Evidence of shared risk for Alzheimer’s disease and Parkinson’s disease using family history

Rosén, Anne; Steenland, N. Kyle; Hanfelt, John; Factor, Stewart A.; Lah, James J.; Levey, Aĺlan I.

doi:10.1007/s10048-007-0100-6

Cited by 19 publications

(21 citation statements)

References 38 publications

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“…10 In our study, a firstdegree family history of PD was more common in DLB compared with AD and normal control subjects. It is not known whether these relatives also had accompanying dementia.…”

Section: Resultsmentioning

confidence: 43%

“…The results likely reflect the mixed synuclein/AD pathology seen in most DLB cases. The presence of one or more APOE e4 alleles is a well-known risk factor for AD 10 but it is unrelated to PD. 19 Studies indicate that the risk of PD, 19 and possibly AD, 20 is reduced among coffee and caffeine users.…”

Section: Resultsmentioning

confidence: 99%

“…We confined our risk factor assessment to 19 demographic, genetic, or disease characteristics associated with DLB, AD, or PD and for which data were available from the studies: age, 5 sex, 5 family history of dementia 2,7,8 or PD, 9,10 APOE e4 status (any e4 alleles vs none), 11,12 history of anxiety 13 or depression, 14,15 smoking (ever vs never in lifetime), 16,17 alcohol (ever vs never) 18,19 and caffeine consumption (ever vs never), 20,21 cancer (excluding nonmelanoma skin cancer), 22,23 diabetes mellitus, 24,25 education (9 or more years vs less than 9), 26,27 head injury, 28,29 number of children in men (more than one vs zero or one child), 30 occupation as a physician (vs all other occupations), 27 oophorectomy (uni-or bilateral, with or without hysterectomy), 31,32 oophorectomy at or before age 45, 32,33 and stroke. 34,35 Data definitions are in table e-1 on the Neurology ® Web site at www.neurology.org.…”

Section: Conclusion: Dlb Risk Factors Are An Amalgam Of Those For Ad mentioning

confidence: 99%

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Risk factors for dementia with Lewy bodies

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Ahlskog³

et al. 2013

Neurology

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114

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Objective: To determine the risk factors associated with dementia with Lewy bodies (DLB). Methods:We identified 147 subjects with DLB and sampled 2 sex-and age-matched cognitively normal control subjects for each case. We also identified an unmatched comparison group of 236 subjects with Alzheimer disease (AD). We evaluated 19 candidate risk factors in the study cohort.Results: Compared with controls, subjects with DLB were more likely to have a history of anxiety (odds ratio; 95% confidence interval) (7.4; 3.5-16; p , 0.0001), depression (6.0; 3.7-9.5; p , 0.0001), stroke (2.8; 1.3-6.3; p 5 0.01), a family history of Parkinson disease (PD) (4.6; 2.5-8.6; p , 0.0001), and carry APOE e4 alleles (2.2; 1.5-3.3; p , 0.0001), but less likely to have had cancer (0.44; 0.27-0.70; p 5 0.0006) or use caffeine (0.29; 0.14-0.57; p , 0.0001) with a similar trend for alcohol (0.65; 0.42-1.0; p 5 0.0501). Compared with subjects with AD, subjects with DLB were younger (72.5 vs 74.9 years, p 5 0.021) and more likely to be male (odds ratio; 95% confidence interval) (5.3; 3.3-8.5; p , 0.0001), have a history of depression (4.3; 2.4-7.5; p , 0.0001), be more educated (2.5; 1.1-5.6; p 5 0.031), have a positive family history of PD (5.0; 2.4-10; p , 0.0001), have no APOE e4 alleles (0.61; 0.40-0.93; p 5 0.02), and to have had an oophorectomy before age 45 years (7.6; 1.5-39; p 5 0.015).Conclusion: DLB risk factors are an amalgam of those for AD and PD. Smoking and education, which have opposing risk effects on AD and PD, are not risk factors for DLB; however, depression and low caffeine intake, both risk factors for AD and PD, increase risk of DLB more strongly than in either. Neurology Dementia with Lewy bodies (DLB) is the second most common dementia syndrome, representing 10% to 15% of cases. Knowledge of risk factors for DLB may provide clues to the underlying pathophysiology, yet the only known risk factors are advanced age, male sex, 1 and a family history of dementia.2 We compared the frequency of Alzheimer disease (AD) and Parkinson disease (PD) risk factors among subjects with DLB to age-and sex-matched controls, and to subjects with AD. Risk factors driving amyloid pathology should be present in AD and, to a lesser extent, in DLB. In contrast, risk factors driving Lewy body pathology should be found in DLB, but not AD or control subjects.METHODS Standard protocol approvals, registrations, and patient consents. All protocols were approved by our institutional review board, and consent was obtained from subjects and carers.Subjects. Subjects were recruited into 3 longitudinal studies at Mayo Clinic, Rochester, MN. The Alzheimer Disease Patient Registry (1985)(1986)(1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004) 3 and Alzheimer Disease Research Center Study (1999-present) recruited patients with incident dementia and age-and sex-matched controls. The Mayo Clinic Study of Aging (2004-present) follows all community-dwelling persons aged 70 to 89 years.

