Evidence of recombinant ecotropic provirus integration in thymic lymphomas induced by direct or indirect radiation effects

Genetics of susceptibility to radiation-induced lymphomas, leukemias and lung tumors studied in recombinant congenic strains

“…In contrast with the virally-induced lymphomas in mice (for review see Jonkers and Berns, 1996), the nature of somatic genetic changes leading to radiation-induced lymphomas has not been clarified. They do not appear to be associated with a viral etiology (e.g., Janowski et al, 1986;Okumoto et al, 1990), although possible involvement of ecotropic viruses has been reported (Baylac-Kalabokias et al, 1989). A spectrum of somatic mutations including deletions or abnormal methylation has been described for radiation-induced lymphomas (Malumbres et al, 1997) and myeloid leukemias (Alexander et al, 1995;Rithidech et al, 1995).…”