Evidence of osteolathyrism among patients suffering from neurolathyrism in Bangladesh

Haque, Abedul; Hossain, M; Lambein, Fernand; Bell, E. A.

doi:10.1002/(sici)(1997)5:1<43::aid-nt7>3.0.co;2-m

Cited by 27 publications

(9 citation statements)

References 16 publications

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“…6 Enzymatic crosslinks occur between adjacent lysine or hydroxylysine residues that have been deaminated by the enzyme lysyl oxidase (LOX) resulting in a reactive aldehyde. 7 Osteolathyrism, a bone disease characterized by bone pain and skeletal deformities, 8 is caused by a reduction in the quantity of enzymatically crosslinked collagen due to dietary intake of toxins (lathyrogens) present in seeds from the Lathyrus genus, which block crosslink synthesis. 9 The sweet pea (Lathyrus odoratus) contains b-aminopropionitrile (BAPN), 10 which irreversibly binds to the LOX active site, 11 and is a commonly used lathyrogen to experimentally replicate osteolathyrism.…”

Section: Introductionmentioning

confidence: 99%

Exercise prevents β-aminopropionitrile-induced morphological changes to type I collagen in murine bone

Hammond¹,

Wallace²

2015

BoneKEy Reports

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This study evaluated the effects of reduced enzymatic crosslinking, exercise and the ability of exercise to prevent the deleterious impact of reduced crosslinking on collagen D-spacing. Eight-week-old female mice were divided into four weight-matched groups receiving daily injections of either phosphate-buffered saline (PBS) or 300 mg kg À 1 b-aminopropionitrile (BAPN) while undergoing normal cage activity (Sed) or 30 min per day of treadmill exercise (Ex) for 21 consecutive days. BAPN caused a downward shift in the D-spacing distribution in Sed BAPN compared with Sed PBS (Po0.001) but not in Ex BAPN (P ¼ 0.429), indicating that exercise can prevent changes in collagen morphology caused by BAPN. Exercise had no effect on D-spacing in PBS control mice (P ¼ 0.726), which suggests that exercise-induced increases in lysyl oxidase may be a possible mechanism for preventing BAPN-induced changes in D-spacing. The D-spacing changes were accompanied by an increase in mineral crystallinity/maturity due to the main effect of BAPN (P ¼ 0.016). However, no changes in nanoindentation, reference point indentation or other Raman spectroscopy parameters were observed. The ability of exercise to rescue BAPN-driven changes in collagen morphology necessitates further research into the use of mechanical stimulation as a preventative therapy for collagen-based diseases.

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Section: Introductionmentioning

confidence: 99%

Exercise prevents β-aminopropionitrile-induced morphological changes to type I collagen in murine bone

Hammond¹,

Wallace²

2015

BoneKEy Reports

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“…sativus, which contains L-BOAA and BAPN. Neurolathyrism, osteolathyrism and angiolathyrism have been reported after intake of large amounts of L. sativus in Bangladesh (Haque et al, 1997).…”

Section: Accepted Manuscript 21mentioning

confidence: 99%

Are wild and cultivated flowers served in restaurants or sold by local producers in Denmark safe for the consumer?

Pedersen

Olesen

Eriksen

et al. 2018

Food and Chemical Toxicology

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New Nordic Food has within the last decade received much media coverage with chefs of top restaurants using wild plants for foods. As part of a control campaign, the Danish Veterinary and Food Administration visited 150 restaurants and local food producers from May-October 2016 and investigated their use of plants picked from the wild, cultivated in private gardens or market gardens. Among the species used were the flowers from 23 plants. Here we present a safety evaluation of these flowers based on published phytochemical investigations and toxicological data in humans, farm animals, pets, or experimental animals. Of the 23 flowers reviewed, nine contained compounds with toxic or potentially toxic effects if eaten, two contained unidentified toxic compound(s), and four were flowers from plants with potentially toxic compounds present in other plant parts or related species. Many of the flowers may be considered novel, since a use to a significant degree in Europe prior to 15 May 1997 before Regulation (EC) 258/97 on novel food and novel food ingredients came into force could not be established. In conclusion, this review illuminates a striking lack of chemical and toxicological data of many of the proposed wild or cultivated flowers for food use.

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“…Even, although the grass pea production has increased in Bangladesh, no new cases of neurolathyrism have been reported. The price of grass pea is now equal or higher than that of rice and, hence, overconsumption as the cheapest food is no longer a risk for the poor (Haque et al 1997).…”

Section: Neurolathyrismmentioning

confidence: 99%

Grass pea (Lathyrus sativus L.): orphan crop, nutraceutical or just plain food?

Lambein

Travella

Kuo

et al. 2019

Planta

Self Cite

138

127

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Main conclusion Although grass pea is an environmentally successful robust legume with major traits of interest for food and nutrition security, the genetic potential of this orphan crop has long been neglected. Grass pea (Lathyrus sativus L.) is a Neolithic plant that has survived millennia of cultivation and has spread over three continents. It is a robust legume crop that is considered one of the most resilient to climate changes and to be survival food during drought-triggered famines. The hardy penetrating root system allows the cultivation of grass pea in various soil types, including marginal ones. As an efficient nitrogen fixer, it meets its own nitrogen requirements and positively benefits subsequent crops. However, already in ancient India and Greece, overconsumption of the seeds and a crippling neurological disorder, later coined neurolathyrism, had been linked. Overemphasis of their suspected toxic properties has led to disregard the plant's exceptionally positive agronomic properties and dietary advantages. In normal socioeconomic and environmental situations, in which grass pea is part of a balanced diet, neurolathyrism is virtually non-existent. The etiology of neurolathyrism has been oversimplified and the deficiency in methionine in the diet has been overlooked. In view of the global climate change, this very adaptable and nutritious orphan crop deserves more attention. Grass pea can become a wonder crop if the double stigma on its reputation as a toxic plant and as food of the poor can be disregarded. Additionally, recent research has exposed the potential of grass pea as a health-promoting nutraceutical. Development of varieties with an improved balance in essential amino acids and diet may be relevant to enhance the nutritional value without jeopardizing the multiple stress tolerance of this promising crop.

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Evidence of osteolathyrism among patients suffering from neurolathyrism in Bangladesh

Cited by 27 publications

References 16 publications

Exercise prevents β-aminopropionitrile-induced morphological changes to type I collagen in murine bone

Exercise prevents β-aminopropionitrile-induced morphological changes to type I collagen in murine bone

Are wild and cultivated flowers served in restaurants or sold by local producers in Denmark safe for the consumer?

Grass pea (Lathyrus sativus L.): orphan crop, nutraceutical or just plain food?

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