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Section: Resultsmentioning

confidence: 43%

Section: Resultsmentioning

confidence: 99%

Section: Conclusion: Dlb Risk Factors Are An Amalgam Of Those For Ad mentioning

confidence: 99%

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Risk factors for dementia with Lewy bodies

Boot¹,

Orr²,

Ahlskog³

et al. 2013

Neurology

140

114

View full text Add to dashboard Cite

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“…Another hospital-based study found no increased risk of Alzheimer's disease in relatives of PD cases without dementia compared to controls [580]. Yet another hospital-based study reported higher frequency of family history of PD in PD cases with family history of Alzheimer's disease compared to PD cases without family history of Alzheimer's disease, corresponding to an OR of 1.7 (95% CI 1.1-2.6) [581].…”

Section: Dementiamentioning

confidence: 96%

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

et al. 2011

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“…Of the 16 studies included, 7 investigated the coaggregation of AD and PD as their primary aim [7,16,17,18,19,20,21], whereas 9 studies investigated the coaggregation of AD and PD as one of many aims [6,14,15,22,23,24,25,26,27]. The relative risk estimates from the studies included in the meta-analysis could be divided into 4 groups: (1) reconstructed cohort studies estimating HR with AD or dementia as the outcome [16,17,18,19,20] (n = 5; table 2); (2) case-control studies estimating OR with AD or dementia as the outcome [6,7,21,22,25,26,27] (n = 7; table 2); (3) reconstructed cohort studies estimating OR with PD or parkinsonism as the outcome [23] (n = 1), and (4) case-control studies estimating OR with PD or parkinsonism as the outcome [21,24] (n = 2).…”

Section: Resultsmentioning

confidence: 99%

Familial Coaggregation of Alzheimer's Disease and Parkinson's Disease: Systematic Review and Meta-Analysis

et al. 2013

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Background: Familial aggregation has been shown for Alzheimer's disease (AD) and Parkinson's disease (PD) separately, and it has been hypothesized that these diseases also coaggregate in families. Methods: The authors investigated familial coaggregation of AD and PD by conducting a systematic review and meta-analysis. PubMed was searched for relevant studies published through the end of October 2012. Three independent investigators screened publications and extracted data. Relative risk estimates of AD risk associated with family history of PD or parkinsonism, or PD risk associated with family history of AD or dementia, were summarized into metaestimates using random effects models. Heterogeneity and publication bias were tested using Higgins' and Egger's tests, respectively. Results: We included 16 studies in the review, with 14 included in any meta-analysis. AD risk associated with family history of PD yielded a summary hazard ratio of 1.18 (95% CI: 1.00-1.39) based on 5 reconstructed cohort studies and a summary odds ratio (OR) of 1.40 (95% CI: 0.92-2.12) based on 7 case-control studies. PD risk associated with family history of AD yielded a summary OR of 0.75 (95% CI: 0.49-1.16) based on 3 studies. There was no significant heterogeneity among studies, nor significant publication bias. Conclusions: There may be familial coaggregation of AD and PD, although the association was modest and only apparent when studying AD risk associated with family history of PD.

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Evidence of shared risk for Alzheimer’s disease and Parkinson’s disease using family history

Cited by 19 publications

References 38 publications

Risk factors for dementia with Lewy bodies

Risk factors for dementia with Lewy bodies

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

Familial Coaggregation of Alzheimer's Disease and Parkinson's Disease: Systematic Review and Meta-Analysis

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