Evidence of Similar Idiotypic Determinants on Different Rheumatoid Factor Populations

Førre, Ø.; Dobloug, Jan H.; Michaelsen, T. E.; Natvig, J. B.

doi:10.1111/j.1365-3083.1979.tb02732.x

Cited by 88 publications

(31 citation statements)

References 23 publications

(43 reference statements)

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“…Typical association constants for IgM or IgG, RFs average between 1 X 104, 5 X 105 L/M (23,24), which is 10-to 100-fold less than the affinities ofheteroantibodies produced following exogenous immunization. In addition, we (17) and others (25), have observed the major RCRI in high frequency in RA both at the cellular and serologic level employing polyclonal antimajor RCRI antibodies (17,18).…”

Section: Discussionmentioning

confidence: 60%

Monomeric (7S) IgM found in the serum of rheumatoid arthritis patients share idiotypes with pentameric (19S) monoclonal rheumatoid factors.

Bonagura¹,

Mendez²,

Agostino³

et al. 1987

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 60%

Monomeric (7S) IgM found in the serum of rheumatoid arthritis patients share idiotypes with pentameric (19S) monoclonal rheumatoid factors.

Bonagura¹,

Mendez²,

Agostino³

et al. 1987

J. Clin. Invest.

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“…(24). They reported that although both Wa-and Po-like CRI patterns were present among the polyclonal RF of RA patients, additional CRI were also found.…”

Section: Introductionmentioning

confidence: 99%

The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germ line genes.

et al. 1990

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Structural studies of human monoclonal rheumatoid factors (RF) derived from patients with monoclonal gammapathies have revealed a restriction in the usage of heavy and light chain variable regions. These studies have suggested that germline genes with little if any somatic mutation can generate RF specificity. However, there is no information presently available regarding the primary structure and genetic origin of RF in rheumatoid arthritis. In this study, we have isolated and sequenced the VH regions of six monoclonal RF derived from the synovial membranes of two patients with rheumatoid arthritis and one with the juvenile polyarticular form of the disease. We found the same VH families as previously reported among monoclonal paraproteins with RF activity. However, our sample was diverse regarding the VH, DH, and JH gene segments used. Among VHI RF there was conservation in the length of CDRIII as well as restriction in the amino acid generated at the V-D junction, as opposed to VHIII RF and non-RF VHI molecules that are highly heterogeneous in these two aspects. We also found that different JH gene segments may contribute to RF specificity. The VH, DH, and JH elements of one RF in our study all had clearly identifiable germline counterparts. This RF displays a nearly germline configuration throughout its entire heavy chain and represents another example of an autoantibody encoded by one of the VH gene segments from the preimmune fetal repertoire. (J. Clin. Invest. 1990Invest. . 86:1320Invest. -1328

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“…However, while the Wa and Po CRI have been detected in polyclonal rheumatoid factors present in the sera of patients with rheumatoid arthritis (21)(22)(23)(24), the amounts of these CRI are quite modest. Extensive serologic analyses of polyclonal rheumatoid factors from patients with rheumatoid arthritis show them to be diverse, and that the common idiotypes ofthe mixed cryoglobulin rheumatoid factors account for only a minor population (25,26).…”

Section: Introductionmentioning

confidence: 99%

Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross-reactive idiotypes.

Victor¹,

Randen²,

Thompson³

et al. 1991

J. Clin. Invest.

104

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To better understand the structural basis for rheumatoid factor activity, the nucleotide sequence of the light chain variable regions of nine human monospecific IgM rheumatoid factors were analyzed. Rheumatoid factors were isolated from three patients with rheumatoid arthritis, a patient with systemic lupus erythematosus, and a normal individual. The VL gene segments used by these rheumatoid factors are not as restricted as previous work on mixed cryoglobulin rheumatoid factors had suggested. Each of the different VK families is represented and there are two examples where a V, gene segment is used. Molecules with structures similar to those of the Wa and Po CRI, characteristic of mixed cryoglobulin rheumatoid factors, are not common among these rheumatoid factors isolated from patients with rheumatoid arthritis. While there are clear examples of rheumatoid factors that are direct copies of germline genes, most of the sequence data suggest that the processes of antigenic selection and somatic mutation contribute significantly to the generation of monospecific rheumatoid factors in patients with autoimmune disease. (J. Clin. Invest. 1991.

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Evidence of Similar Idiotypic Determinants on Different Rheumatoid Factor Populations

Abstract: Strong idiotypic antigens were detected both in monoclonal and polyclonal rheumatoid factors (RF) by applying idiotype‐specific antisera. Shared idiotypic antigens were found between some polyclonal and monoclonal RF as well as between certain IgG and IgM RF.

Cited by 88 publications

References 23 publications

Monomeric (7S) IgM found in the serum of rheumatoid arthritis patients share idiotypes with pentameric (19S) monoclonal rheumatoid factors.

Monomeric (7S) IgM found in the serum of rheumatoid arthritis patients share idiotypes with pentameric (19S) monoclonal rheumatoid factors.

Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross-reactive idiotypes.

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