Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer

Lombardo, Domenico; Munaò, Gianmarco; Calandra, Pietro; Pasqua, Luigi; Caccamo, Maria Teresa

doi:10.1039/c9cp02195g

Cited by 37 publications

(29 citation statements)

References 50 publications

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“…These aggregates can be detected through the measurement of a discontinuity in some properties of the system (such as the osmotic pressure, surface tension, turbidity, equivalent conductivity) at a specific concentration (critical micelle concentration-CMC) and at a given temperature (critical micelle temperature-CMT) [16,17]. It is worth mentioning that a number of investigations have evidenced the presence of a premicellar aggregation process characterized by the presence of aggregates at concentrations significantly lower than the CMC [20][21][22].…”

Section: Traditional Amphiphile Building Blocks: Micelles Vesicles mentioning

confidence: 99%

Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications

et al. 2020

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In this paper, we survey recent advances in the self-assembly processes of novel functional platforms for nanomaterials and biomaterials applications. We provide an organized overview, by analyzing the main factors that influence the formation of organic nanostructured systems, while putting into evidence the main challenges, limitations and emerging approaches in the various fields of nanotechology and biotechnology. We outline how the building blocks properties, the mutual and cooperative interactions, as well as the initial spatial configuration (and environment conditions) play a fundamental role in the construction of efficient nanostructured materials with desired functional properties. The insertion of functional endgroups (such as polymers, peptides or DNA) within the nanostructured units has enormously increased the complexity of morphologies and functions that can be designed in the fabrication of bio-inspired materials capable of mimicking biological activity. However, unwanted or uncontrollable effects originating from unexpected thermodynamic perturbations or complex cooperative interactions interfere at the molecular level with the designed assembly process. Correction and harmonization of unwanted processes is one of the major challenges of the next decades and requires a deeper knowledge and understanding of the key factors that drive the formation of nanomaterials. Self-assembly of nanomaterials still remains a central topic of current research located at the interface between material science and engineering, biotechnology and nanomedicine, and it will continue to stimulate the renewed interest of biologist, physicists and materials engineers by combining the principles of molecular self-assembly with the concept of supramolecular chemistry.

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Section: Traditional Amphiphile Building Blocks: Micelles Vesicles mentioning

confidence: 99%

Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications

et al. 2020

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“…In this case, the micelles hydrophobic core creates a microenvironment for the incorporation of the hydrophobic CUR, while the hydrophilic shell ensures their water solubility. Particularly interesting is the use of PEG for the hydrophilic polymer block, as it creates a local surface concentration of highly hydrated polymer brushes [189][190][191] that sterically inhibit the interactions with plasma proteins (or cells), thus reducing the nanocarrier uptake process by mononuclear phagocytic systems (MPS). Moreover, the surface coatings with PEG blocks have been shown to increase colloidal stability, solubility as well as to improve polymeric nanoparticle diffusion in brain tissues [191,192].…”

Section: Polymer-based Nanocarriers: Polymer Nanoparticles and Micellesmentioning

confidence: 99%

Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

Salehi

Calina

Docea

et al. 2020

JCM

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134

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The brain is the body’s control center, so when a disease affects it, the outcomes are devastating. Alzheimer’s and Parkinson’s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β-binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, and synaptogenesis promotion. The therapeutic limitation of curcumin is its bioavailability, and to address this problem, new nanoformulations are being developed. The present review aims to summarize the general bioactivity of curcumin in neurological disorders, how functional molecules are extracted, and the different types of nanoformulations available.

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“…58 In many amphiphilic systems the subtle combination of the soft interactions at the nanoscale and at a molecular level can generate also soft nanostructured materials with relatively complex morphologies and characterised by a multi-stage organization process. In this mechanism a wide variety of molecules can be involved: dendrimers and vescicles, 59 block copolimers 60 and amphiphiles whose organisation can give supra-amphiphiles 61 with the overall result to obtain biomaterials through molecular self-assembly 62 and complex matter. 63 Those nano-structures present novel and complex structural, morphological 64 and dynamic behaviour that can be exploited for specific (supra-)molecular functions, like synthesis of zeolites 65 formation of peptides and proteins for nanotechnological applications 66 including the preparation of protein fibres, 67 conductive fluids with novel properties of conductivity 68 and inorganic metal-semiconductor nanoparticles with novel optical properties.…”

Section: Supra-orderingmentioning

confidence: 99%

Amphiphiles-metals interactions for applications in modern technologies: recent developments and future perspectives

Maiuolo¹,

Calandra²,

Lombardo³

et al. 2020

Rev.Roum.Chim.

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Amphiphiles play a pivotal role in the area of self-assembled structures and interesting additional features can be obtained if metal ions are involved. In this ambit, the development of smart materials benefits from the availability of stimuli-responsive supramolecular amphiphile assemblies where the disassembly back-processes has an inherently basic role providing reversible switching particularly useful in novel approaches and applications. In this tutorial review the basic concepts on self-assembly of traditional and novel amphiphilic molecules with metals are summarized and the more recent concepts of supramolecular assembly are presented. The aim of this contribution is to furnish to the reader a panoramic view of this exciting problematic clarifying what is meant with the concept of complexity and how the rich world of amphiphilic molecules is employed with metals for obtaining complex nanostructure-based systems with novel characteristics for applications in nanotechnology.

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Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer

Abstract: The decrease in the PEO chain hydration favours the increase in the PDMS–PEO micelle aggregation number with the increase in temperature.

Cited by 37 publications

References 50 publications

Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications

Self-Assembly of Organic Nanomaterials and Biomaterials: The Bottom-Up Approach for Functional Nanostructures Formation and Advanced Applications

Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

Amphiphiles-metals interactions for applications in modern technologies: recent developments and future perspectives

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