata, and areas of shedding and blood vessels were noticed. Shrunken nuclei and degenerated mitochondria with disrupted cristae and penetration of the lipid droplets to form "myelin-like" structures were noticed by E/M examination. The study concluded that MSG had an unwholesome effect on the structure of the adrenal tissue of both pregnant rats and their pups.

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Section: Discussionmentioning

confidence: 79%

Obesogenic and histopathological effect of monosodium glutamate on the adrenal gland of maternal and postnatal albino rats

Abdelbaki

Abobakr

Abdallah

et al. 2021

Journal of Modern Research

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“…There are many hypotheses linking kidney and liver diseases with dietary triggers over the years, earlier studies indicated that MSG could be a cause of liver damage because the liver is responsible for removing foreign elements and toxins in the food [30]. Also, histological changes were observed, Bowman's area expanded, in addition to decrease levels of urea and creatinine in the blood, which indicate a decrease in kidney function, when administering doses ranging between (3-6 mg MSG / g of bodyweight) for a period of 45 days to experimental animals [31,32].…”

Section: The Effect Of Msg On Kidney Liver and Heartmentioning

confidence: 98%

The Effect of Food Additives (Monosodium Glutamate - MSG) On Human Health - A Critical Review

Al-Agili

2020

JAUC

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According to the famous saying of the medieval physician Paracelsus, "There is no substance without poison. Only the dose determines the extent of the toxic effect." Here, the effect of monosodium glutamate (MSG) on human health and the risks to the health of its frequent use in the short term was addressed and the long term was evaluated according to the studies of several researchers specializing in this regard. Monosodium glutamate (MSG) is known as one of the most popular food additives that classified as a flavor enhancer. Parts of the evidence were reviewed from the literature explaining its effect on immune system cells in addition to metabolic disorders by exposing individuals to obesity and what is known as metabolic syndrome, as well as reviewing a lot of evidence indicating the effect of MSG intake on the health of the kidney, liver and other parts of the body through Practical application to laboratory rats and clinical studies in humans.

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“…On the other hand, the molecular mechanisms behind the protecting actions of VD in the kidney can be more related to the decrease of oxidative stress and a significant increase in the total antioxidant capacity of the renal tissue (Elbassuoni et al 2018, Finch et al 2012. The VD receptor (VDR) has potent anti-inflammatory activities, and low expression of VDR is associated with renal injury activity (Sun et al 2019).…”

Section: Msg Msg-s Vd Msg-e Ns Msg-e Vdmentioning

confidence: 99%

Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamate

Zanuzo

Guareschi

Detogni

et al. 2020

An. Acad. Bras. Ciênc.

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Evidence of the protective effect of l-arginine and vitamin D against monosodium glutamate-induced liver and kidney dysfunction in rats

Cited by 49 publications

References 45 publications

Obesogenic and histopathological effect of monosodium glutamate on the adrenal gland of maternal and postnatal albino rats

Obesogenic and histopathological effect of monosodium glutamate on the adrenal gland of maternal and postnatal albino rats

The Effect of Food Additives (Monosodium Glutamate - MSG) On Human Health - A Critical Review

Physical exercise associated with vitamin D chronic supplementation reduces kidney injury induced by monosodium glutamate

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